Deterioration of Phosphate Homeostasis Is a Trigger for Cardiac Afterload ― Clinical Importance of Fibroblast Growth Factor 23 for Accelerated Aging
Background: After the discovery of the Klotho gene, phosphate came into focus as a pathogenetic aging agent. Phosphate homeostasis is controlled by phosphate-regulating hormones: fibroblast growth factor 23 (FGF23), vitamin D3, and parathyroid hormone. This study investigated the relationship betwee...
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| Published in | Circulation Reports Vol. 5; no. 1; pp. 4 - 12 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
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Japan
The Japanese Circulation Society
10.01.2023
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| Subjects | |
| Online Access | Get full text |
| ISSN | 2434-0790 2434-0790 |
| DOI | 10.1253/circrep.CR-22-0124 |
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| Abstract | Background: After the discovery of the Klotho gene, phosphate came into focus as a pathogenetic aging agent. Phosphate homeostasis is controlled by phosphate-regulating hormones: fibroblast growth factor 23 (FGF23), vitamin D3, and parathyroid hormone. This study investigated the relationship between the deterioration in phosphate homeostasis and arterial stiffness by measuring serum FGF23 concentrations.Methods and Results: The study subjects comprised 82 hospitalized patients (31 males, 51 females; mean [±SD] age 78.6±10.5 years). All patients underwent chest computed tomography, measurement of central blood pressure (BP), and blood chemistry tests. Arterial calcification and/or stiffness was evaluated using the Agatston calcification score (ACS) and pulse wave velocity (PWV). PWV was significantly correlated with age (t=23.47, P<0.0001), estimated glomerular filtration rate (eGFR; t=−4.40, P<0.0001), and ACS (t=4.36, P<0.0001). Serum FGF23 concentrations were significantly correlated with age (t=2.52, P=0.014), eGFR (t=−3.37, P<0.001), serum inorganic phosphorus concentrations (t=3.49, P<0.001), serum vitamin D3concentrations (t=−4.57, P<0.001), ACS (t=2.30, P=0.025), augmentation pressure (t=2.48, P=0.015), central systolic BP (t=2.00, P=0.049), plasma B-type natriuretic peptide (BNP) concentrations (t=3.48, P<0.001), and PWV (t=2.99, P=0.004). PWV was positively related to augmentation pressure (t=4.09, P<0.001), central systolic BP (t=3.13, P=0.002), and plasma BNP concentrations (t=3.54, P<0.001).Conclusions: This study shows that the increase in serum FGF23 concentrations reflects deterioration of phosphate homeostasis and is an important predictor for arterial stiffness, which intensifies cardiac afterload. |
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| AbstractList | Background: After the discovery of the Klotho gene, phosphate came into focus as a pathogenetic aging agent. Phosphate homeostasis is controlled by phosphate-regulating hormones: fibroblast growth factor 23 (FGF23), vitamin D3, and parathyroid hormone. This study investigated the relationship between the deterioration in phosphate homeostasis and arterial stiffness by measuring serum FGF23 concentrations. Methods and Results: The study subjects comprised 82 hospitalized patients (31 males, 51 females; mean [±SD] age 78.6±10.5 years). All patients underwent chest computed tomography, measurement of central blood pressure (BP), and blood chemistry tests. Arterial calcification and/or stiffness was evaluated using the Agatston calcification score (ACS) and pulse wave velocity (PWV). PWV was