Reactions of Peroxynitrite with Uric Acid: Formation of Reactive Intermediates, Alkylated Products and Triuret, and In Vivo Production of Triuret Under Conditions of Oxidative Stress

• Published in: Nucleosides, nucleotides & nucleic acids Vol. 28; no. 2; pp. 118 - 149
• Main Authors: Gersch, Christine, Palii, Sergiu P., Imaram, Witcha, Kim, Kyung Mee, Karumanchi, S. Ananth, Angerhofer, Alexander, Johnson, Richard J., Henderson, George N.
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis Group 01.02.2009
• Subjects: alkylation; Antioxidants - chemistry; Antioxidants - metabolism; ascorbate; cardiovascular disease; endothelial dysfunction; Female; Humans; hypertension; Hyperuricemia - blood; Hyperuricemia - metabolism; Hyperuricemia - urine; methyluric acid; Oxidants - metabolism; Oxidative Stress; peroxynitrite; Peroxynitrous Acid - chemistry; Peroxynitrous Acid - metabolism; Pre-Eclampsia - metabolism; Pre-Eclampsia - urine; preeclampsia; Pregnancy; reactive intermediates; triuret; Urea - analogs & derivatives; Urea - metabolism; Urea - urine; Uric acid; Uric Acid - chemistry; Uric Acid - metabolism
• ISSN: 1525-7770; 1532-2335; 1532-2335
• DOI: 10.1080/15257770902736400

Hyperuricemia is associated with hypertension, metabolic syndrome, preeclampsia, cardio-vascular disease and renal disease, all conditions associated with oxidative stress. We hypothesized that uric acid, a known antioxidant, might become prooxidative following its reaction with oxidants; and, there...