Estimation of Haplotype Frequencies, Linkage-Disequilibrium Measures, and Combination of Haplotype Copies in Each Pool by Use of Pooled DNA Data

• Published in: American journal of human genetics Vol. 72; no. 2; pp. 384 - 398
• Main Authors: Ito, Toshikazu, Chiku, Suenori, Inoue, Eisuke, Tomita, Makoto, Morisaki, Takayuki, Morisaki, Hiroko, Kamatani, Naoyuki
• Format: Journal Article
• Language: English
• Published: Chicago, IL Elsevier Inc 01.02.2003; University of Chicago Press; The American Society of Human Genetics
• Subjects: Algorithms; Alleles; Biological and medical sciences; Carrier Proteins - genetics; Classical genetics, quantitative genetics, hybrids; Computer Simulation; Cytoskeletal Proteins - genetics; Fundamental and applied biological sciences. Psychology; Gene Frequency - genetics; Genetic Linkage; Genetics of eukaryotes. Biological and molecular evolution; Genetics, Population; Genotype; Haplotypes - genetics; Human; Humans; Likelihood Functions; Linkage Disequilibrium - genetics; Lod Score; Methylenetetrahydrofolate Reductase (NADPH2); Muscle Proteins - genetics; Oxidoreductases Acting on CH-NH Group Donors - genetics; Polymorphism, Single Nucleotide; Serum Amyloid A Protein - genetics; Statistical analysis; Linkage; DNA; Estimation; Frequency; Genetics; Linkage equilibrium; Algorithm; Haplotype

Inference of haplotypes is important for many genetic approaches, including the process of assigning a phenotype to a genetic region. Usually, the population frequencies of haplotypes, as well as the diplotype configuration of each subject, are estimated from a set of genotypes of the subjects in a...