The Mitochondria-Regulated Immune Pathway Activated in the C. elegans Intestine Is Neuroprotective

• Published in: Cell reports (Cambridge) Vol. 16; no. 9; pp. 2399 - 2414
• Main Authors: Chikka, Madhusudana Rao, Anbalagan, Charumathi, Dvorak, Katherine, Dombeck, Kyle, Prahlad, Veena
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 30.08.2016; Elsevier
• Subjects: Activating Transcription Factors - genetics; Activating Transcription Factors - immunology; Animals; ATF-7; autophagy; Caenorhabditis elegans - drug effects; Caenorhabditis elegans - genetics; Caenorhabditis elegans - immunology; Caenorhabditis elegans Proteins - genetics; Caenorhabditis elegans Proteins - immunology; complex I; Dopamine - metabolism; Dopaminergic Neurons - drug effects; Dopaminergic Neurons - immunology; Dopaminergic Neurons - pathology; Electron Transport Complex I - deficiency; Electron Transport Complex I - genetics; Electron Transport Complex I - immunology; Epithelial Cells - drug effects; Epithelial Cells - immunology; Epithelial Cells - pathology; Gastrointestinal Tract - drug effects; Gastrointestinal Tract - immunology; Gastrointestinal Tract - pathology; Gene Expression Regulation; Immunity, Innate; innate immune response; mitochondria; Mitochondria - drug effects; Mitochondria - immunology; Mitochondria - pathology; Mitophagy - drug effects; Mitophagy - genetics; Nerve Degeneration - chemically induced; Nerve Degeneration - genetics; Nerve Degeneration - immunology; neurodegeneration; non-autonomous; p38 Mitogen-Activated Protein Kinases - genetics; p38 Mitogen-Activated Protein Kinases - immunology; p38MAPK; PINK-1; rotenone; Rotenone - toxicity; Signal Transduction; non-autonomous; autophagy; innate immune response; mitochondria; ATF-7; PINK-1; neurodegeneration; rotenone; complex I; p38MAPK
• ISSN: 2211-1247; 2211-1247
• DOI: 10.1016/j.celrep.2016.07.077

Immunological mediators that originate outside the nervous system can affect neuronal health. However, their roles in neurodegeneration remain largely unknown. Here, we show that the p38MAPK-mediated immune pathway activated in intestinal cells of Caenorhabditis elegans upon mitochondrial dysfunctio...