Human megakaryocytes possess intrinsic antiviral immunity through regulated induction of IFITM3

Evolving evidence indicates that platelets and megakaryocytes (MKs) have unexpected activities in inflammation and infection; whether viral infections upregulate biologically active, antiviral immune genes in platelets and MKs is unknown, however. We examined antiviral immune genes in these cells in...

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Published inBlood Vol. 133; no. 19; pp. 2013 - 2026
Main Authors Campbell, Robert A., Schwertz, Hansjorg, Hottz, Eugenio D., Rowley, Jesse W., Manne, Bhanu Kanth, Washington, A. Valance, Hunter-Mellado, Robert, Tolley, Neal D., Christensen, Miles, Eustes, Alicia S., Montenont, Emilie, Bhatlekar, Seema, Ventrone, Cassandra H., Kirkpatrick, Beth D., Pierce, Kristen K., Whitehead, Stephen S., Diehl, Sean A., Bray, Paul F., Zimmerman, Guy A., Kosaka, Yasuhiro, Bozza, Patricia T., Bozza, Fernando A., Weyrich, Andrew S., Rondina, Matthew T.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 09.05.2019
American Society of Hematology
SeriesPlatelets and Thrombopoiesis
Subjects
Dengue - immunology
Dengue Vaccines - immunology
Humans
Immunity, Innate - immunology
Megakaryocytes - immunology
Membrane Proteins - immunology
Plenary Paper
RNA-Binding Proteins - immunology
Online AccessGet full text

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Abstract Evolving evidence indicates that platelets and megakaryocytes (MKs) have unexpected activities in inflammation and infection; whether viral infections upregulate biologically active, antiviral immune genes in platelets and MKs is unknown, however. We examined antiviral immune genes in these cells in dengue and influenza infections, viruses that are global public health threats. Using complementary biochemical, pharmacological, and genetic approaches, we examined the regulation and function of interferon-induced transmembrane protein 3 (IFITM3), an antiviral immune effector gene not previously studied in human platelets and MKs. IFITM3 was markedly upregulated in platelets isolated from patients during clinical influenza and dengue virus (DENV) infections. Lower IFITM3 expression in platelets correlated with increased illness severity and mortality in patients. Administering a live, attenuated DENV vaccine to healthy subjects significantly increased platelet IFITM3 expression. Infecting human MKs with DENV selectively increased type I interferons and IFITM3. Overexpression of IFITM3 in MKs was sufficient to prevent DENV infection. In naturally occurring, genetic loss-of-function studies, MKs from healthy subjects harboring a homozygous mutation in IFITM3 (rs12252-C, a common single-nucleotide polymorphism in areas of the world where DENV is endemic) were significantly more susceptible to DENV infection. DENV-induced MK secretion of interferons prevented infection of bystander MKs and hematopoietic stem cells. Thus, viral infections upregulate IFITM3 in human platelets and MKs, and IFITM3 expression is associated with adverse clinical outcomes. These observations establish, for the first time, that human MKs possess antiviral functions, preventing DENV infection of MKs and hematopoietic stem cells after local immune signaling. •Viral infections upregulate IFITM3 in human platelets and MKs, triggering rapid antiviral immune responses.•MKs are effective immune cells that prevent virus infection in naive MKs but also limit infection in bystander hematopoietic stem cells. [Display omitted]
AbstractList Evolving evidence indicates that platelets and megakaryocytes (MKs) have unexpected activities in inflammation and infection; whether viral infections upregulate biologically active, antiviral immune genes in platelets and MKs is unknown, however. We examined antiviral immune genes in these cells in dengue and influenza infections, viruses that are global public health threats. Using complementary biochemical, pharmacological, and genetic approaches, we examined the regulation and function of interferon-induced transmembrane protein 3 (IFITM3), an antiviral immune effector gene not previously studied in human platelets and MKs. IFITM3 was markedly upregulated in platelets isolated from patients during clinical influenza and dengue virus (DENV) infections. Lower IFITM3 expression in platelets correlated with increased illness severity and mortality in patients. Administering a live, attenuated DENV vaccine to healthy subjects significantly increased platelet IFITM3 expression. Infecting human MKs with DENV selectively increased type I interferons and IFITM3. Overexpression of IFITM3 in MKs was sufficient to prevent DENV infection. In naturally occurring, genetic loss-of-function studies, MKs from healthy subjects harboring a homozygous mutation in IFITM3 (rs12252-C, a common single-nucleotide polymorphism in areas of the world where DENV is endemic) were significantly more susceptible to DENV infection. DENV-induced MK secretion of interferons prevented infection of bystander MKs and hematopoietic stem cells. Thus, viral infections upregulate IFITM3 in human platelets and MKs, and IFITM3 expression is associated with adverse clinical outcomes. These observations establish, for the first time, that human MKs possess antiviral functions, preventing DENV infection of MKs and hematopoietic stem cells after local immune signaling.
