CD4+ T Cells Recognize Conserved Influenza A Epitopes through Shared Patterns of V-Gene Usage and Complementary Biochemical Features - Greenshields-Watson, Alexander; Attaf, Meriem; MacLachlan, Bruce J.; Whalley, Thomas; Rius, Cristina; Wall, Aaron; Lloyd, Angharad; Hughes, Hywel; Strange, Kathryn E.; Mason, Georgina H.; Schauenburg, Andrea J.; Hulin-Curtis, Sarah L.; et al. (Cell reports (Cambridge), 2020)
Keywords: Adult; Amino Acid Motifs; Amino Acid Sequence; Animals; biochemistry; Birds - virology; CD4 T cells; CD4-Positive T-Lymphocytes - immunology; clonotyping; Complementarity Determining Regions - chemistry; Conserved Sequence; Epitopes - chemistry; Epitopes - immunology; Female; Germ Cells - metabolism; HLA class II; HLA-DR1 Antigen - immunology; Humans; Immunodominant Epitopes - chemistry; Immunodominant Epitopes - immunology; Immunoglobulin Variable Region - genetics; immunology; influenza; Influenza A virus - immunology; Male; Middle Aged; peptide epitopes; Peptides - chemistry; Peptides - immunology; pHLA mutlimer; Receptors, Antigen, T-Cell - metabolism; Swine - virology; T cell receptor; Tissue Donors; Viral Proteins - immunology; X-ray crystallography; Young Adult; Zoonoses - immunology; Zoonoses - virology; influenza; X-ray crystallography; peptide epitopes; T cell receptor; clonotyping; pHLA mutlimer; biochemistry; HLA class II; CD4 T cells; immunology