Genetic Association and Gene Expression Analysis Identify FGFR1 as a New Susceptibility Gene for Human Obesity

• Published in: The journal of clinical endocrinology and metabolism Vol. 96; no. 6; pp. E962 - E966
• Main Authors: Jiao, Hong, Arner, Peter, Dickson, Suzanne L, Vidal, Hubert, Mejhert, Niklas, Henegar, Corneliu, Taube, Magdalena, Hansson, Caroline, Hinney, Anke, Galan, Pilar, Simon, Chantal, Silveira, Angela, Benrick, Anna, Jansson, John-Olov, Bouloumié, Anne, Langin, Dominique, Laville, Martine, Debard, Cyrille, Axelsson, Tomas, Rydén, Mikael, Kere, Juha, Dahlman-Wright, Karin, Hamsten, Anders, Clement, Karine, Dahlman, Ingrid
• Format: Journal Article
• Language: English
• Published: United States Endocrine Society 01.06.2011
• Subjects: Adipose Tissue - metabolism; Adolescent; Adult; Animals; Appetite - genetics; Biochemistry, Molecular Biology; Blotting, Western; Chi-Square Distribution; Child; European Continental Ancestry Group; Female; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Haplotypes; Humans; Hypothalamus - metabolism; Life Sciences; Male; Medical Genetics; MEDICIN; Medicin och hälsovetenskap; MEDICINE; Medicinsk genetik; Muscle, Skeletal - metabolism; Obesity - genetics; Obesity - metabolism; Odds Ratio; Polymorphism, Single Nucleotide; Rats; Rats, Sprague-Dawley; Receptor, Fibroblast Growth Factor, Type 1 - genetics; Receptor, Fibroblast Growth Factor, Type 1 - metabolism; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - genetics; RNA, Messenger - metabolism; Haplotypes; RNA; Humans; Male; Hypothalamus; Blotting; Fibroblast Growth Factor; Skeletal; Single Nucleotide; Western; Sprague-Dawley; Adult; Female; Muscle; Adipose Tissue; Odds Ratio; Child; Type 1; Appetite; Obesity; Genetic Predisposition to Disease; Genetic Association Studies; Rats; European Continental Ancestry Group; Genotype; Messenger; Reverse Transcriptase Polymerase Chain Reaction; Chi-Square Distribution; Animals; Receptor; Adolescent; Polymorphism

FGFR1 is a novel susceptibility gene for obesity, which may promote obesity by influencing adipose tissue and the hypothalamic control of appetite. Context: Previous studies suggest a role for fibroblast growth factor receptor 1 (FGFR1) in the regulation of energy balance. Objective: Our objective w...