Protein Tyrosine Phosphatase 1B Inhibition Protects against Podocyte Injury and Proteinuria
Protein tyrosine phosphatase 1B (PTP1B) is a ubiquitously expressed nonreceptor protein-tyrosine phosphatase that regulates various cellular functions, including migration. Recent studies suggest that an increased migratory phenotype of podocytes may be responsible for proteinuria and foot process e...
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Published in | The American journal of pathology Vol. 184; no. 8; pp. 2211 - 2224 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
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Elsevier Inc
01.08.2014
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Abstract | Protein tyrosine phosphatase 1B (PTP1B) is a ubiquitously expressed nonreceptor protein-tyrosine phosphatase that regulates various cellular functions, including migration. Recent studies suggest that an increased migratory phenotype of podocytes may be responsible for proteinuria and foot process effacement. The current study addresses the role of PTP1B in podocyte injury and proteinuria. PTP1B was markedly up-regulated in the glomerulus, notably in podocytes, in three rodent models of podocyte injury. Podocyte-specific ablation of the PTP1B gene ameliorated proteinuria induced by lipopolysaccharide and Adriamycin (doxorubicin). The use of a specific PTP1B inhibitor also protected against lipopolysaccharide-induced proteinuria. In contrast, podocyte-specific PTP1B transgenic male mice developed spontaneous proteinuria and foot process effacement. In cultured mouse podocytes, PTP1B knockdown and/or pretreatment with the PTP1B inhibitor blunted lipopolysaccharide-induced cell migration, activation of Src-family kinases (SFKs), and phosphorylation of focal adhesion kinase at Y397 (pFAKY397 ), the latter being crucial for cell migration. Lipopolysaccharide-injected mice showed increased glomerular expression of active SFKs and pFAKY397 , both of which were inhibited by podocyte-specific PTP1B knockout and the PTP1B inhibitor. Moreover, podocyte-specific PTP1B transgenic mice showed increased glomerular expression of active SFKs and pFAKY397 . In summary, PTP1B up-regulation in podocytes induces a migratory response by activating SFKs and FAK, leading to foot process effacement and proteinuria. Pharmacological inhibition of PTP1B may have therapeutic potential in the treatment of proteinuric diseases. |
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AbstractList | Protein tyrosine phosphatase 1B (PTP1B) is a ubiquitously expressed nonreceptor protein-tyrosine phosphatase that regulates various cellular functions, including migration. Recent studies suggest that an increased migratory phenotype of podocytes may be responsible for proteinuria and foot process effacement. The current study addresses the role of PTP1B in podocyte injury and proteinuria. PTP1B was markedly up-regulated in the glomerulus, notably in podocytes, in three rodent models of podocyte injury. Podocyte-specific ablation of the PTP1B gene ameliorated proteinuria induced by lipopolysaccharide and Adriamycin (doxorubicin). The use of a specific PTP1B inhibitor also protected against lipopolysaccharide-induced proteinuria. In contrast, podocyte-specific PTP1B transgenic male mice developed spontaneous proteinuria and foot process effacement. In cultured mouse podocytes, PTP1B knockdown and/or pretreatment with the PTP1B inhibitor blunted lipopolysaccharide-induced cell migration, activation of Src-family kinases (SFKs), and phosphorylation of focal adhesion kinase at Y397 (pFAK(Y397)), the latter being crucial for cell migration. Lipopolysaccharide-injected mice showed increased glomerular expression of active SFKs and pFAK(Y397), both of which were inhibited by podocyte-specific PTP1B knockout and the PTP1B inhibitor. Moreover, podocyte-specific PTP1B transgenic mice showed increased glomerular expression of active SFKs and pFAK(Y397). In summary, PTP1B up-regulation in podocytes induces a migratory response by activating SFKs and FAK, leading to foot process effacement and proteinuria. Pharmacological inhibition of PTP1B may have therapeutic potential in the treatment of proteinuric diseases. Protein tyrosine phosphatase 1B (PTP1B) is a ubiquitously expressed nonreceptor protein-tyrosine phosphatase that regulates various cellular functions, including migration. Recent studies suggest that an increased migratory phenotype of podocytes may be responsible for proteinuria and foot process effacement. The current study addresses the role of PTP1B in podocyte injury and proteinuria. PTP1B was markedly up-regulated in the glomerulus, notably in podocytes, in three rodent models of podocyte injury. Podocyte-specific ablation of the PTP1B gene ameliorated proteinuria induced by lipopolysaccharide and Adriamycin (doxorubicin). The use of a specific PTP1B inhibitor also protected against lipopolysaccharide-induced proteinuria. In contrast, podocyte-specific PTP1B transgenic male mice developed spontaneous proteinuria and foot process effacement. In cultured mouse podocytes, PTP1B knockdown and/or pretreatment with the PTP1B inhibitor blunted lipopolysaccharide-induced cell migration, activation of Src-family kinases (SFKs), and phosphorylation of focal adhesion kinase at Y397 (pFAKY397), the latter being crucial for cell migration. Lipopolysaccharide-injected mice showed increased glomerular expression of active SFKs and pFAKY397, both of which were inhibited by podocyte-specific PTP1B knockout and the PTP1B inhibitor. Moreover, podocyte-specific PTP1B transgenic mice showed increased glomerular expression of active SFKs and pFAKY397. In summary, PTP1B up-regulation in podocytes induces a migratory response by activating SFKs and FAK, leading to foot process effacement and proteinuria. Pharmacological inhibition of PTP1B may have therapeutic potential in the treatment of proteinuric diseases. |
Author | Baldwin, Cindy Aoudjit, Lamine Kumagai, Takanori Takano, Tomoko Robins, Richard Jiang, Ruihua Nezvitsky, Lisa |