Publisher's Note: There is a Blood Commentary on this article in this issue. Viral infections upregulate IFITM3 in human platelets and MKs, triggering rapid antiviral immune responses. MKs are effective immune cells that prevent virus infection in naive MKs but also limit infection in bystander hematopoietic stem cells. Evolving evidence indicates that platelets and megakaryocytes (MKs) have unexpected activities in inflammation and infection; whether viral infections upregulate biologically active, antiviral immune genes in platelets and MKs is unknown, however. We examined antiviral immune genes in these cells in dengue and influenza infections, viruses that are global public health threats. Using complementary biochemical, pharmacological, and genetic approaches, we examined the regulation and function of interferon-induced transmembrane protein 3 (IFITM3), an antiviral immune effector gene not previously studied in human platelets and MKs. IFITM3 was markedly upregulated in platelets isolated from patients during clinical influenza and dengue virus (DENV) infections. Lower IFITM3 expression in platelets correlated with increased illness severity and mortality in patients. Administering a live, attenuated DENV vaccine to healthy subjects significantly increased platelet IFITM3 expression. Infecting human MKs with DENV selectively increased type I interferons and IFITM3. Overexpression of IFITM3 in MKs was sufficient to prevent DENV infection. In naturally occurring, genetic loss-of-function studies, MKs from healthy subjects harboring a homozygous mutation in IFITM3 (rs12252-C, a common single-nucleotide polymorphism in areas of the world where DENV is endemic) were significantly more susceptible to DENV infection. DENV-induced MK secretion of interferons prevented infection of bystander MKs and hematopoietic stem cells. Thus, viral infections upregulate IFITM3 in human platelets and MKs, and IFITM3 expression is associated with adverse clinical outcomes. These observations establish, for the first time, that human MKs possess antiviral functions, preventing DENV infection of MKs and hematopoietic stem cells after local immune signaling.
Evolving evidence indicates that platelets and megakaryocytes (MKs) have unexpected activities in inflammation and infection; whether viral infections upregulate biologically active, antiviral immune genes in platelets and MKs is unknown, however. We examined antiviral immune genes in these cells in dengue and influenza infections, viruses that are global public health threats. Using complementary biochemical, pharmacological, and genetic approaches, we examined the regulation and function of interferon-induced transmembrane protein 3 (IFITM3), an antiviral immune effector gene not previously studied in human platelets and MKs. IFITM3 was markedly upregulated in platelets isolated from patients during clinical influenza and dengue virus (DENV) infections. Lower IFITM3 expression in platelets correlated with increased illness severity and mortality in patients. Administering a live, attenuated DENV vaccine to healthy subjects significantly increased platelet IFITM3 expression. Infecting human MKs with DENV selectively increased type I interferons and IFITM3. Overexpression of IFITM3 in MKs was sufficient to prevent DENV infection. In naturally occurring, genetic loss-of-function studies, MKs from healthy subjects harboring a homozygous mutation in IFITM3 (rs12252-C, a common single-nucleotide polymorphism in areas of the world where DENV is endemic) were significantly more susceptible to DENV infection. DENV-induced MK secretion of interferons prevented infection of bystander MKs and hematopoietic stem cells. Thus, viral infections upregulate IFITM3 in human platelets and MKs, and IFITM3 expression is associated with adverse clinical outcomes. These observations establish, for the first time, that human MKs possess antiviral functions, preventing DENV infection of MKs and hematopoietic stem cells after local immune signaling. •Viral infections upregulate IFITM3 in human platelets and MKs, triggering rapid antiviral immune responses.•MKs are effective immune cells that prevent virus infection in naive MKs but also limit infection in bystander hematopoietic stem cells. [Display omitted]
