Liver Cancer Cell of Origin, Molecular Class, and Effects on Patient Prognosis

• Published in: Gastroenterology (New York, N.Y. 1943) Vol. 152; no. 4; pp. 745 - 761
• Main Authors: Sia, Daniela, Villanueva, Augusto, Friedman, Scott L, Llovet, Josep M
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2017
• Subjects: Animals; Bile Duct Neoplasms - classification; Bile Duct Neoplasms - genetics; Bile Duct Neoplasms - metabolism; Bile Duct Neoplasms - pathology; Bile Ducts, Intrahepatic; Biomarkers, Tumor; Carcinogenesis - pathology; Carcinoma, Hepatocellular - classification; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - pathology; Cell Dedifferentiation; Cell Proliferation; Cell Transdifferentiation; Cholangiocarcinoma - classification; Cholangiocarcinoma - genetics; Cholangiocarcinoma - metabolism; Cholangiocarcinoma - pathology; Gastroenterology and Hepatology; Hepatocytes - pathology; Humans; Liver Cancer; Liver Neoplasms - classification; Liver Neoplasms - genetics; Liver Neoplasms - metabolism; Liver Neoplasms - pathology; Molecular Drivers; Prognosis; Stem Cells - pathology; Targeted Therapies; Tumor Escape; hepatitis B virus; mechanistic target of rapamycin; intrahepatic cholangiocarcinoma; hepatitis C virus; interleukin; HBV; hepatocellular carcinoma; mixed hepatocellular cholangiocarcinoma; PSC; IL; next-generation sequencing; HCC-CCA; iCCA; HCC; ▪; MTOR; TGF; cholangiolocellular carcinoma; fibrolamellar hepatocellular carcinoma; HCV; CLC; NGS; FLC; transforming growth factor; primary sclerosing cholangitis; Prognosis; Liver Cancer; Molecular Drivers; Targeted Therapies

Primary liver cancer is the second leading cause of cancer-related death worldwide and therefore a major public health challenge. We review hypotheses of the cell of origin of liver tumorigenesis and clarify the classes of liver cancer based on molecular features and how they affect patient prognosi...