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Cites_doi | 10.1152/ajprenal.90421.2008 10.1074/jbc.M100984200 10.1038/ki.2010.137 10.1074/jbc.271.49.31290 10.1016/0076-6879(88)62096-9 10.1111/j.1523-1755.2004.00964.x 10.1038/ki.2008.19 10.1126/science.283.5407.1544 10.1083/jcb.143.3.861 10.1038/nrm1549 10.1046/j.1523-1755.2000.00070.x 10.1681/ASN.2011010027 10.1128/MCB.00730-13 10.1016/S0021-9258(17)32113-0 10.1152/ajpendo.00274.2009 10.1074/jbc.M111.249060 10.1016/j.tibs.2010.03.004 10.1038/nm1696 10.1097/01.ASN.0000146689.88078.80 10.1016/j.bbrc.2006.08.053 10.1172/JCI27414 10.1016/j.tcb.2007.06.006 10.1128/MCB.00959-07 10.1093/emboj/18.9.2459 10.1016/j.ceb.2005.02.001 10.1172/JCI117531 10.1074/jbc.M502780200 10.1016/j.beem.2007.08.004 10.1038/nature04662 10.1038/sj.ki.5002691 10.1074/jbc.M101354200 10.1111/j.1742-4658.2008.06249.x 10.1111/j.1463-1326.2008.01022.x 10.1038/sj.ki.5002362 10.1038/sj.ki.5002291 10.1111/j.1742-4658.2008.06247.x 10.1128/MCB.18.1.250 10.1152/ajprenal.2000.279.4.F664 10.1016/S0960-9822(98)70066-1 10.1074/jbc.M301689200 10.1093/emboj/cdg067 10.2353/ajpath.2010.100263 10.2741/1114 10.1172/JCI7236 10.1038/nm1435 10.1046/j.1523-1755.2000.00034.x 10.1042/BJ20061548 10.1681/ASN.2010111196 10.1007/s10555-008-9115-1 10.1681/ASN.2009090991 10.1016/S1534-5807(02)00149-1 10.1155/2011/376543 10.1038/ng1963 10.1038/ki.2009.424 10.1159/000262317 10.1074/jbc.272.34.21113 10.1016/j.ghir.2007.06.003 10.1172/JCI20402 10.1016/B978-0-12-386041-5.00005-4 10.1016/0092-8674(93)90642-4 10.1074/jbc.R500030200 |
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References | Mundel, Reiser (bib2) 2010; 77 Jones, Blasutig, Eremina, Ruston, Bladt, Li, Huang, Larose, Li, Takano, Quaggin, Pawson (bib54) 2006; 440 Salant, Cybulsky (bib24) 1988; 162 Attias, Jiang, Aoudjit, Kawachi, Takano (bib20) 2010; 114 Delibegovic, Bence, Mody, Hong, Ko, Kim, Kahn, Neel (bib17) 2007; 27 Logar, Brinkkoetter, Krofft, Pippin, Shankland (bib52) 2007; 72 Stuible, Doody, Tremblay (bib65) 2008; 27 Hanks, Ryzhova, Shin, Brábek (bib32) 2003; 8 Alvira, Naughton, Bhatt, Tedesco, Landry, Cotter (bib23) 2011; 286 Erbe, Klaman, Wilson, Wan, Kirincich, Will, Xu, Kung, Wang, Tam, Lee, Tobin (bib15) 2009; 11 Arregui, Balsamo, Lilien (bib29) 1998; 143 Verma, Wharram, Kovari, Kunkel, Nihalani, Wary, Wiggins, Killen, Holzman (bib37) 2003; 278 Yu, Suleiman, Kim, Miner, Dani, Shaw, Akilesh (bib58) 2013; 33 Zhu, Sun, Aoudjit, Li, Kawachi, Lemay, Takano (bib19) 2008; 73 Waters, Wu, Huang, Liu, Holmyard, Onay, Jones, Egan, Robinson, Piscione (bib27) 2012; 23 Tiganis, Bennett (bib39) 2007; 402 Hall, Fu, Schaller (bib42) 2011; 288 Liu, Sells, Chernoff (bib50) 1998; 18 Elchebly, Payette, Michaliszyn, Cromlish, Collins, Loy, Normandin, Cheng, Himms-Hagen, Chan, Ramachandran, Gresser, Tremblay, Kennedy (bib10) 1999; 283 Fukada, Tonks (bib63) 2003; 22 Yip, Saha, Chernoff (bib14) 2010; 35 Li, Lemay, Aoudjit, Kawachi, Takano (bib26) 2004; 15 Brown, Cooper (bib36) 1996; 1287 Wang, St John, Kretzler, Wiggins, Abrahamson (bib7) 2000; 57 Morris, Rui (bib12) 2009; 297 Verma, Kovari, Soofi, Nihalani, Patrie, Holzman (bib38) 2006; 116 Bourdeau, Dubé, Tremblay (bib61) 2005; 17 Koren, Fantus (bib64) 2007; 21 Mitra, Hanson, Schlaepfer (bib41) 2005; 6 Whitelaw, Sutherland, Kearns, Morgan, Weaving, Garrick (bib59) 2001; 158 Nada, Yagi, Takeda, Tokunaga, Nakagawa, Ikawa, Okada, Aizawa (bib35) 1993; 73 Ma, Togawa, Soda, Zhang, Lee, Ma, Yu, Ardito, Czyzyk, Diggs, Joly, Hatakeyama, Kawahara, Holzman, Guan, Ishibe (bib4) 2010; 21 Liu, Sells, Chernoff (bib45) 1998; 8 Burridge, Sastry, Sallee (bib49) 2006; 281 Aoudjit, Jiang, Lee, New, Jones, Takano (bib16) 2011; 2011 Bridgewater, Dionne, Butt, Pin, Matsell (bib51) 2008; 18 Verhagen, Attia, Koomans, Joles (bib57) 2000; 279 Fukada, Tonks (bib62) 2001; 276 Burdisso, González, Arregui (bib47) 2013; 126 Uchida, Suzuki, Iwamoto, Kawachi, Ohno, Horita, Nitta (bib55) 2008; 73 Li, Zhu, Aoudjit, Latreille, Kawachi, Larose, Takano (bib53) 2006; 349 Bence, Delibegovic, Xue, Gorgun, Hotamisligil, Neel, Kahn (bib30) 2006; 12 Van Beneden, Geers, Pauwels, Mannaerts, Verbeelen, van Grunsven, Van den Branden (bib21) 2011; 22 Liu, Hill, Chernoff (bib44) 1996; 271 Kang, Li, Dai, Kiss, Wu, Liu (bib40) 2010; 78 van den Berg, van den Bergh Weerman, Assmann, Weening, Florquin (bib25) 2004; 66 Klinghoffer, Sachsenmaier, Cooper, Soriano (bib33) 1999; 18 Somani, Bignon, Mills, Siminovitch, Branch (bib48) 1997; 272 Reiser, von Gersdorff, Loos, Oh, Asanuma, Giardino, Rastaldi, Calvaresi, Watanabe, Schwarz, Faul, Kretzler, Davidson, Sugimoto, Kalluri, Sharpe, Kreidberg, Mundel (bib22) 2004; 113 den Hertog, Ostman, Böhmer (bib60) 2008; 275 Cybulsky, Takano, Papillon, Guillemette, Herzenberg, Kennedy (bib18) 2010; 177 Shankland, Pippin, Reiser, Mundel (bib28) 2007; 72 Julien, Dubé, Read, Penney, Paquet, Han, Kennedy, Muller, Tremblay (bib13) 2007; 39 Hendriks, Elson, Harroch, Stoker (bib5) 2008; 275 Faul, Asanuma, Yanagida-Asanuma, Kim, Mundel (bib1) 2007; 17 Ruest, Roy, Shi, Mernaugh, Hanks (bib43) 2000; 11 Cheng, Uetani, Simoncic, Chaubey, Lee-Loy, McGlade, Kennedy, Tremblay (bib11) 2002; 2 Baylis (bib56) 1994; 94 Wei, Möller, Altintas, Li, Schwarz, Zacchigna, Xie, Henger, Schmid, Rastaldi, Cowan, Kretzler, Parrilla, Bendayan, Gupta, Nikolic, Kalluri, Carmeliet, Mundel, Reiser (bib3) 2008; 14 Liang, Lee, Liang, Lawrence, Zhang (bib46) 2005; 280 Wharram, Goyal, Gillespie, Wiggins, Kershaw, Holzman, Dysko, Saunders, Samuelson, Wiggins (bib8) 2000; 106 Pippin, Brinkkoetter, Cormack-Aboud, Durvasula, Hauser, Kowalewska, Krofft, Logar, Marshall, Ohse, Shankland (bib31) 2009; 296 Salazar, Rozengurt (bib34) 2001; 276 Reiser, Pixley, Hug, Kriz, Smoyer, Stanley, Mundel (bib9) 2000; 57 Thomas, Wharram, Goyal, Wiggins, Holzman, Wiggins (bib6) 1994; 269 Hall (10.1016/j.ajpath.2014.05.005_bib42) 2011; 288 Mundel (10.1016/j.ajpath.2014.05.005_bib2) 2010; 77 Nada (10.1016/j.ajpath.2014.05.005_bib35) 1993; 73 Yu (10.1016/j.ajpath.2014.05.005_bib58) 2013; 33 Alvira (10.1016/j.ajpath.2014.05.005_bib23) 2011; 286 Aoudjit (10.1016/j.ajpath.2014.05.005_bib16) 2011; 2011 Pippin (10.1016/j.ajpath.2014.05.005_bib31) 2009; 296 Logar (10.1016/j.ajpath.2014.05.005_bib52) 2007; 