Evolution of ligands, receptors and metabolizing enzymes of thyroid signaling

• Published in: Molecular and cellular endocrinology Vol. 459; pp. 5 - 13
• Main Authors: Holzer, Guillaume, Roux, Natacha, Laudet, Vincent
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 25.12.2017; Elsevier
• Subjects: Animals; bioactive properties; Biological Evolution; Cellular Biology; Cnidaria; Cnidaria - anatomy & histology; Cnidaria - physiology; Echinodermata; emotions; enzymes; Evolution; frogs; Gene Expression Regulation, Developmental; Humans; Insecta - anatomy & histology; Insecta - physiology; insects; invertebrates; Iodide Peroxidase - genetics; Iodide Peroxidase - metabolism; Life Sciences; Ligands; metabolism; metamorphosis; Phylogeny; pleiotropy; Receptors, Thyroid Hormone - genetics; Receptors, Thyroid Hormone - metabolism; Signal Transduction - physiology; Species Specificity; tachycardia; Thyroid Gland - physiology; Thyroid hormone receptor; thyroid hormone receptors; thyroid hormones; Thyroxine - genetics; Thyroxine - metabolism; Triac; Triiodothyroacetic acid; Triiodothyronine; Triiodothyronine - analogs & derivatives; Triiodothyronine - genetics; Triiodothyronine - metabolism; Urochordata; Xenopus; Triac; Evolution; Triiodothyronine; Triiodothyroacetic acid; Thyroid hormone receptor; T3

Thyroid hormones (THs) play important roles in vertebrates such as the control of the metabolism, development and seasonality. Given the pleiotropic effects of thyroid disorders (developmental delay, mood disorder, tachycardia, etc), THs signaling is highly investigated, specially using mammalian mo...