Plasma Proteomics, The Human Proteome Project, and Cancer-Associated Alternative Splice Variant Proteins

• Published in: Biochimica et biophysica acta Vol. 1844; no. 5; pp. 866 - 873
• Main Author: Omenn, Gilbert S.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2014
• Subjects: alternative splicing; Alternative Splicing - genetics; antibodies; Biomarker; biomarkers; Biomarkers, Tumor - blood; Biomarkers, Tumor - genetics; Blood Proteins - classification; Blood Proteins - genetics; Blood Proteins - metabolism; Chromosomes, Human - genetics; Chromosomes, Human - metabolism; gene expression; genes; Human Genome Project; Human Plasma Peptide Atlas; Human Proteome Peptide Atlas; Human Proteome Project; Humans; mass spectrometry; neoplasms; Neoplasms - blood; Neoplasms - diagnosis; Neoplasms - genetics; pathogenesis; peptides; planning; Protein Isoforms; proteins; proteome; Proteome - analysis; proteomics; Proteomics - methods; Splice variant protein; Splice variant transcript; Biomarker; Human Proteome Project; Splice variant protein; Human Plasma Peptide Atlas; Human Proteome Peptide Atlas; Splice variant transcript
• ISSN: 1570-9639; 0006-3002; 1878-1454
• DOI: 10.1016/j.bbapap.2013.10.016

This article addresses three inter-related subjects: the development of the Human Plasma Proteome Peptide Atlas, the launch of the Human Proteome Project, and the emergence of alternative splice variant transcripts and proteins as important features of evolution and pathogenesis. The current Plasma...