72 Burridge (10.1016/j.ajpath.2014.05.005_bib49) 2006; 281 Fukada (10.1016/j.ajpath.2014.05.005_bib63) 2003; 22 Van Beneden (10.1016/j.ajpath.2014.05.005_bib21) 2011; 22 Waters (10.1016/j.ajpath.2014.05.005_bib27) 2012; 23 Baylis (10.1016/j.ajpath.2014.05.005_bib56) 1994; 94 Mitra (10.1016/j.ajpath.2014.05.005_bib41) 2005; 6 Liu (10.1016/j.ajpath.2014.05.005_bib45) 1998; 8 Liu (10.1016/j.ajpath.2014.05.005_bib50) 1998; 18 Cybulsky (10.1016/j.ajpath.2014.05.005_bib18) 2010; 177 Thomas (10.1016/j.ajpath.2014.05.005_bib6) 1994; 269 Somani (10.1016/j.ajpath.2014.05.005_bib48) 1997; 272 Liang (10.1016/j.ajpath.2014.05.005_bib46) 2005; 280 Whitelaw (10.1016/j.ajpath.2014.05.005_bib59) 2001; 158 Tiganis (10.1016/j.ajpath.2014.05.005_bib39) 2007; 402 Shankland (10.1016/j.ajpath.2014.05.005_bib28) 2007; 72 Salazar (10.1016/j.ajpath.2014.05.005_bib34) 2001; 276 den Hertog (10.1016/j.ajpath.2014.05.005_bib60) 2008; 275 Morris (10.1016/j.ajpath.2014.05.005_bib12) 2009; 297 Salant (10.1016/j.ajpath.2014.05.005_bib24) 1988; 162 van den Berg (10.1016/j.ajpath.2014.05.005_bib25) 2004; 66 Arregui (10.1016/j.ajpath.2014.05.005_bib29) 1998; 143 Li (10.1016/j.ajpath.2014.05.005_bib26) 2004; 15 Verma (10.1016/j.ajpath.2014.05.005_bib38) 2006; 116 Hanks (10.1016/j.ajpath.2014.05.005_bib32) 2003; 8 Bridgewater (10.1016/j.ajpath.2014.05.005_bib51) 2008; 18 Wei (10.1016/j.ajpath.2014.05.005_bib3) 2008; 14 Reiser (10.1016/j.ajpath.2014.05.005_bib22) 2004; 113 Jones (10.1016/j.ajpath.2014.05.005_bib54) 2006; 440 Zhu (10.1016/j.ajpath.2014.05.005_bib19) 2008; 73 Attias (10.1016/j.ajpath.2014.05.005_bib20) 2010; 114 Uchida (10.1016/j.ajpath.2014.05.005_bib55) 2008; 73 Verhagen (10.1016/j.ajpath.2014.05.005_bib57) 2000; 279 Wharram (10.1016/j.ajpath.2014.05.005_bib8) 2000; 106 Ruest (10.1016/j.ajpath.2014.05.005_bib43) 2000; 11 Bourdeau (10.1016/j.ajpath.2014.05.005_bib61) 2005; 17 Verma (10.1016/j.ajpath.2014.05.005_bib37) 2003; 278 Liu (10.1016/j.ajpath.2014.05.005_bib44) 1996; 271 Koren (10.1016/j.ajpath.2014.05.005_bib64) 2007; 21 Hendriks (10.1016/j.ajpath.2014.05.005_bib5) 2008; 275 Julien (10.1016/j.ajpath.2014.05.005_bib13) 2007; 39 Faul (10.1016/j.ajpath.2014.05.005_bib1) 2007; 17 Reiser (10.1016/j.ajpath.2014.05.005_bib9) 2000; 57 Fukada (10.1016/j.ajpath.2014.05.005_bib62) 2001; 276 Delibegovic (10.1016/j.ajpath.2014.05.005_bib17) 2007; 27 Li (10.1016/j.ajpath.2014.05.005_bib53) 2006; 349 Elchebly (10.1016/j.ajpath.2014.05.005_bib10) 1999; 283 Erbe (10.1016/j.ajpath.2014.05.005_bib15) 2009; 11 Wang (10.1016/j.ajpath.2014.05.005_bib7) 2000; 57 Brown (10.1016/j.ajpath.2014.05.005_bib36) 1996; 1287 Yip (10.1016/j.ajpath.2014.05.005_bib14) 2010; 35 Burdisso (10.1016/j.ajpath.2014.05.005_bib47) 2013; 126 Kang (10.1016/j.ajpath.2014.05.005_bib40) 2010; 78 Ma (10.1016/j.ajpath.2014.05.005_bib4) 2010; 21 Bence (10.1016/j.ajpath.2014.05.005_bib30) 2006; 12 Stuible (10.1016/j.ajpath.2014.05.005_bib65) 2008; 27 Cheng (10.1016/j.ajpath.2014.05.005_bib11) 2002; 2 Klinghoffer (10.1016/j.ajpath.2014.05.005_bib33) 1999; 18 |
References_xml | – volume: 113 start-page: 1390 year: 2004 end-page: 1397 ident: bib22 article-title: Induction of B7-1 in podocytes is associated with nephrotic syndrome publication-title: J Clin Invest contributor: fullname: Mundel – volume: 126 start-page: 1820 year: 2013 end-page: 1831 ident: bib47 article-title: PTP1B promotes focal complex maturation, lamellar persistence and directional migration publication-title: J Cell Sci contributor: fullname: Arregui – volume: 6 start-page: 56 year: 2005 end-page: 68 ident: bib41 article-title: Focal adhesion kinase: in command and control of cell motility publication-title: Nat Rev Mol Cell Biol contributor: fullname: Schlaepfer – volume: 177 start-page: 2290 year: 2010 end-page: 2299 ident: bib18 article-title: Podocyte injury and albuminuria in mice with podocyte-specific overexpression of the Ste20-like kinase, SLK publication-title: Am J Pathol contributor: fullname: Kennedy – volume: 114 start-page: e93 year: 2010 end-page: e106 ident: bib20 article-title: Rac1 contributes to actin organization in glomerular podocytes publication-title: Nephron Exp Nephrol contributor: fullname: Takano – volume: 18 start-page: 250 year: 1998 end-page: 259 ident: bib50 article-title: Transformation suppression by protein tyrosine phosphatase 1B requires a functional SH3 ligand publication-title: Mol Cell Biol contributor: fullname: Chernoff – volume: 269 start-page: 19953 year: 1994 end-page: 19962 ident: bib6 article-title: GLEPP1, a renal glomerular epithelial cell (podocyte) membrane protein-tyrosine phosphatase. Identification, molecular cloning, and characterization in rabbit publication-title: J Biol Chem contributor: fullname: Wiggins – volume: 15 start-page: 3006 year: 2004 end-page: 3015 ident: bib26 article-title: SRC-family kinase Fyn phosphorylates the cytoplasmic domain of nephrin and modulates its interaction with podocin publication-title: J Am Soc Nephrol contributor: fullname: Takano – volume: 2011 start-page: 376543 year: 2011 ident: bib16 article-title: Podocyte protein, nephrin, is a substrate of protein tyrosine phosphatase 1B publication-title: J Signal Transduct contributor: fullname: Takano – volume: 106 start-page: 1281 year: 2000 end-page: 1290 ident: bib8 article-title: Altered podocyte structure in GLEPP1 (Ptpro)-deficient mice associated with hypertension and low glomerular filtration rate publication-title: J Clin Invest contributor: fullname: Wiggins – volume: 66 start-page: 1901 year: 2004 end-page: 1906 ident: bib25 article-title: Podocyte foot process effacement is not correlated with the level of proteinuria in human glomerulopathies publication-title: Kidney Int contributor: fullname: Florquin – volume: 11 start-page: 41 year: 2000 end-page: 48 ident: bib43 article-title: Phosphospecific antibodies reveal focal adhesion kinase activation loop phosphorylation in nascent and mature focal adhesions and requirement for the autophosphorylation site publication-title: Cell Growth Differ contributor: fullname: Hanks – volume: 276 start-page: 17788 year: 2001 end-page: 17795 ident: bib34 article-title: Src family kinases are required for integrin-mediated but not for G protein-coupled receptor stimulation of focal adhesion kinase autophosphorylation at Tyr-397 publication-title: J Biol Chem contributor: fullname: Rozengurt – volume: 39 start-page: 338 year: 2007 end-page: 346 ident: bib13 article-title: Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis publication-title: Nat Genet contributor: fullname: Tremblay – volume: 297 start-page: E1247 year: 2009 end-page: E1259 ident: bib12 article-title: Recent advances in understanding leptin signaling and leptin resistance publication-title: Am J Physiol Endocrinol Metab contributor: fullname: Rui – volume: 158 start-page: 351 year: 2001 end-page: 368 ident: bib59 article-title: Epigenetic effects on transgene expression publication-title: Methods Mol Biol contributor: fullname: Garrick – volume: 27 start-page: 7727 year: 2007 end-page: 7734 ident: bib17 article-title: Improved glucose homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1B publication-title: Mol Cell Biol contributor: fullname: Neel – volume: 72 start-page: 489 year: 2007 end-page: 498 ident: bib52 article-title: Darbepoetin alfa protects podocytes from apoptosis in vitro and in vivo publication-title: Kidney Int contributor: fullname: Shankland – volume: 21 start-page: 621 year: 2007 end-page: 640 ident: bib64 article-title: Inhibition of the protein tyrosine phosphatase PTP1B: potential therapy for obesity, insulin resistance and type-2 diabetes mellitus publication-title: Best Pract Res Clin Endocrinol Metab contributor: fullname: Fantus – volume: 23 start-page: 27 year: 2012 end-page: 35 ident: bib27 article-title: Notch promotes dynamin-dependent endocytosis of nephrin publication-title: J Am Soc Nephrol contributor: fullname: Piscione – volume: 276 start-page: 25512 year: 2001 end-page: 25519 ident: bib62 article-title: The reciprocal role of Egr-1 and Sp family proteins in regulation of the PTP1B promoter in response to the p210 Bcr-Abl oncoprotein-tyrosine kinase publication-title: J Biol Chem contributor: fullname: Tonks – volume: 22 start-page: 479 year: 2003 end-page: 493 ident: bib63 article-title: Identification of YB-1 as a regulator of PTP1B expression: implications for regulation of insulin and cytokine signaling publication-title: EMBO J contributor: fullname: Tonks – volume: 18 start-page: 2459 year: 1999 end-page: 2471 ident: bib33 article-title: Src family kinases are required for integrin but not PDGFR signal transduction publication-title: EMBO J contributor: fullname: Soriano – volume: 275 start-page: 831 year: 2008 end-page: 847 ident: bib60 article-title: Protein tyrosine phosphatases: regulatory mechanisms publication-title: FEBS J contributor: fullname: Böhmer – volume: 73 start-page: 1125 year: 1993 end-page: 1135 ident: bib35 article-title: Constitutive activation of Src family kinases in mouse embryos that lack Csk publication-title: Cell contributor: fullname: Aizawa – volume: 275 start-page: 816 year: 2008 end-page: 830 ident: bib5 article-title: Protein tyrosine phosphatases: functional inferences from mouse models and human diseases publication-title: FEBS J contributor: fullname: Stoker – volume: 73 start-page: 926 year: 2008 end-page: 932 ident: bib55 article-title: Decreased tyrosine phosphorylation of nephrin in rat and human nephrosis publication-title: Kidney Int contributor: fullname: Nitta – volume: 143 start-page: 861 year: 1998 end-page: 873 ident: bib29 article-title: Impaired integrin-mediated adhesion and signaling in fibroblasts expressing a dominant-negative mutant PTP1B publication-title: J Cell Biol contributor: fullname: Lilien – volume: 281 start-page: 15593 year: 2006 end-page: 15596 ident: bib49 article-title: Regulation of cell adhesion by protein-tyrosine phosphatases. I. Cell-matrix adhesion publication-title: J Biol Chem contributor: fullname: Sallee – volume: 18 start-page: 26 year: 2008 end-page: 37 ident: bib51 article-title: The role of the type I insulin-like growth factor receptor (IGF-IR) in glomerular integrity publication-title: Growth Horm IGF Res contributor: fullname: Matsell – volume: 279 start-page: F664 year: 2000 end-page: F670 ident: bib57 article-title: Male gender increases sensitivity to proteinuria induced by mild NOS inhibition in rats: role of sex hormones publication-title: Am J Physiol Renal Physiol contributor: fullname: Joles – volume: 33 start-page: 4755 year: 2013 end-page: 4764 ident: bib58 article-title: Rac1 activation in podocytes induces rapid foot process effacement and proteinuria publication-title: Mol Cell Biol contributor: fullname: Akilesh – volume: 296 start-page: F213 year: 2009 end-page: F229 ident: bib31 article-title: Inducible rodent models of acquired podocyte diseases publication-title: Am J Physiol Renal Physiol contributor: fullname: Shankland – volume: 283 start-page: 1544 year: 1999 end-page: 1548 ident: bib10 article-title: Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene publication-title: Science contributor: fullname: Kennedy – volume: 78 start-page: 363 year: 2010 end-page: 373 ident: bib40 article-title: Inhibition of integrin-linked kinase blocks podocyte epithelial-mesenchymal transition and ameliorates proteinuria publication-title: Kidney Int contributor: fullname: Liu – volume: 440 start-page: 818 year: 2006 end-page: 823 ident: bib54 article-title: Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes publication-title: Nature contributor: fullname: Pawson – volume: 116 start-page: 1346 year: 2006 end-page: 1359 ident: bib38 article-title: Nephrin ectodomain engagement results in Src kinase activation, nephrin phosphorylation, Nck recruitment, and actin polymerization publication-title: J Clin Invest contributor: fullname: Holzman – volume: 1287 start-page: 121 year: 1996 end-page: 149 ident: bib36 article-title: Regulation, substrates and functions of src publication-title: Biochim Biophys Acta contributor: fullname: Cooper – volume: 27 start-page: 215 year: 2008 end-page: 230 ident: bib65 article-title: PTP1B and TC-PTP: regulators of transformation and tumorigenesis publication-title: Cancer Metastasis Rev contributor: fullname: Tremblay – volume: 17 start-page: 203 year: 2005 end-page: 209 ident: bib61 article-title: Cytoplasmic protein tyrosine phosphatases, regulation and function: the roles of PTP1B and TC-PTP publication-title: Curr Opin Cell Biol contributor: fullname: Tremblay – volume: 286 start-page: 32313 year: 2011 end-page: 32323 ident: bib23 article-title: Inhibition of protein-tyrosine phosphatase 1B (PTP1B) mediates ubiquitination and degradation of Bcr-Abl protein publication-title: J Biol Chem contributor: fullname: Cotter – volume: 162 start-page: 421 year: 1988 end-page: 461 ident: bib24 article-title: Experimental glomerulonephritis publication-title: Methods Enzymol contributor: fullname: Cybulsky – volume: 94 start-page: 1823 year: 1994 end-page: 1829 ident: bib56 article-title: Age-dependent glomerular damage in the rat. Dissociation between glomerular injury and both glomerular hypertension and hypertrophy. Male gender as a primary risk factor publication-title: J Clin Invest contributor: fullname: Baylis – volume: 11 start-page: 579 year: 2009 end-page: 588 ident: bib15 article-title: Prodrug delivery of novel PTP1B inhibitors to enhance insulin signalling publication-title: Diabetes Obes Metab contributor: fullname: Tobin – volume: 14 start-page: 55 year: 2008 end-page: 63 ident: bib3 article-title: Modification of kidney barrier function by the urokinase receptor publication-title: Nat Med contributor: fullname: Reiser – volume: 21 start-page: 1145 year: 2010 end-page: 1156 ident: bib4 article-title: Inhibition of podocyte FAK protects against proteinuria and foot process effacement publication-title: J Am Soc Nephrol contributor: fullname: Ishibe – volume: 72 start-page: 26 year: 2007 end-page: 36 ident: bib28 article-title: Podocytes in culture: past, present, and future publication-title: Kidney Int contributor: fullname: Mundel – volume: 402 start-page: 1 year: 2007 end-page: 15 ident: bib39 article-title: Protein tyrosine phosphatase function: the substrate perspective publication-title: Biochem J contributor: fullname: Bennett – volume: 278 start-page: 20716 year: 2003 end-page: 20723 ident: bib37 article-title: Fyn binds to and phosphorylates the kidney slit diaphragm component Nephrin publication-title: J Biol Chem contributor: fullname: Holzman – volume: 288 start-page: 185 year: 2011 end-page: 225 ident: bib42 article-title: Focal adhesion kinase: exploring Fak structure to gain insight into function publication-title: Int Rev Cell Mol Biol contributor: fullname: Schaller – volume: 2 start-page: 497 year: 2002 end-page: 503 ident: bib11 article-title: Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B publication-title: Dev Cell contributor: fullname: Tremblay – volume: 17 start-page: 428 year: 2007 end-page: 437 ident: bib1 article-title: Actin up: regulation of podocyte structure and function by components of the actin cytoskeleton publication-title: Trends Cell Biol contributor: fullname: Mundel – volume: 73 start-page: 556 year: 2008 end-page: 566 ident: bib19 article-title: Nephrin mediates actin reorganization via phosphoinositide 3-kinase in podocytes publication-title: Kidney Int contributor: fullname: Takano – volume: 349 start-page: 310 year: 2006 end-page: 316 ident: bib53 article-title: Rat nephrin modulates cell morphology via the adaptor protein Nck publication-title: Biochem Biophys Res Commun contributor: fullname: Takano – volume: 77 start-page: 571 year: 2010 end-page: 580 ident: bib2 article-title: Proteinuria: an enzymatic disease of the podocyte? publication-title: Kidney Int contributor: fullname: Reiser – volume: 280 start-page: 24857 year: 2005 end-page: 24863 ident: bib46 article-title: The role of protein-tyrosine phosphatase 1B in integrin signaling publication-title: J Biol Chem contributor: fullname: Zhang – volume: 35 start-page: 442 year: 2010 end-page: 449 ident: bib14 article-title: PTP1B: a double agent in metabolism and oncogenesis publication-title: Trends Biochem Sci contributor: fullname: Chernoff – volume: 271 start-page: 31290 year: 1996 end-page: 31295 ident: bib44 article-title: Direct binding of the proline-rich region of protein tyrosine phosphatase 1B to the Src homology 3 domain of p130(Cas) publication-title: J Biol Chem contributor: fullname: Chernoff – volume: 8 start-page: d982 year: 2003 end-page: d996 ident: bib32 article-title: Focal adhesion kinase signaling activities and their implications in the control of cell survival and motility publication-title: Front Biosci contributor: fullname: Brábek – volume: 22 start-page: 1863 year: 2011 end-page: 1875 ident: bib21 article-title: Valproic acid attenuates proteinuria and kidney injury publication-title: J Am Soc Nephrol contributor: fullname: Van den Branden – volume: 12 start-page: 917 year: 2006 end-page: 924 ident: bib30 article-title: Neuronal PTP1B regulates body weight, adiposity and leptin action publication-title: Nat Med contributor: fullname: Kahn – volume: 57 start-page: 1847 year: 2000 end-page: 1859 ident: bib7 article-title: Molecular cloning, expression, and distribution of glomerular epithelial protein 1 in developing mouse kidney publication-title: Kidney Int contributor: fullname: Abrahamson – volume: 8 start-page: 173 year: 1998 end-page: 176 ident: bib45 article-title: Protein tyrosine phosphatase 1B negatively regulates integrin signaling publication-title: Curr Biol contributor: fullname: Chernoff – volume: 272 start-page: 21113 year: 1997 end-page: 21119 ident: bib48 article-title: Src kinase activity is regulated by the SHP-1 protein-tyrosine phosphatase publication-title: J Biol Chem contributor: fullname: Branch – volume: 57 start-page: 2035 year: 2000 end-page: 2042 ident: bib9 article-title: Regulation of mouse podocyte process dynamics by protein tyrosine phosphatases rapid communication publication-title: Kidney Int contributor: fullname: Mundel – volume: 296 start-page: F213 year: 2009 ident: 10.1016/j.ajpath.2014.05.005_bib31 article-title: Inducible rodent models of acquired podocyte diseases publication-title: Am J Physiol Renal Physiol doi: 10.1152/ajprenal.90421.2008 