Hippocampal replay reflects specific past experiences rather than a plan for subsequent choice

• Published in: Neuron (Cambridge, Mass.) Vol. 109; no. 19; pp. 3149 - 3163.e6
• Main Authors: Gillespie, Anna K., Astudillo Maya, Daniela A., Denovellis, Eric L., Liu, Daniel F., Kastner, David B., Coulter, Michael E., Roumis, Demetris K., Eden, Uri T., Frank, Loren M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 06.10.2021
• Subjects: Algorithms; Animals; Choice Behavior - physiology; Conditioning, Operant; consolidation; decoding; Electrodes, Implanted; Goals; hippocampus; Hippocampus - physiology; learning; Linear Models; Male; Maze Learning; memory; Memory - physiology; navigation; planning; Rats; Rats, Long-Evans; replay; sharp wave ripples; Space Perception - physiology; planning; navigation; memory; hippocampus; sharp wave ripples; learning; replay; consolidation; decoding
• ISSN: 0896-6273; 1097-4199; 1097-4199
• DOI: 10.1016/j.neuron.2021.07.029

Executing memory-guided behavior requires storage of information about experience and later recall of that information to inform choices. Awake hippocampal replay, when hippocampal neural ensembles briefly reactivate a representation related to prior experience, has been proposed to critically contr...