significantly correlated with age (t=23.47, P<0.0001), estimated glomerular filtration rate (eGFR; t=-4.40, P<0.0001), and ACS (t=4.36, P<0.0001). Serum FGF23 concentrations were significantly correlated with age (t=2.52, P=0.014), eGFR (t=-3.37, P<0.001), serum inorganic phosphorus concentrations (t=3.49, P<0.001), serum vitamin D3 concentrations (t=-4.57, P<0.001), ACS (t=2.30, P=0.025), augmentation pressure (t=2.48, P=0.015), central systolic BP (t=2.00, P=0.049), plasma B-type natriuretic peptide (BNP) concentrations (t=3.48, P<0.001), and PWV (t=2.99, P=0.004). PWV was positively related to augmentation pressure (t=4.09, P<0.001), central systolic BP (t=3.13, P=0.002), and plasma BNP concentrations (t=3.54, P<0.001). Conclusions: This study shows that the increase in serum FGF23 concentrations reflects deterioration of phosphate homeostasis and is an important predictor for arterial stiffness, which intensifies cardiac afterload.Background: After the discovery of the Klotho gene, phosphate came into focus as a pathogenetic aging agent. Phosphate homeostasis is controlled by phosphate-regulating hormones: fibroblast growth factor 23 (FGF23), vitamin D3, and parathyroid hormone. This study investigated the relationship between the deterioration in phosphate homeostasis and arterial stiffness by measuring serum FGF23 concentrations. Methods and Results: The study subjects comprised 82 hospitalized patients (31 males, 51 females; mean [±SD] age 78.6±10.5 years). All patients underwent chest computed tomography, measurement of central blood pressure (BP), and blood chemistry tests. Arterial calcification and/or stiffness was evaluated using the Agatston calcification score (ACS) and pulse wave velocity (PWV). PWV was significantly correlated with age (t=23.47, P<0.0001), estimated glomerular filtration rate (eGFR; t=-4.40, P<0.0001), and ACS (t=4.36, P<0.0001). Serum FGF23 concentrations were significantly correlated with age (t=2.52, P=0.014), eGFR (t=-3.37, P<0.001), serum inorganic phosphorus concentrations (t=3.49, P<0.001), serum vitamin D3 concentrations (t=-4.57, P<0.001), ACS (t=2.30, P=0.025), augmentation pressure (t=2.48, P=0.015), central systolic BP (t=2.00, P=0.049), plasma B-type natriuretic peptide (BNP) concentrations (t=3.48, P<0.001), and PWV (t=2.99, P=0.004). PWV was positively related to augmentation pressure (t=4.09, P<0.001), central systolic BP (t=3.13, P=0.002), and plasma BNP concentrations (t=3.54, P<0.001). Conclusions: This study shows that the increase in serum FGF23 concentrations reflects deterioration of phosphate homeostasis and is an important predictor for arterial stiffness, which intensifies cardiac afterload. After the discovery of the Klotho gene, phosphate came into focus as a pathogenetic aging agent. Phosphate homeostasis is controlled by phosphate-regulating hormones: fibroblast growth factor 23 (FGF23), vitamin D , and parathyroid hormone. This study investigated the relationship between the deterioration in phosphate homeostasis and arterial stiffness by measuring serum FGF23 concentrations. The study subjects comprised 82 hospitalized patients (31 males, 51 females; mean [±SD] age 78.6±10.5 years). All patients underwent chest computed tomography, measurement of central blood pressure (BP), and blood chemistry tests. Arterial calcification and/or stiffness was evaluated using the Agatston calcification score (ACS) and pulse wave velocity (PWV). PWV was significantly correlated with age (t=23.47, P<0.0001), estimated glomerular filtration rate (eGFR; t=-4.40, P<0.0001), and