Epithelial-Mesenchymal Plasticity in Cancer Progression and Metastasis

• Published in: Developmental cell Vol. 49; no. 3; pp. 361 - 374
• Main Authors: Lu, Wei, Kang, Yibin
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 06.05.2019
• Subjects: Animals; Cell Plasticity - physiology; Cell Transformation, Neoplastic - pathology; cellular plasticity; chemoresistance; Embryonic Development; Epithelial-Mesenchymal Transition - physiology; epithelial-to-mesenchymal transition; Fibroblasts - metabolism; Humans; immune evasion; metastasis; Neoplasm Invasiveness - pathology; Neoplasm Metastasis - pathology; Neoplasms - metabolism; Neoplasms - pathology; Neoplastic Stem Cells - pathology; Neovascularization, Pathologic - pathology; stemness; cellular plasticity; chemoresistance; immune evasion; metastasis; stemness; epithelial-to-mesenchymal transition

Epithelial-to-mesenchymal transition (EMT) and its reversed process, mesenchymal-to-epithelial transition (MET), are fundamental processes in embryonic development and tissue repair but confer malignant properties to carcinoma cells, including invasive behavior, cancer stem cell activity, and greate...