contributor: fullname: Pippin – volume: 276 start-page: 17788 year: 2001 ident: 10.1016/j.ajpath.2014.05.005_bib34 article-title: Src family kinases are required for integrin-mediated but not for G protein-coupled receptor stimulation of focal adhesion kinase autophosphorylation at Tyr-397 publication-title: J Biol Chem doi: 10.1074/jbc.M100984200 contributor: fullname: Salazar – volume: 78 start-page: 363 year: 2010 ident: 10.1016/j.ajpath.2014.05.005_bib40 article-title: Inhibition of integrin-linked kinase blocks podocyte epithelial-mesenchymal transition and ameliorates proteinuria publication-title: Kidney Int doi: 10.1038/ki.2010.137 contributor: fullname: Kang – volume: 158 start-page: 351 year: 2001 ident: 10.1016/j.ajpath.2014.05.005_bib59 article-title: Epigenetic effects on transgene expression publication-title: Methods Mol Biol contributor: fullname: Whitelaw – volume: 271 start-page: 31290 year: 1996 ident: 10.1016/j.ajpath.2014.05.005_bib44 article-title: Direct binding of the proline-rich region of protein tyrosine phosphatase 1B to the Src homology 3 domain of p130(Cas) publication-title: J Biol Chem doi: 10.1074/jbc.271.49.31290 contributor: fullname: Liu – volume: 162 start-page: 421 year: 1988 ident: 10.1016/j.ajpath.2014.05.005_bib24 article-title: Experimental glomerulonephritis publication-title: Methods Enzymol doi: 10.1016/0076-6879(88)62096-9 contributor: fullname: Salant – volume: 66 start-page: 1901 year: 2004 ident: 10.1016/j.ajpath.2014.05.005_bib25 article-title: Podocyte foot process effacement is not correlated with the level of proteinuria in human glomerulopathies publication-title: Kidney Int doi: 10.1111/j.1523-1755.2004.00964.x contributor: fullname: van den Berg – volume: 73 start-page: 926 year: 2008 ident: 10.1016/j.ajpath.2014.05.005_bib55 article-title: Decreased tyrosine phosphorylation of nephrin in rat and human nephrosis publication-title: Kidney Int doi: 10.1038/ki.2008.19 contributor: fullname: Uchida – volume: 283 start-page: 1544 year: 1999 ident: 10.1016/j.ajpath.2014.05.005_bib10 article-title: Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene publication-title: Science doi: 10.1126/science.283.5407.1544 contributor: fullname: Elchebly – volume: 143 start-page: 861 year: 1998 ident: 10.1016/j.ajpath.2014.05.005_bib29 article-title: Impaired integrin-mediated adhesion and signaling in fibroblasts expressing a dominant-negative mutant PTP1B publication-title: J Cell Biol doi: 10.1083/jcb.143.3.861 contributor: fullname: Arregui – volume: 6 start-page: 56 year: 2005 ident: 10.1016/j.ajpath.2014.05.005_bib41 article-title: Focal adhesion kinase: in command and control of cell motility publication-title: Nat Rev Mol Cell Biol doi: 10.1038/nrm1549 contributor: fullname: Mitra – volume: 57 start-page: 2035 year: 2000 ident: 10.1016/j.ajpath.2014.05.005_bib9 article-title: Regulation of mouse podocyte process dynamics by protein tyrosine phosphatases rapid communication publication-title: Kidney Int doi: 10.1046/j.1523-1755.2000.00070.x contributor: fullname: Reiser – volume: 23 start-page: 27 year: 2012 ident: 10.1016/j.ajpath.2014.05.005_bib27 article-title: Notch promotes dynamin-dependent endocytosis of nephrin publication-title: J Am Soc Nephrol doi: 10.1681/ASN.2011010027 contributor: fullname: Waters – volume: 33 start-page: 4755 year: 2013 ident: 10.1016/j.ajpath.2014.05.005_bib58 article-title: Rac1 activation in podocytes induces rapid foot process effacement and proteinuria publication-title: Mol Cell Biol doi: 10.1128/MCB.00730-13 contributor: fullname: Yu – volume: 269 start-page: 19953 year: 1994 ident: 10.1016/j.ajpath.2014.05.005_bib6 article-title: GLEPP1, a renal glomerular epithelial cell (podocyte) membrane protein-tyrosine phosphatase. Identification, molecular cloning, and characterization in rabbit publication-title: J Biol Chem doi: 10.1016/S0021-9258(17)32113-0 contributor: fullname: Thomas – volume: 297 start-page: E1247 year: 2009 ident: 10.1016/j.ajpath.2014.05.005_bib12 article-title: Recent advances in understanding leptin signaling and leptin resistance publication-title: Am J Physiol Endocrinol Metab doi: 10.1152/ajpendo.00274.2009 contributor: fullname: Morris – volume: 286 start-page: 32313 year: 2011 ident: 10.1016/j.ajpath.2014.05.005_bib23 article-title: Inhibition of protein-tyrosine phosphatase 1B (PTP1B) mediates ubiquitination and degradation of Bcr-Abl protein publication-title: J Biol Chem doi: 10.1074/jbc.M111.249060 contributor: fullname: Alvira – volume: 35 start-page: 442 year: 2010 ident: 10.1016/j.ajpath.2014.05.005_bib14 article-title: PTP1B: a double agent in metabolism and oncogenesis publication-title: Trends Biochem Sci doi: 10.1016/j.tibs.2010.03.004 contributor: fullname: Yip – volume: 14 start-page: 55 year: 2008 ident: 10.1016/j.ajpath.2014.05.005_bib3 article-title: Modification of kidney barrier function by the urokinase receptor publication-title: Nat Med doi: 10.1038/nm1696 contributor: fullname: Wei – volume: 15 start-page: 3006 year: 2004 ident: 10.1016/j.ajpath.2014.05.005_bib26 article-title: SRC-family kinase Fyn phosphorylates the cytoplasmic domain of nephrin and modulates its interaction with podocin publication-title: J Am Soc Nephrol doi: 10.1097/01.ASN.0000146689.88078.80 contributor: fullname: Li – volume: 349 start-page: 310 year: 2006 ident: 10.1016/j.ajpath.2014.05.005_bib53 article-title: Rat nephrin modulates cell morphology via the adaptor protein Nck publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2006.08.053 contributor: fullname: Li – volume: 116 start-page: 1346 year: 2006 ident: 10.1016/j.ajpath.2014.05.005_bib38 article-title: Nephrin ectodomain engagement results in Src kinase activation, nephrin phosphorylation, Nck recruitment, and actin polymerization publication-title: J Clin Invest doi: 10.1172/JCI27414 contributor: fullname: Verma – volume: 17 start-page: 428 year: 2007 ident: 10.1016/j.ajpath.2014.05.005_bib1 article-title: Actin up: regulation of podocyte structure and function by components of the actin cytoskeleton publication-title: Trends Cell Biol doi: 10.1016/j.tcb.2007.06.006 