PPAR agonists for the treatment of primary biliary cholangitis: Old and new tales - Colapietro, Francesca; Gershwin, M. Eric; Lleo, Ana (Journal of translational autoimmunity (Online), 2023)
Keywords: Elafibranor; Fibrates; PPAR agonists; Primary biliary cholangitis; Review article; Saroglitazar; Seladelpar; UDCA; FF; PAR; FXR; FDA; RCT; PPAR agonists; ALP; LT; VAS; UDCA; HR; IgM; NRS; AEs; QoL; PBC; HDL; PPAR; AMA; LDL; ULN; UK; VRS; HSC; TLR; MDR3; CKD; AIH; OR; HCC; Seladelpar; IL-1β; NASH; OCA; BZF; PC; TNF-α; GGT; SAE; Primary biliary cholangitis; PH; Fibrates; Saroglitazar; Elafibranor; TGR; LT, Liver Transplant; PBC, Primary Biliary Cholangitis; MDR3, multidrug resistance protein 3; UK, United Kingdom; AEs, adverse events; FXR, Farnesoid X Receptor; NRS, Numerical Raing Scale; TNF-α, Tumor Necrosis Factor- α; IgM, Immunoglobulin M; PPAR, peroxisome proliferator-activated receptor; OCA, Obeticholic Acid; QoL, Quality of Life; BZF, Bezafibrate; SAE, Severe Adverse Event; ULN, upper limit of normal; TLR, Toll Like Receptor; RCT, randomized controlled trial; VRS, Verbal Rating Scale; IL-1β, Interleukin-1; VAS, Visual Analogue Scale; UDCA, ursodeoxycholic acid; CKD, chronic kidney disease; HR, Hazard Ratio; PC, phosphatidylcholine; HSC, Hepatic Stellate Cells; AMA, Antimitochondrial antibodies; NASH, Non Alcoholic Steato-Hepatits; ALP, Alkaline Phosphatase; FF, Fenofibrate; LDL, low-density- lipoprotein; GGT, γ-glutamil transferase; PAR, protease-activated receptors; FDA, Food and Drug; AIH, Autoimmune Hepatitis; PH, Portal Hypertension; TGR, transmembrane G protein-coupled receptor; HCC, Hepatocellular Carcinoma; HDL, high-density lipoprotein; OR, Odds Ratio