ACS (t=4.36, P<0.0001). Serum FGF23 concentrations were significantly correlated with age (t=2.52, P=0.014), eGFR (t=-3.37, P<0.001), serum inorganic phosphorus concentrations (t=3.49, P<0.001), serum vitamin D concentrations (t=-4.57, P<0.001), ACS (t=2.30, P=0.025), augmentation pressure (t=2.48, P=0.015), central systolic BP (t=2.00, P=0.049), plasma B-type natriuretic peptide (BNP) concentrations (t=3.48, P<0.001), and PWV (t=2.99, P=0.004). PWV was positively related to augmentation pressure (t=4.09, P<0.001), central systolic BP (t=3.13, P=0.002), and plasma BNP concentrations (t=3.54, P<0.001). This study shows that the increase in serum FGF23 concentrations reflects deterioration of phosphate homeostasis and is an important predictor for arterial stiffness, which intensifies cardiac afterload. Background: After the discovery of the Klotho gene, phosphate came into focus as a pathogenetic aging agent. Phosphate homeostasis is controlled by phosphate-regulating hormones: fibroblast growth factor 23 (FGF23), vitamin D3, and parathyroid hormone. This study investigated the relationship between the deterioration in phosphate homeostasis and arterial stiffness by measuring serum FGF23 concentrations.Methods and Results: The study subjects comprised 82 hospitalized patients (31 males, 51 females; mean [±SD] age 78.6±10.5 years). All patients underwent chest computed tomography, measurement of central blood pressure (BP), and blood chemistry tests. Arterial calcification and/or stiffness was evaluated using the Agatston calcification score (ACS) and pulse wave velocity (PWV). PWV was significantly correlated with age (t=23.47, P<0.0001), estimated glomerular filtration rate (eGFR; t=−4.40, P<0.0001), and ACS (t=4.36, P<0.0001). Serum FGF23 concentrations were significantly correlated with age (t=2.52, P=0.014), eGFR (t=−3.37, P<0.001), serum inorganic phosphorus concentrations (t=3.49, P<0.001), serum vitamin D3concentrations (t=−4.57, P<0.001), ACS (t=2.30, P=0.025), augmentation pressure (t=2.48, P=0.015), central systolic BP (t=2.00, P=0.049), plasma B-type natriuretic peptide (BNP) concentrations (t=3.48, P<0.001), and PWV (t=2.99, P=0.004). PWV was positively related to augmentation pressure (t=4.09, P<0.001), central systolic BP (t=3.13, P=0.002), and plasma BNP concentrations (t=3.54, P<0.001).Conclusions: This study shows that the increase in serum FGF23 concentrations reflects deterioration of phosphate homeostasis and is an important predictor for arterial stiffness, which intensifies cardiac afterload. |
| ArticleNumber | CR-22-0124 |
| Author | Kugimiya, Fumihito Nakayama, Yoshiharu Ishida, Toshifumi Yonemitsu, Koichiro Harada, Eisaku Mizuno, Yuji Takai, Seiko |
| Author_xml | – sequence: 1 fullname: Yonemitsu, Koichiro organization: Division of Emergency Room, Kumamoto Kinoh Hospital – sequence: 1 fullname: Ishida, Toshifumi organization: Department of Cardiovascular Medicine, Faculty of Life Science, Graduate School of Medical Sciences, Kumamoto University – sequence: 1 fullname: Takai, Seiko organization: Division of Orthopedics, Kumamoto Kinoh Hospital – sequence: 1 fullname: Harada, Eisaku organization: Division of Cardiovascular Medicine, Kumamoto Kinoh Hospital – sequence: 1 fullname: Kugimiya, Fumihito organization: Division of Cardiovascular Medicine, Kumamoto Kinoh Hospital – sequence: 1 fullname: Mizuno, Yuji organization: Division of Cardiovascular Medicine, Mizuno Heart Clinic – sequence: 1 fullname: Nakayama, Yoshiharu organization: Division of Radiology Imaging, Kumamoto Kinoh Hospital |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/36643091$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1038/ki.2012.327 10.1177/000456329703400606 10.1097/MBP.0b013e328339be38 10.1253/circj.CJ-14-0735 10.1007/s11154-011-9199-8 10.1038/srep24879 10.1097/HJH.0b013e3282f62a9b 10.1038/s41598-020-77308-3 10.1161/CIRCULATIONAHA.107.706127 10.1124/jpet.117.247270 10.1097/MBP.0b013e328338892f 10.1172/JCI15219 10.1359/jbmr.2001.16.4.605 10.1097/HJH.0000000000001406 10.1016/j.mad.2010.02.008 10.18632/aging.102297 10.3390/nu10050652 10.1146/annurev.med.051308.111339 10.1253/circj.CJ-08-0308 10.1016/j.jacbts.2020.02.002 10.4103/jcecho.jcecho_82_17 10.1016/j.acra.2007.05.021 10.1161/01.ATV.0000160548.78317.29 10.5551/jat.RV17045 10.1016/j.kint.2019.10.019 10.1007/s00424-018-2231-z 10.1161/hy1201.098767 10.1097/QAD.0000000000002414 10.1161/CIRCULATIONAHA.113.002654 10.1038/36285 10.1210/jc.2002-021105 10.1161/01.ATV.0000133194.94939.42 |
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| Keywords | Calcification Arterial stiffness Fibroblast growth factor 23 Phosphate Afterload |
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| References | 32. Wang J, Zhou JJ, Robertson GR, Lee VW. Vitamin D in vascular calcification: A double-edged sword? Nutrients 2018; 10: 652, doi:10.3390/nu10050652. 5. Gross P, Six I, Kamel S, Massy ZA. Vascular toxicity of phosphate in chronic kidney disease: Beyond vascular calcification. Circ J 2014; 78: 2339–2346, doi:10.1253/circj.cj-14-0735. 23. Pruijm M, Lu Y, Megdiche F, Piskunowicz M, Milani B, Stuber M, et al. Serum calcification propensity is associated with renal tissue oxygenation and resistive index in patients with arterial hypertension or chronic kidney disease. J Hypertens 2017; 35: 2044–2052, doi:10.1097/hjh.0000000000001406. 10. Kassi E, Adamopoulos C, Basdra EK, Papavassiliou AG. Role of vitamin D in atherosclerosis. Circulation 2013; 128: 2517–2531, doi:10.1161/circulationaha.113.002654. 24. Brew BJ, McArthur JC. ‘A man is as old as his arteries’ (attributed to Thomas Sydenham, the English Hippocrates). Aids 2020; 34: 637–639, doi:10.1097/qad.0000000000002414. 26. Zieman SJ, Melenovsky V, Kass DA. Mechanisms, pathophysiology, and therapy of arterial stiffness. Arterioscler Thromb Vasc Biol 2005; 25: 932–943, doi:10.1161/01.Atv.0000160548.78317.29. 17. Gao P, Scheibel S, D’Amour P, John MR, Rao SD, Schmidt-Gayk H, et al. Development of a novel immunoradiometric assay exclusively for biologically active whole parathyroid hormone 1–84: Implications for improvement of accurate assessment of parathyroid function. J Bone Miner Res 2001; 16: 605–614, doi:10.1359/jbmr.2001.16.4.605. 30. McCabe KM, Zelt JG, Kaufmann M, Laverty K, Ward E, Barron H, et al. Calcitriol accelerates vascular calcification irrespective of vitamin K status in a rat model of chronic kidney disease with hyperphosphatemia and secondary hyperparathyroidism. J Pharmacol Exp Ther 2018; 366: 433–445, doi:10.1124/jpet.117.247270. 6. Haussler MR, Whitfield GK, Kaneko I, Forster R, Saini R, Hsieh JC, et al. The role of vitamin D in the FGF23, klotho, and phosphate bone-kidney endocrine axis. Rev Endocr Metab Disord 2012; 13: 57–69, doi:10.1007/s11154-011-9199-8. 7. Ärnlöv J, Carlsson AC, Sundström J, Ingelsson E, Larsson A, Lind L, et al. Higher fibroblast growth factor-23 increases the risk of all-cause and cardiovascular mortality in the community. Kidney Int 2013; 83: 160–166, doi:10.1038/ki.2012.327. 