Evolving evidence indicates that platelets and megakaryocytes (MKs) have unexpected activities in inflammation and infection; whether viral infections upregulate biologically active, antiviral immune genes in platelets and MKs is unknown, however. We examined antiviral immune genes in these cells in dengue and influenza infections, viruses that are global public health threats. Using complementary biochemical, pharmacological, and genetic approaches, we examined the regulation and function of interferon-induced transmembrane protein 3 (IFITM3), an antiviral immune effector gene not previously studied in human platelets and MKs. IFITM3 was markedly upregulated in platelets isolated from patients during clinical influenza and dengue virus (DENV) infections. Lower IFITM3 expression in platelets correlated with increased illness severity and mortality in patients. Administering a live, attenuated DENV vaccine to healthy subjects significantly increased platelet IFITM3 expression. Infecting human MKs with DENV selectively increased type I interferons and IFITM3. Overexpression of IFITM3 in MKs was sufficient to prevent DENV infection. In naturally occurring, genetic loss-of-function studies, MKs from healthy subjects harboring a homozygous mutation in IFITM3 (rs12252-C, a common single-nucleotide polymorphism in areas of the world where DENV is endemic) were significantly more susceptible to DENV infection. DENV-induced MK secretion of interferons prevented infection of bystander MKs and hematopoietic stem cells. Thus, viral infections upregulate IFITM3 in human platelets and MKs, and IFITM3 expression is associated with adverse clinical outcomes. These observations establish, for the first time, that human MKs possess antiviral functions, preventing DENV infection of MKs and hematopoietic stem cells after local immune signaling.Evolving evidence indicates that platelets and megakaryocytes (MKs) have unexpected activities in inflammation and infection; whether viral infections upregulate biologically active, antiviral immune genes in platelets and MKs is unknown, however. We examined antiviral immune genes in these cells in dengue and influenza infections, viruses that are global public health threats. Using complementary biochemical, pharmacological, and genetic approaches, we examined the regulation and function of interferon-induced transmembrane protein 3 (IFITM3), an antiviral immune effector gene not previously studied in human platelets and MKs. IFITM3 was markedly upregulated in platelets isolated from patients during clinical influenza and dengue virus (DENV) infections. Lower IFITM3 expression in platelets correlated with increased illness severity and mortality in patients. Administering a live, attenuated DENV vaccine to healthy subjects significantly increased platelet IFITM3 expression. Infecting human MKs with DENV selectively increased type I interferons and IFITM3. Overexpression of IFITM3 in MKs was sufficient to prevent DENV infection. In naturally occurring, genetic loss-of-function studies, MKs from healthy subjects harboring a homozygous mutation in IFITM3 (rs12252-C, a common single-nucleotide polymorphism in areas of the world where DENV is endemic) were significantly more susceptible to DENV infection. DENV-induced MK secretion of interferons prevented infection of bystander MKs and hematopoietic stem cells. Thus, viral infections upregulate IFITM3 in human platelets and MKs, and IFITM3 expression is associated with adverse clinical outcomes. These observations establish, for the first time, that human MKs possess antiviral functions, preventing DENV infection of MKs and hematopoietic stem cells after local immune signaling.
Author Pierce, Kristen K.
Bray, Paul F.
Manne, Bhanu Kanth
Rowley, Jesse W.
Ventrone, Cassandra H.
Diehl, Sean A.
Tolley, Neal D.
Kirkpatrick, Beth D.
Rondina, Matthew T.
Bozza, Fernando A.
Washington, A. Valance
Christensen, Miles
Campbell, Robert A.
Bhatlekar, Seema
Zimmerman, Guy A.
Bozza, Patricia T.
Whitehead, Stephen S.
Schwertz, Hansjorg
Hunter-Mellado, Robert
Montenont, Emilie
Hottz, Eugenio D.
Weyrich, Andrew S.
Eustes, Alicia S.