contributor: fullname: Faul – volume: 27 start-page: 7727 year: 2007 ident: 10.1016/j.ajpath.2014.05.005_bib17 article-title: Improved glucose homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1B publication-title: Mol Cell Biol doi: 10.1128/MCB.00959-07 contributor: fullname: Delibegovic – volume: 18 start-page: 2459 year: 1999 ident: 10.1016/j.ajpath.2014.05.005_bib33 article-title: Src family kinases are required for integrin but not PDGFR signal transduction publication-title: EMBO J doi: 10.1093/emboj/18.9.2459 contributor: fullname: Klinghoffer – volume: 17 start-page: 203 year: 2005 ident: 10.1016/j.ajpath.2014.05.005_bib61 article-title: Cytoplasmic protein tyrosine phosphatases, regulation and function: the roles of PTP1B and TC-PTP publication-title: Curr Opin Cell Biol doi: 10.1016/j.ceb.2005.02.001 contributor: fullname: Bourdeau – volume: 94 start-page: 1823 year: 1994 ident: 10.1016/j.ajpath.2014.05.005_bib56 article-title: Age-dependent glomerular damage in the rat. Dissociation between glomerular injury and both glomerular hypertension and hypertrophy. Male gender as a primary risk factor publication-title: J Clin Invest doi: 10.1172/JCI117531 contributor: fullname: Baylis – volume: 280 start-page: 24857 year: 2005 ident: 10.1016/j.ajpath.2014.05.005_bib46 article-title: The role of protein-tyrosine phosphatase 1B in integrin signaling publication-title: J Biol Chem doi: 10.1074/jbc.M502780200 contributor: fullname: Liang – volume: 21 start-page: 621 year: 2007 ident: 10.1016/j.ajpath.2014.05.005_bib64 article-title: Inhibition of the protein tyrosine phosphatase PTP1B: potential therapy for obesity, insulin resistance and type-2 diabetes mellitus publication-title: Best Pract Res Clin Endocrinol Metab doi: 10.1016/j.beem.2007.08.004 contributor: fullname: Koren – volume: 440 start-page: 818 year: 2006 ident: 10.1016/j.ajpath.2014.05.005_bib54 article-title: Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes publication-title: Nature doi: 10.1038/nature04662 contributor: fullname: Jones – volume: 73 start-page: 556 year: 2008 ident: 10.1016/j.ajpath.2014.05.005_bib19 article-title: Nephrin mediates actin reorganization via phosphoinositide 3-kinase in podocytes publication-title: Kidney Int doi: 10.1038/sj.ki.5002691 contributor: fullname: Zhu – volume: 276 start-page: 25512 year: 2001 ident: 10.1016/j.ajpath.2014.05.005_bib62 article-title: The reciprocal role of Egr-1 and Sp family proteins in regulation of the PTP1B promoter in response to the p210 Bcr-Abl oncoprotein-tyrosine kinase publication-title: J Biol Chem doi: 10.1074/jbc.M101354200 contributor: fullname: Fukada – volume: 275 start-page: 816 year: 2008 ident: 10.1016/j.ajpath.2014.05.005_bib5 article-title: Protein tyrosine phosphatases: functional inferences from mouse models and human diseases publication-title: FEBS J doi: 10.1111/j.1742-4658.2008.06249.x contributor: fullname: Hendriks – volume: 11 start-page: 579 year: 2009 ident: 10.1016/j.ajpath.2014.05.005_bib15 article-title: Prodrug delivery of novel PTP1B inhibitors to enhance insulin signalling publication-title: Diabetes Obes Metab doi: 10.1111/j.1463-1326.2008.01022.x contributor: fullname: Erbe – volume: 72 start-page: 489 year: 2007 ident: 10.1016/j.ajpath.2014.05.005_bib52 article-title: Darbepoetin alfa protects podocytes from apoptosis in vitro and in vivo publication-title: Kidney Int doi: 10.1038/sj.ki.5002362 contributor: fullname: Logar – volume: 72 start-page: 26 year: 2007 ident: 10.1016/j.ajpath.2014.05.005_bib28 article-title: Podocytes in culture: past, present, and future publication-title: Kidney Int doi: 10.1038/sj.ki.5002291 contributor: fullname: Shankland – volume: 126 start-page: 1820 year: 2013 ident: 10.1016/j.ajpath.2014.05.005_bib47 article-title: PTP1B promotes focal complex maturation, lamellar persistence and directional migration publication-title: J Cell Sci contributor: fullname: Burdisso – volume: 275 start-page: 831 year: 2008 ident: 10.1016/j.ajpath.2014.05.005_bib60 article-title: Protein tyrosine phosphatases: regulatory mechanisms publication-title: FEBS J doi: 10.1111/j.1742-4658.2008.06247.x contributor: fullname: den Hertog – volume: 18 start-page: 250 year: 1998 ident: 10.1016/j.ajpath.2014.05.005_bib50 article-title: Transformation suppression by protein tyrosine phosphatase 1B requires a functional SH3 ligand publication-title: Mol Cell Biol doi: 10.1128/MCB.18.1.250 contributor: fullname: Liu – volume: 279 start-page: F664 year: 2000 ident: 10.1016/j.ajpath.2014.05.005_bib57 article-title: Male gender increases sensitivity to proteinuria induced by mild NOS inhibition in rats: role of sex hormones publication-title: Am J Physiol Renal Physiol doi: 10.1152/ajprenal.2000.279.4.F664 contributor: fullname: Verhagen – volume: 8 start-page: 173 year: 1998 ident: 10.1016/j.ajpath.2014.05.005_bib45 article-title: Protein tyrosine phosphatase 1B negatively regulates integrin signaling publication-title: Curr Biol doi: 10.1016/S0960-9822(98)70066-1 contributor: fullname: Liu – volume: 278 start-page: 20716 year: 2003 ident: 10.1016/j.ajpath.2014.05.005_bib37 article-title: Fyn binds to and phosphorylates the kidney slit diaphragm component Nephrin publication-title: J Biol Chem doi: 10.1074/jbc.M301689200 contributor: fullname: Verma – volume: 22 start-page: 479 year: 2003 ident: 10.1016/j.ajpath.2014.05.005_bib63 article-title: Identification of YB-1 as a regulator of PTP1B expression: implications for regulation of insulin and cytokine signaling publication-title: EMBO J doi: 10.1093/emboj/cdg067 contributor: fullname: Fukada – volume: 177 start-page: 2290 year: 2010 ident: 10.1016/j.ajpath.2014.05.005_bib18 article-title: Podocyte injury and albuminuria in mice with podocyte-specific overexpression of the Ste20-like kinase, SLK publication-title: Am J Pathol doi: 10.2353/ajpath.2010.100263 contributor: fullname: Cybulsky – volume: 8 start-page: d982 year: 2003 ident: 10.1016/j.ajpath.2014.05.005_bib32 article-title: Focal adhesion kinase signaling activities and their implications in the control of cell survival and motility publication-title: Front Biosci doi: 