25. Donate-Correa J, Martín-Núñez E, Hernández-Carballo C, Ferri C, Tagua VG, Delgado-Molinos A, et al. Fibroblast growth factor 23 expression in human calcified vascular tissues. Aging (Albany NY) 2019; 11: 7899–7913, doi:10.18632/aging.102297. 27. Fujiu A, Ogawa T, Matsuda N, Ando Y, Nitta K. Aortic arch calcification and arterial stiffness are independent factors for diastolic left ventricular dysfunction in chronic hemodialysis patients. Circ J 2008; 72: 1768–1772, doi:10.1253/circj.cj-08-0308. 11. Wang TJ, Pencina MJ, Booth SL, Jacques PF, Ingelsson E, Lanier K, et al. Vitamin D deficiency and risk of cardiovascular disease. Circulation 2008; 117: 503–511, doi:10.1161/circulationaha.107.706127. 2. Nelson AJ, Raggi P, Wolf M, Gold AM, Chertow GM, Roe MT. Targeting vascular calcification in chronic kidney disease. JACC Basic Transl Sci 2020; 5: 398–412, doi:10.1016/j.jacbts.2020.02.002. 4. Kuro OM. Phosphate as a pathogen of arteriosclerosis and aging. J Atheroscler Thromb 2021; 28: 203–213, doi:10.5551/jat.RV17045. 22. Hashimoto J, Westerhof BE, Westerhof N, Imai Y, O’Rourke MF. Different role of wave reflection magnitude and timing on left ventricular mass reduction during antihypertensive treatment. J Hypertens 2008; 26: 1017–1024, doi:10.1097/HJH.0b013e3282f62a9b. 16. Fraser WD, Durham BH, Berry JL, Mawer EB. Measurement of plasma 1,25 dihydroxyvitamin D using a novel immunoextraction technique and immunoassay with iodine labelled vitamin D tracer. Ann Clin Biochem 1997; 34: 632–637, doi:10.1177/000456329703400606. 9. Jacquillet G, Unwin RJ. Physiological regulation of phosphate by vitamin D, parathyroid hormone (PTH) and phosphate (Pi). Pflügers Arch 2019; 471: 83–98, doi:10.1007/s00424-018-2231-z. 21. Vlachopoulos C, Hirata K, O’Rourke MF. Pressure-altering agents affect central aortic pressures more than is apparent from upper limb measurements in hypertensive patients: The role of arterial wave reflections. Hypertension 2001; 38: 1456–1460, doi:10.1161/hy1201.098767. 28. Li YC, Kong J, Wei M, Chen ZF, Liu SQ, Cao LP. 1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system. J Clin Invest 2002; 110: 229–238, doi:10.1172/jci15219. 1. Kuro-o M. A potential link between phosphate and aging: Lessons from Klotho-deficient mice. Mech Ageing Dev 2010; 131: 270–275, doi:10.1016/j.mad.2010.02.008. 18. Abedin M, Tintut Y, Demer LL. Vascular calcification: Mechanisms and clinical ramifications. Arterioscler Thromb Vasc Biol 2004; 24: 1161–1170, doi:10.1161/01.Atv.0000133194.94939.42. 14. Budoff MJ, Katz R, Wong ND, Nasir K, Mao SS, Takasu J, et al. Effect of scanner type on the reproducibility of extracoronary measures of calcification: The multi-ethnic study of atherosclerosis. Acad Radiol 2007; 14: 1043–1049, doi:10.1016/j.acra.2007.05.021. 20. Kunishige R, Mizoguchi M, Tsubouchi A, Hanaoka K, Miura Y, Kurosu H, et al. Calciprotein particle-induced cytotoxicity via lysosomal dysfunction and altered cholesterol distribution in renal epithelial HK-2 cells. Sci Rep 2020; 10: 20125, doi:10.1038/s41598-020-77308-3. 31. Leibrock CB, Voelkl J, Kuro OM, Lang F, Lang UE. 1,25(OH)2D3 dependent overt hyperactivity phenotype in klotho-hypomorphic mice. Sci Rep 2016; 6: 24879, doi:10.1038/srep24879. 19. Akiyama KI, Miura Y, Hayashi H, Sakata A, Matsumura Y, Kojima M, et al. Calciprotein particles regulate fibroblast growth factor-23 expression in osteoblasts. Kidney Int 2020; 97: 702–712, doi:10.1016/j.kint.2019.10.019. 12. Wei W, Tölle M, Zidek W, van der Giet M. Validation of the mobil-O-Graph: 24 h-blood pressure measurement device. Blood Press Monit 2010; 15: 225–228, doi:10.1097/MBP.0b013e328338892f. 3. Kuro-o M, Matsumura Y, Aizawa H, Kawaguchi H, Suga T, Utsugi T, et al. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 1997; 390: 45–51, doi:10.1038/36285. 29. Hacioglu Y, Karabag T, Piskinpasa ME, Sametoglu F, Yuksel Y. Impaired cardiac functions and aortic elastic properties in patients with severe vitamin D deficiency. J Cardiovasc Echogr 2018; 28: 171–176, doi:10.4103/jcecho.jcecho_82_17. 8. Bergwitz C, Jüppner H. Regulation of phosphate homeostasis by PTH, vitamin D, and FGF23. Annu Rev Med 2010; 61: 91–104, doi:10.1146/annurev.med.051308.111339. 13. Franssen PM, Imholz BP. Evaluation of the Mobil-O-Graph new generation ABPM device using the ESH criteria. Blood Press Monit 2010; 15: 229–231, doi:10.1097/mbp.0b013e328339be38. 15. Yamazaki Y, Okazaki R, Shibata M, Hasegawa Y, Satoh K, Tajima T, et al. Increased circulatory level of biologically active full-length FGF-23 in patients with hypophosphatemic rickets/osteomalacia. J Clin Endocrinol Metab 2002; 87: 4957–4960, doi:10.1210/jc.2002-021105. 22 23 24 25 26 27 28 29 30 31 10 32 11 12 13 14 15 16 17 18 19 1 2 3 4 5 6 7 8 9 20 21 36909134 - Circ Rep. 2023 Mar 10;5(3):103-104 |
| References_xml | – reference: 20. Kunishige R, Mizoguchi M, Tsubouchi A, Hanaoka K, Miura Y, Kurosu H, et al. Calciprotein particle-induced cytotoxicity via lysosomal dysfunction and altered cholesterol distribution in renal epithelial HK-2 cells. Sci Rep 2020; 10: 20125, doi:10.1038/s41598-020-77308-3. – reference: 28. Li YC, Kong J, Wei M, Chen ZF, Liu SQ, Cao LP. 1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system. J Clin Invest 2002; 110: 229–238, doi:10.1172/jci15219. – reference: 2. Nelson AJ, Raggi P, Wolf M, Gold AM, Chertow GM, Roe MT. Targeting vascular calcification in chronic kidney disease. JACC Basic Transl Sci 2020; 5: 398–412, doi:10.1016/j.jacbts.2020.02.002. – reference: 7. Ärnlöv J, Carlsson AC, Sundström J, Ingelsson E, Larsson A, Lind L, et al. Higher fibroblast growth factor-23 increases the risk of all-cause and cardiovascular mortality in the community. Kidney Int 2013; 83: 160–166, doi:10.1038/ki.2012.327. – reference: 9. Jacquillet G, Unwin RJ. Physiological regulation of phosphate by vitamin D, parathyroid hormone (PTH) and phosphate (Pi). Pflügers Arch 2019; 471: 83–98, doi:10.1007/s00424-018-2231-z. – reference: 10. Kassi E, Adamopoulos C, Basdra EK, Papavassiliou AG. Role of vitamin D in atherosclerosis. Circulation 2013; 128: 2517–2531, doi:10.1161/circulationaha.113.002654. – reference: 27. Fujiu A, Ogawa T, Matsuda N, Ando Y, Nitta K. Aortic arch calcification and arterial stiffness are independent factors for diastolic left ventricular dysfunction in chronic hemodialysis patients. Circ J 2008; 72: 1768–1772, doi:10.1253/circj.cj-08-0308. – reference: 15. Yamazaki Y, Okazaki R, Shibata M, Hasegawa Y, Satoh K, Tajima T, et al. Increased circulatory level of biologically active full-length FGF-23 in patients with hypophosphatemic rickets/osteomalacia. J Clin Endocrinol Metab 2002; 87: 4957–4960, doi:10.1210/jc.2002-021105. – reference: 4. Kuro OM. Phosphate as a pathogen of arteriosclerosis and aging. J Atheroscler Thromb 2021; 28: 203–213, doi:10.5551/jat.RV17045. – reference: 5. Gross P, Six I, Kamel S, Massy ZA. Vascular toxicity of phosphate in chronic kidney disease: Beyond vascular calcification. Circ J 2014; 78: 2339–2346, doi:10.1253/circj.cj-14-0735. – reference: 23. Pruijm M, Lu Y, Megdiche F, Piskunowicz M, Milani B, Stuber M, et al. Serum calcification propensity is associated with renal tissue oxygenation and resistive index in patients with arterial