Kosaka, Yasuhiro
Author_xml – sequence: 1
  givenname: Robert A.
  surname: Campbell
  fullname: Campbell, Robert A.
  organization: University of Utah Molecular Medicine Program, Salt Lake City, UT
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  surname: Schwertz
  fullname: Schwertz, Hansjorg
  organization: University of Utah Molecular Medicine Program, Salt Lake City, UT
– sequence: 3
  givenname: Eugenio D.
  surname: Hottz
  fullname: Hottz, Eugenio D.
  organization: University of Utah Molecular Medicine Program, Salt Lake City, UT
– sequence: 4
  givenname: Jesse W.
  surname: Rowley
  fullname: Rowley, Jesse W.
  organization: University of Utah Molecular Medicine Program, Salt Lake City, UT
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  givenname: Bhanu Kanth
  surname: Manne
  fullname: Manne, Bhanu Kanth
  organization: University of Utah Molecular Medicine Program, Salt Lake City, UT
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  organization: Department of Biology, University of Puerto Rico–Rio Piedras, San Juan, Puerto Rico
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  surname: Tolley
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  organization: University of Utah Molecular Medicine Program, Salt Lake City, UT
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  surname: Christensen
  fullname: Christensen, Miles
  organization: Department of Internal Medicine, University of Utah, Salt Lake City, UT
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  organization: University of Utah Molecular Medicine Program, Salt Lake City, UT
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  organization: University of Utah Molecular Medicine Program, Salt Lake City, UT
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  organization: University of Utah Molecular Medicine Program, Salt Lake City, UT
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  givenname: Cassandra H.
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  fullname: Ventrone, Cassandra H.
  organization: Vaccine Testing Center, Department of Microbiology and Molecular Genetics, University of Vermont Larner College of Medicine, Burlington, VT
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  organization: University of Utah Molecular Medicine Program, Salt Lake City, UT
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  organization: University of Utah Molecular Medicine Program, Salt Lake City, UT
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  surname: Kosaka
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  email: matthew.rondina@hsc.utah.edu
  organization: University of Utah Molecular Medicine Program, Salt Lake City, UT
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30723081$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1016/j.exphem.2011.11.011
10.1038/nature21706
10.1182/blood-2013-07-515536
10.1128/CVI.00613-15
10.1172/JCI84598
10.1590/0074-02760150453
10.1016/j.chom.2015.04.005
10.1161/CIRCRESAHA.113.300512
10.1309/AJCP35KOZSAVNQZW
10.1182/blood-2013-05-504449
10.1016/j.prp.2010.11.003
10.1016/j.jcv.2014.04.002
10.3390/v9080223
10.1016/j.jcv.2017.10.010
10.1378/chest.11-2860
10.1056/NEJMoa1304459
10.1371/journal.ppat.1006385
10.1128/JVI.01156-13
10.1128/JVI.74.11.4957-4966.2000
10.1016/j.cell.2009.12.017
10.1126/science.270.5243.1811
10.1182/blood-2015-07-661371
10.4049/jimmunol.1400091
10.1182/blood.V78.8.2062.2062
10.1038/srep41697
10.4269/ajtmh.12-0023
10.1016/j.cell.2017.11.001
10.1161/ATVBAHA.117.310552
10.1016/j.it.2004.07.003
