The malaria parasite cation ATPase PfATP4 and its role in the mechanism of action of a new arsenal of antimalarial drugs

• Published in: International journal for parasitology -- drugs and drug resistance Vol. 5; no. 3; pp. 149 - 162
• Main Authors: Spillman, Natalie Jane, Kirk, Kiaran
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.12.2015; Elsevier
• Subjects: Antimalarial; Antimalarials - pharmacology; Calcium-Transporting ATPases - genetics; Calcium-Transporting ATPases - metabolism; Cipargamin; Drug discovery; Erythrocytes - metabolism; Erythrocytes - parasitology; Gene Expression Regulation, Enzymologic - drug effects; Humans; Invited Review; Malaria, Falciparum - drug therapy; Malaria, Falciparum - parasitology; PfATP4; Plasmodium; Plasmodium falciparum - drug effects; Plasmodium falciparum - enzymology; Resistance selection; Plasmodium; Antimalarial; PfATP4; Drug discovery; Resistance selection; Cipargamin

The intraerythrocytic malaria parasite, Plasmodium falciparum, maintains a low cytosolic Na+ concentration and the plasma membrane P-type cation translocating ATPase ‘PfATP4’ has been implicated as playing a key role in this process. PfATP4 has been the subject of significant attention in recent yea...