10.2741/1114 contributor: fullname: Hanks – volume: 106 start-page: 1281 year: 2000 ident: 10.1016/j.ajpath.2014.05.005_bib8 article-title: Altered podocyte structure in GLEPP1 (Ptpro)-deficient mice associated with hypertension and low glomerular filtration rate publication-title: J Clin Invest doi: 10.1172/JCI7236 contributor: fullname: Wharram – volume: 12 start-page: 917 year: 2006 ident: 10.1016/j.ajpath.2014.05.005_bib30 article-title: Neuronal PTP1B regulates body weight, adiposity and leptin action publication-title: Nat Med doi: 10.1038/nm1435 contributor: fullname: Bence – volume: 57 start-page: 1847 year: 2000 ident: 10.1016/j.ajpath.2014.05.005_bib7 article-title: Molecular cloning, expression, and distribution of glomerular epithelial protein 1 in developing mouse kidney publication-title: Kidney Int doi: 10.1046/j.1523-1755.2000.00034.x contributor: fullname: Wang – volume: 402 start-page: 1 year: 2007 ident: 10.1016/j.ajpath.2014.05.005_bib39 article-title: Protein tyrosine phosphatase function: the substrate perspective publication-title: Biochem J doi: 10.1042/BJ20061548 contributor: fullname: Tiganis – volume: 1287 start-page: 121 year: 1996 ident: 10.1016/j.ajpath.2014.05.005_bib36 article-title: Regulation, substrates and functions of src publication-title: Biochim Biophys Acta contributor: fullname: Brown – volume: 22 start-page: 1863 year: 2011 ident: 10.1016/j.ajpath.2014.05.005_bib21 article-title: Valproic acid attenuates proteinuria and kidney injury publication-title: J Am Soc Nephrol doi: 10.1681/ASN.2010111196 contributor: fullname: Van Beneden – volume: 11 start-page: 41 year: 2000 ident: 10.1016/j.ajpath.2014.05.005_bib43 article-title: Phosphospecific antibodies reveal focal adhesion kinase activation loop phosphorylation in nascent and mature focal adhesions and requirement for the autophosphorylation site publication-title: Cell Growth Differ contributor: fullname: Ruest – volume: 27 start-page: 215 year: 2008 ident: 10.1016/j.ajpath.2014.05.005_bib65 article-title: PTP1B and TC-PTP: regulators of transformation and tumorigenesis publication-title: Cancer Metastasis Rev doi: 10.1007/s10555-008-9115-1 contributor: fullname: Stuible – volume: 21 start-page: 1145 year: 2010 ident: 10.1016/j.ajpath.2014.05.005_bib4 article-title: Inhibition of podocyte FAK protects against proteinuria and foot process effacement publication-title: J Am Soc Nephrol doi: 10.1681/ASN.2009090991 contributor: fullname: Ma – volume: 2 start-page: 497 year: 2002 ident: 10.1016/j.ajpath.2014.05.005_bib11 article-title: Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B publication-title: Dev Cell doi: 10.1016/S1534-5807(02)00149-1 contributor: fullname: Cheng – volume: 2011 start-page: 376543 year: 2011 ident: 10.1016/j.ajpath.2014.05.005_bib16 article-title: Podocyte protein, nephrin, is a substrate of protein tyrosine phosphatase 1B publication-title: J Signal Transduct doi: 10.1155/2011/376543 contributor: fullname: Aoudjit – volume: 39 start-page: 338 year: 2007 ident: 10.1016/j.ajpath.2014.05.005_bib13 article-title: Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis publication-title: Nat Genet doi: 10.1038/ng1963 contributor: fullname: Julien – volume: 77 start-page: 571 year: 2010 ident: 10.1016/j.ajpath.2014.05.005_bib2 article-title: Proteinuria: an enzymatic disease of the podocyte? publication-title: Kidney Int doi: 10.1038/ki.2009.424 contributor: fullname: Mundel – volume: 114 start-page: e93 year: 2010 ident: 10.1016/j.ajpath.2014.05.005_bib20 article-title: Rac1 contributes to actin organization in glomerular podocytes publication-title: Nephron Exp Nephrol doi: 10.1159/000262317 contributor: fullname: Attias – volume: 272 start-page: 21113 year: 1997 ident: 10.1016/j.ajpath.2014.05.005_bib48 article-title: Src kinase activity is regulated by the SHP-1 protein-tyrosine phosphatase publication-title: J Biol Chem doi: 10.1074/jbc.272.34.21113 contributor: fullname: Somani – volume: 18 start-page: 26 year: 2008 ident: 10.1016/j.ajpath.2014.05.005_bib51 article-title: The role of the type I insulin-like growth factor receptor (IGF-IR) in glomerular integrity publication-title: Growth Horm IGF Res doi: 10.1016/j.ghir.2007.06.003 contributor: fullname: Bridgewater – volume: 113 start-page: 1390 year: 2004 ident: 10.1016/j.ajpath.2014.05.005_bib22 article-title: Induction of B7-1 in podocytes is associated with nephrotic syndrome publication-title: J Clin Invest doi: 10.1172/JCI20402 contributor: fullname: Reiser – volume: 288 start-page: 185 year: 2011 ident: 10.1016/j.ajpath.2014.05.005_bib42 article-title: Focal adhesion kinase: exploring Fak structure to gain insight into function publication-title: Int Rev Cell Mol Biol doi: 10.1016/B978-0-12-386041-5.00005-4 contributor: fullname: Hall – volume: 73 start-page: 1125 year: 1993 ident: 10.1016/j.ajpath.2014.05.005_bib35 article-title: Constitutive activation of Src family kinases in mouse embryos that lack Csk publication-title: Cell doi: 10.1016/0092-8674(93)90642-4 contributor: fullname: Nada – volume: 281 start-page: 15593 year: 2006 ident: 10.1016/j.ajpath.2014.05.005_bib49 article-title: Regulation of cell adhesion by protein-tyrosine phosphatases. I. Cell-matrix adhesion publication-title: J Biol Chem doi: 10.1074/jbc.R500030200 contributor: fullname: Burridge |
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SubjectTerms | Animals Cell Movement - physiology Disease Models, Animal Enzyme Activation - physiology Female Fluorescent Antibody Technique Focal Adhesion Protein-Tyrosine Kinases - metabolism Gene Knockdown Techniques HEK293 Cells Humans Immunoblotting Male Mice Mice, Knockout Mice, Transgenic Nephrosis Pathology Phosphorylation Podocytes - enzymology Podocytes - pathology Protein Tyrosine Phosphatase, Non-Receptor Type 1 - antagonists & inhibitors Proteinuria - enzymology Proteinuria - pathology Rats Rats, Sprague-Dawley Reverse Transcriptase Polymerase Chain Reaction src-Family Kinases - metabolism |
Title | Protein Tyrosine Phosphatase 1B Inhibition Protects against Podocyte Injury and Proteinuria |
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