10.1111/jth.12178
10.1093/cid/ciq125
10.1182/blood-2014-09-598029
10.1056/NEJMcibr1005904
10.5501/wjv.v2.i2.91
10.4049/jimmunol.1200580
10.1016/S0140-6736(14)60572-9
10.1089/bsp.2010.0032
10.1093/infdis/jiv082
10.1038/nri2956
10.1084/jem.20061302
10.1111/jth.13281
10.1371/journal.ppat.1002355
10.1371/journal.ppat.1002337
10.1182/bloodadvances.2017007021
10.1038/nature10921
10.1016/S0950-3536(05)80240-9
10.1016/j.cell.2015.12.027
10.1038/ncomms2433
10.1073/pnas.1207314109
10.4269/ajtmh.1993.48.222
10.1371/journal.pone.0002985
10.1186/1742-4690-10-48
10.1111/j.1538-7836.2011.04530.x
10.1371/journal.pone.0052902
10.1371/journal.pone.0083386
10.1371/journal.pntd.0002858
10.1161/ATVBAHA.117.309794
10.1006/meth.2001.1262
10.1038/nature06246
10.4269/ajtmh.2009.80.841
10.1007/s00281-011-0286-4
10.4049/jimmunol.1700885
10.1038/nrmicro3269
10.1016/j.ddmec.2011.09.001
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References Schmidt (bib2) 2010; 363
Harms, Schmidt, Smith (bib59) 2010; 134
Calore, Uip, Perez (bib60) 2011; 207
Hottz, Lopes, Freitas (bib16) 2013; 122
Zufferey, Speck, Machlus (bib40) 2017; 1
Schwertz, Rowley, Schumann (bib21) 2018; 38
Gibellini, Clò, Morini, Miserocchi, Ponti, Re (bib58) 2013; 2
Hottz, Medeiros-de-Moraes, Vieira-de-Abreu (bib54) 2014; 193
Monté, Wietzerbin, Pancré (bib48) 1991; 78
Schwertz, Tolley, Foulks (bib15) 2006; 203
Boilard, Paré, Rousseau (bib28) 2014; 123
Weyrich, Zimmerman (bib7) 2004; 25
Franco, Hynes, Bouri, Henderson (bib5) 2010; 8
de la Cruz-Hernández, Flores-Aguilar, González-Mateos (bib55) 2013; 88
Rowley, Chappaz, Corduan (bib20) 2016; 127
Póvoa, Alves, Oliveira, Nuovo, Chagas, Paes (bib51) 2014; 9
Campbell, Vieira-de-Abreu, Rowley (bib19) 2017; 37
Rondina, Brewster, Grissom (bib27) 2012; 141
Ojha, Nandi, Batra (bib52) 2017; 7
Ng, Sullivan, Teijaro (bib65) 2015; 17
Hottz, Tolley, Zimmerman, Weyrich, Bozza (bib1) 2011; 8
Diamond, Roberts, Edgil, Lu, Ernst, Harris (bib23) 2000; 74
Zacour, Ward, Brewer, Public Health Agency of Canada and Canadian Institutes of Health Influenza Research Network (PCIRN) (bib29) 2016; 23
Bunce, High, Nadjafi, Stanley, Liles, Christian (bib61) 2011; 52
Brass, Huang, Benita (bib24) 2009; 139
Oliveira, Silva, Calzavara-Silva (bib35) 2016; 111
Simon, Sutherland, Pryzdial (bib34) 2015; 126
Hottz, Oliveira, Nunes (bib53) 2013; 11
Yeaman (bib41) 2014; 12
Lefrançais, Ortiz-Muñoz, Caudrillier (bib62) 2017; 544
Vieira-de-Abreu A, Rondina MT, Weyrich AS, Zimmerman GA,. Inflammation. In: Michelson AD, ed. Platelets. New York, NY: Elsevier; 2012:733-766.
Noisakran, Onlamoon, Hsiao (bib32) 2012; 40
Everitt, Clare, Pertel, MOSAIC Investigators (bib25) 2012; 484
Semple, Italiano, Freedman (bib9) 2011; 11
Kraemer, Campbell, Schwertz (bib13) 2011; 7
Clark, Noisakran, Onlamoon (bib30) 2012; 7
Honda, Saito, Dimaano (bib50) 2009; 80
Trugilho, Hottz, Brunoro (bib44) 2017; 13
Rondina, Freitag, Pluthero (bib17) 2016; 14
Feeley, Sims, John (bib26) 2011; 7
Shim, Kim, Tenson, Min, Kainov (bib45) 2017; 9
De La Cruz Hernández, Puerta-Guardo, Flores-Aguilar (bib36) 2014; 60
Cunin, Penke, Thon (bib63) 2017; 127
Livak, Schmittgen (bib22) 2001; 25
Zhang, Zhao, Li (bib37) 2013; 4
Yu, Gao, Feng (bib3) 2008; 3
Auerbach, Lin, Miao (bib38) 2012; 109
Gaertner, Ahmad, Rosenberger (bib12) 2017; 171
Campbell, Franks, Bhatnagar (bib18) 2018; 200
Negrotto, J De Giusti, Lapponi (bib49) 2011; 9
Talarico, Byrne, Amarilla (bib46) 2017; 97
Medzhitov (bib10) 2007; 449
Rondina, Weyrich, Zimmerman (bib11) 2013; 112
Guzman, Harris (bib47) 2015; 385
La Russa, Innis (bib31) 1995; 8
