T Follicular Helper Cells Promote a Beneficial Gut Ecosystem for Host Metabolic Homeostasis by Sensing Microbiota-Derived Extracellular ATP

• Published in: Cell reports (Cambridge) Vol. 18; no. 11; pp. 2566 - 2575
• Main Authors: Perruzza, Lisa, Gargari, Giorgio, Proietti, Michele, Fosso, Bruno, D’Erchia, Anna Maria, Faliti, Caterina Elisa, Rezzonico-Jost, Tanja, Scribano, Daniela, Mauri, Laura, Colombo, Diego, Pellegrini, Giovanni, Moregola, Annalisa, Mooser, Catherine, Pesole, Graziano, Nicoletti, Mauro, Norata, Giuseppe Danilo, Geuking, Markus B., McCoy, Kathy D., Guglielmetti, Simone, Grassi, Fabio
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 14.03.2017; Cell Press; Elsevier
• Subjects: Adenosine Triphosphate - metabolism; Animals; ATP; Body Weight; Extracellular Space - metabolism; Gastrointestinal Microbiome - immunology; Glucose - metabolism; Homeostasis; IgA; Immunoglobulin A - metabolism; Intestine, Small - microbiology; metabolism; Mice, Inbred C57BL; microbiota; P2rx7; Receptors, Purinergic P2X7 - deficiency; Receptors, Purinergic P2X7 - metabolism; T follicular helper cells; T-Lymphocytes, Helper-Inducer - immunology; P2rx7; microbiota; IgA; metabolism; T follicular helper cells; ATP

The ATP-gated ionotropic P2X7 receptor regulates T follicular helper (Tfh) cell abundance in the Peyer’s patches (PPs) of the small intestine; deletion of P2rx7, encoding for P2X7, in Tfh cells results in enhanced IgA secretion and binding to commensal bacteria. Here, we show that Tfh cell activity...