hypertension or chronic kidney disease. J Hypertens 2017; 35: 2044–2052, doi:10.1097/hjh.0000000000001406. – reference: 17. Gao P, Scheibel S, D’Amour P, John MR, Rao SD, Schmidt-Gayk H, et al. Development of a novel immunoradiometric assay exclusively for biologically active whole parathyroid hormone 1–84: Implications for improvement of accurate assessment of parathyroid function. J Bone Miner Res 2001; 16: 605–614, doi:10.1359/jbmr.2001.16.4.605. – reference: 31. Leibrock CB, Voelkl J, Kuro OM, Lang F, Lang UE. 1,25(OH)2D3 dependent overt hyperactivity phenotype in klotho-hypomorphic mice. Sci Rep 2016; 6: 24879, doi:10.1038/srep24879. – reference: 1. Kuro-o M. A potential link between phosphate and aging: Lessons from Klotho-deficient mice. Mech Ageing Dev 2010; 131: 270–275, doi:10.1016/j.mad.2010.02.008. – reference: 22. Hashimoto J, Westerhof BE, Westerhof N, Imai Y, O’Rourke MF. Different role of wave reflection magnitude and timing on left ventricular mass reduction during antihypertensive treatment. J Hypertens 2008; 26: 1017–1024, doi:10.1097/HJH.0b013e3282f62a9b. – reference: 30. McCabe KM, Zelt JG, Kaufmann M, Laverty K, Ward E, Barron H, et al. Calcitriol accelerates vascular calcification irrespective of vitamin K status in a rat model of chronic kidney disease with hyperphosphatemia and secondary hyperparathyroidism. J Pharmacol Exp Ther 2018; 366: 433–445, doi:10.1124/jpet.117.247270. – reference: 14. Budoff MJ, Katz R, Wong ND, Nasir K, Mao SS, Takasu J, et al. Effect of scanner type on the reproducibility of extracoronary measures of calcification: The multi-ethnic study of atherosclerosis. Acad Radiol 2007; 14: 1043–1049, doi:10.1016/j.acra.2007.05.021. – reference: 3. Kuro-o M, Matsumura Y, Aizawa H, Kawaguchi H, Suga T, Utsugi T, et al. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 1997; 390: 45–51, doi:10.1038/36285. – reference: 16. Fraser WD, Durham BH, Berry JL, Mawer EB. Measurement of plasma 1,25 dihydroxyvitamin D using a novel immunoextraction technique and immunoassay with iodine labelled vitamin D tracer. Ann Clin Biochem 1997; 34: 632–637, doi:10.1177/000456329703400606. – reference: 18. Abedin M, Tintut Y, Demer LL. Vascular calcification: Mechanisms and clinical ramifications. Arterioscler Thromb Vasc Biol 2004; 24: 1161–1170, doi:10.1161/01.Atv.0000133194.94939.42. – reference: 12. Wei W, Tölle M, Zidek W, van der Giet M. Validation of the mobil-O-Graph: 24 h-blood pressure measurement device. Blood Press Monit 2010; 15: 225–228, doi:10.1097/MBP.0b013e328338892f. – reference: 26. Zieman SJ, Melenovsky V, Kass DA. Mechanisms, pathophysiology, and therapy of arterial stiffness. Arterioscler Thromb Vasc Biol 2005; 25: 932–943, doi:10.1161/01.Atv.0000160548.78317.29. – reference: 32. Wang J, Zhou JJ, Robertson GR, Lee VW. Vitamin D in vascular calcification: A double-edged sword? Nutrients 2018; 10: 652, doi:10.3390/nu10050652. – reference: 6. Haussler MR, Whitfield GK, Kaneko I, Forster R, Saini R, Hsieh JC, et al. The role of vitamin D in the FGF23, klotho, and phosphate bone-kidney endocrine axis. Rev Endocr Metab Disord 2012; 13: 57–69, doi:10.1007/s11154-011-9199-8. – reference: 13. Franssen PM, Imholz BP. Evaluation of the Mobil-O-Graph new generation ABPM device using the ESH criteria. Blood Press Monit 2010; 15: 229–231, doi:10.1097/mbp.0b013e328339be38. – reference: 8. Bergwitz C, Jüppner H. Regulation of phosphate homeostasis by PTH, vitamin D, and FGF23. Annu Rev Med 2010; 61: 91–104, doi:10.1146/annurev.med.051308.111339. – reference: 11. Wang TJ, Pencina MJ, Booth