CD4+ T Cells Recognize Conserved Influenza A Epitopes through Shared Patterns of V-Gene Usage and Complementary Biochemical Features

• Published in: Cell reports (Cambridge) Vol. 32; no. 2; p. 107885
• Main Authors: Greenshields-Watson, Alexander, Attaf, Meriem, MacLachlan, Bruce J., Whalley, Thomas, Rius, Cristina, Wall, Aaron, Lloyd, Angharad, Hughes, Hywel, Strange, Kathryn E., Mason, Georgina H., Schauenburg, Andrea J., Hulin-Curtis, Sarah L., Geary, James, Chen, Yuan, Lauder, Sarah N., Smart, Kathryn, Vijaykrishna, Dhanasekaran, Grau, Miguel L., Shugay, Mikhail, Andrews, Robert, Dolton, Garry, Rizkallah, Pierre J., Gallimore, Awen M., Sewell, Andrew K., Godkin, Andrew J., Cole, David K.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 14.07.2020; Cell Press; Elsevier
• Subjects: Adult; Amino Acid Motifs; Amino Acid Sequence; Animals; biochemistry; Birds - virology; CD4 T cells; CD4-Positive T-Lymphocytes - immunology; clonotyping; Complementarity Determining Regions - chemistry; Conserved Sequence; Epitopes - chemistry; Epitopes - immunology; Female; Germ Cells - metabolism; HLA class II; HLA-DR1 Antigen - immunology; Humans; Immunodominant Epitopes - chemistry; Immunodominant Epitopes - immunology; Immunoglobulin Variable Region - genetics; immunology; influenza; Influenza A virus - immunology; Male; Middle Aged; peptide epitopes; Peptides - chemistry; Peptides - immunology; pHLA mutlimer; Receptors, Antigen, T-Cell - metabolism; Swine - virology; T cell receptor; Tissue Donors; Viral Proteins - immunology; X-ray crystallography; Young Adult; Zoonoses - immunology; Zoonoses - virology; influenza; X-ray crystallography; peptide epitopes; T cell receptor; clonotyping; pHLA mutlimer; biochemistry; HLA class II; CD4 T cells; immunology

T cell recognition of peptides presented by human leukocyte antigens (HLAs) is mediated by the highly variable T cell receptor (TCR). Despite this built-in TCR variability, individuals can mount immune responses against viral epitopes by using identical or highly related TCRs expressed on CD8+ T cel...