Gao, Cao, Hu (bib4) 2013; 368
Sridharan, Chen, Tang, Ooi, Hibberd, Chen (bib33) 2013; 87
Cocchi, DeVico, Garzino-Demo, Arya, Gallo, Lusso (bib43) 1995; 270
Zapata, Cox, Salvato (bib57) 2014; 8
Vieira-de-Abreu, Campbell, Weyrich, Zimmerman (bib8) 2012; 34
Chapman, Aggrey, Field (bib39) 2012; 189
Solomon Tsegaye, Gnirß, Rahe-Meyer (bib42) 2013; 10
Kurane, Innis, Nimmannitya, Nisalak, Meager, Ennis (bib56) 1993; 48
Ng, Mendoza, Garcia, Oldstone (bib64) 2016; 164
Kirkpatrick, Durbin, Pierce (bib14) 2015; 212
de la Cruz-Hernández (2020021109302182300_B55) 2013; 88
Campbell (2020021109302182300_B19) 2017; 37
Feeley (2020021109302182300_B26) 2011; 7
Sridharan (2020021109302182300_B33) 2013; 87
Lefrançais (2020021109302182300_B62) 2017; 544
Oliveira (2020021109302182300_B35) 2016; 111
Zufferey (2020021109302182300_B40) 2017; 1
Yeaman (2020021109302182300_B41) 2014; 12
Hottz (2020021109302182300_B53) 2013; 11
Vieira-de-Abreu (2020021109302182300_B8) 2012; 34
Zacour (2020021109302182300_B29) 2016; 23
Clark (2020021109302182300_B30) 2012; 7
Ng (2020021109302182300_B65) 2015; 17
Simon (2020021109302182300_B34) 2015; 126
Campbell (2020021109302182300_B18) 2018; 200
Yu (2020021109302182300_B3) 2008; 3
Shim (2020021109302182300_B45) 2017; 9
Honda (2020021109302182300_B50) 2009; 80
Zapata (2020021109302182300_B57) 2014; 8
Gibellini (2020021109302182300_B58) 2013; 2
Livak (2020021109302182300_B22) 2001; 25
Guzman (2020021109302182300_B47) 2015; 385
Rondina (2020021109302182300_B11) 2013; 112
Gao (2020021109302182300_B4) 2013; 368
Auerbach (2020021109302182300_B38) 2012; 109
Kraemer (2020021109302182300_B13) 2011; 7
La Russa (2020021109302182300_B31) 1995; 8
Solomon Tsegaye (2020021109302182300_B42) 2013; 10
Ojha (2020021109302182300_B52) 2017; 7
Schmidt (2020021109302182300_B2) 2010; 363
Weyrich (2020021109302182300_B7) 2004; 25
Bunce (2020021109302182300_B61) 2011; 52
Franco (2020021109302182300_B5) 2010; 8
Gaertner (2020021109302182300_B12) 2017; 171
Kirkpatrick (2020021109302182300_B14) 2015; 212
Schwertz (2020021109302182300_B21) 2018; 38
Hottz (2020021109302182300_B1) 2011; 8
Kurane (2020021109302182300_B56) 1993; 48
Chapman (2020021109302182300_B39) 2012; 189
Harms (2020021109302182300_B59) 2010; 134
Cunin (2020021109302182300_B63) 2017; 127
Monté (2020021109302182300_B48) 1991; 78
Calore (2020021109302182300_B60) 2011; 207
Zhang (2020021109302182300_B37) 2013; 4
Noisakran (2020021109302182300_B32) 2012; 40
Hottz (2020021109302182300_B54) 2014; 193
Rondina (2020021109302182300_B27) 2012; 141
Negrotto (2020021109302182300_B49) 2011; 9
Ng (2020021109302182300_B64) 2016; 164
Semple (2020021109302182300_B9) 2011; 11
Trugilho (2020021109302182300_B44) 2017; 13
Póvoa (2020021109302182300_B51) 2014; 9
Everitt (2020021109302182300_B25) 2012; 484
Talarico (2020021109302182300_B46) 2017; 97
Schwertz (2020021109302182300_B15) 2006; 203
Boilard (2020021109302182300_B28) 2014; 123
Cocchi (2020021109302182300_B43) 1995; 270
Rondina (2020021109302182300_B17) 2016; 14
Brass (2020021109302182300_B24) 2009; 139
Diamond (2020021109302182300_B23) 2000; 74
Vieira-de-Abreu (2020021109302182300_B6) 2012
Rowley (2020021109302182300_B20) 2016; 127
De La Cruz Hernández (2020021109302182300_B36) 2014; 60
Hottz (2020021109302182300_B16) 2013; 122
Medzhitov (2020021109302182300_B10) 2007; 449
31257735 - J Thromb Haemost. 2019 Jul;17(7):1013. doi: 10.1111/jth.14490
31072959 - Blood. 2019 May 9;133(19):2001-2002. doi: 10.1182/blood-2019-02-900787
References_xml – volume: 127
  start-page: 1743
  year: 2016
  end-page: 1751
  ident: bib20