SL, Jacques PF, Ingelsson E, Lanier K, et al. Vitamin D deficiency and risk of cardiovascular disease. Circulation 2008; 117: 503–511, doi:10.1161/circulationaha.107.706127. – reference: 21. Vlachopoulos C, Hirata K, O’Rourke MF. Pressure-altering agents affect central aortic pressures more than is apparent from upper limb measurements in hypertensive patients: The role of arterial wave reflections. Hypertension 2001; 38: 1456–1460, doi:10.1161/hy1201.098767. – reference: 24. Brew BJ, McArthur JC. ‘A man is as old as his arteries’ (attributed to Thomas Sydenham, the English Hippocrates). Aids 2020; 34: 637–639, doi:10.1097/qad.0000000000002414. – reference: 19. Akiyama KI, Miura Y, Hayashi H, Sakata A, Matsumura Y, Kojima M, et al. Calciprotein particles regulate fibroblast growth factor-23 expression in osteoblasts. Kidney Int 2020; 97: 702–712, doi:10.1016/j.kint.2019.10.019. – reference: 29. Hacioglu Y, Karabag T, Piskinpasa ME, Sametoglu F, Yuksel Y. Impaired cardiac functions and aortic elastic properties in patients with severe vitamin D deficiency. J Cardiovasc Echogr 2018; 28: 171–176, doi:10.4103/jcecho.jcecho_82_17. – reference: 25. Donate-Correa J, Martín-Núñez E, Hernández-Carballo C, Ferri C, Tagua VG, Delgado-Molinos A, et al. Fibroblast growth factor 23 expression in human calcified vascular tissues. Aging (Albany NY) 2019; 11: 7899–7913, doi:10.18632/aging.102297. – ident: 7 doi: 10.1038/ki.2012.327 – ident: 16 doi: 10.1177/000456329703400606 – ident: 13 doi: 10.1097/MBP.0b013e328339be38 – ident: 5 doi: 10.1253/circj.CJ-14-0735 – ident: 6 doi: 10.1007/s11154-011-9199-8 – ident: 31 doi: 10.1038/srep24879 – ident: 22 doi: 10.1097/HJH.0b013e3282f62a9b – ident: 20 doi: 10.1038/s41598-020-77308-3 – ident: 11 doi: 10.1161/CIRCULATIONAHA.107.706127 – ident: 30 doi: 10.1124/jpet.117.247270 – ident: 12 doi: 10.1097/MBP.0b013e328338892f – ident: 28 doi: 10.1172/JCI15219 – ident: 17 doi: 10.1359/jbmr.2001.16.4.605 – ident: 23 doi: 10.1097/HJH.0000000000001406 – ident: 1 doi: 10.1016/j.mad.2010.02.008 – ident: 25 doi: 10.18632/aging.102297 – ident: 32 doi: 10.3390/nu10050652 – ident: 8 doi: 10.1146/annurev.med.051308.111339 – ident: 27 doi: 10.1253/circj.CJ-08-0308 – ident: 2 doi: 10.1016/j.jacbts.2020.02.002 – ident: 29 doi: 10.4103/jcecho.jcecho_82_17 – ident: 14 doi: 10.1016/j.acra.2007.05.021 – ident: 26 doi: 10.1161/01.ATV.0000160548.78317.29 – ident: 4 doi: 10.5551/jat.RV17045 – ident: 19 doi: 10.1016/j.kint.2019.10.019 – ident: 9 doi: 10.1007/s00424-018-2231-z – ident: 21 doi: 10.1161/hy1201.098767 – ident: 24 doi: 10.1097/QAD.0000000000002414 – ident: 10 doi: 10.1161/CIRCULATIONAHA.113.002654 – ident: 3 doi: 10.1038/36285 – ident: 15 doi: 10.1210/jc.2002-021105 – ident: 18 doi: 10.1161/01.ATV.0000133194.94939.42 – reference: 36909134 - Circ Rep. 2023 Mar 10;5(3):103-104 |
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| Snippet | Background: After the discovery of the Klotho gene, phosphate came into focus as a pathogenetic aging agent. Phosphate homeostasis is controlled by... After the discovery of the Klotho gene, phosphate came into focus as a pathogenetic aging agent. Phosphate homeostasis is controlled by phosphate-regulating... |
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| SubjectTerms | Afterload Arterial stiffness Calcification Fibroblast growth factor 23 Phosphate |
| Title | Deterioration of Phosphate Homeostasis Is a Trigger for Cardiac Afterload ― Clinical Importance of Fibroblast Growth Factor 23 for Accelerated Aging |
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