Multiplatform Molecular Profiling Reveals Epigenomic Intratumor Heterogeneity in Ependymoma

Ependymomas exist within distinct genetic subgroups, but the molecular diversity within individual ependymomas is unknown. We perform multiplatform molecular profiling of 6 spatially distinct samples from an ependymoma with C11orf95-RELA fusion. DNA methylation and RNA sequencing distinguish cluster...

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Bibliographic Details
Published inCell reports (Cambridge) Vol. 30; no. 5; pp. 1300 - 1309.e5
Main Authors Liu, S. John, Magill, Stephen T., Vasudevan, Harish N., Hilz, Stephanie, Villanueva-Meyer, Javier E., Lastella, Sydney, Daggubati, Vikas, Spatz, Jordan, Choudhury, Abrar, Orr, Brent A., Demaree, Benjamin, Seo, Kyounghee, Ferris, Sean P., Abate, Adam R., Oberheim Bush, Nancy Ann, Bollen, Andrew W., McDermott, Michael W., Costello, Joseph F., Raleigh, David R.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 04.02.2020
Elsevier
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