  article-title: Dicer1-mediated miRNA processing shapes the mRNA profile and function of murine platelets
  publication-title: Blood
– volume: 3
  start-page: e2985
  year: 2008
  ident: bib3
  article-title: Clinical characteristics of 26 human cases of highly pathogenic avian influenza A (H5N1) virus infection in China
  publication-title: PLoS One
– volume: 17
  start-page: 653
  year: 2015
  end-page: 661
  ident: bib65
  article-title: Blockade of interferon beta, but not interferon alpha, signaling controls persistent viral infection
  publication-title: Cell Host Microbe
– volume: 449
  start-page: 819
  year: 2007
  end-page: 826
  ident: bib10
  article-title: Recognition of microorganisms and activation of the immune response
  publication-title: Nature
– volume: 141
  start-page: 1490
  year: 2012
  end-page: 1495
  ident: bib27
  article-title: In vivo platelet activation in critically ill patients with primary 2009 influenza A(H1N1)
  publication-title: Chest
– volume: 87
  start-page: 11648
  year: 2013
  end-page: 11658
  ident: bib33
  article-title: Inhibition of megakaryocyte development in the bone marrow underlies dengue virus-induced thrombocytopenia in humanized mice
  publication-title: J Virol
– volume: 13
  start-page: e1006385
  year: 2017
  ident: bib44
  article-title: Platelet proteome reveals novel pathways of platelet activation and platelet-mediated immunoregulation in dengue
  publication-title: PLoS Pathog
– volume: 52
  start-page: e14
  year: 2011
  end-page: e17
  ident: bib61
  article-title: Pandemic H1N1 influenza infection and vascular thrombosis
  publication-title: Clin Infect Dis
– volume: 34
  start-page: 5
  year: 2012
  end-page: 30
  ident: bib8
  article-title: Platelets: versatile effector cells in hemostasis, inflammation, and the immune continuum
  publication-title: Semin Immunopathol
– volume: 8
  start-page: e2858
  year: 2014
  ident: bib57
  article-title: The role of platelets in the pathogenesis of viral hemorrhagic fevers
  publication-title: PLoS Negl Trop Dis
– volume: 11
  start-page: 264
  year: 2011
  end-page: 274
  ident: bib9
  article-title: Platelets and the immune continuum
  publication-title: Nat Rev Immunol
– volume: 171
  start-page: 1368
  year: 2017
  end-page: 1382.23
  ident: bib12
  article-title: Migrating platelets are mechano-scavengers that collect and bundle bacteria
  publication-title: Cell
– volume: 11
  start-page: 951
  year: 2013
  end-page: 962
  ident: bib53
  article-title: Dengue induces platelet activation, mitochondrial dysfunction and cell death through mechanisms that involve DC-SIGN and caspases
  publication-title: J Thromb Haemost
– volume: 112
  start-page: 1506
  year: 2013
  end-page: 1519
  ident: bib11
  article-title: Platelets as cellular effectors of inflammation in vascular diseases
  publication-title: Circ Res
– volume: 88
  start-page: 446
  year: 2013
  end-page: 454
  ident: bib55
  article-title: Determination of viremia and concentration of circulating nonstructural protein 1 in patients infected with dengue virus in Mexico
  publication-title: Am J Trop Med Hyg
– volume: 484
  start-page: 519
  year: 2012
  end-page: 523
  ident: bib25
  article-title: IFITM3 restricts the morbidity and mortality associated with influenza
  publication-title: Nature
– volume: 122
  start-page: 3405
  year: 2013
  end-page: 3414
  ident: bib16
  article-title: Platelets mediate increased endothelium permeability in dengue through NLRP3-inflammasome activation
  publication-title: Blood
– volume: 37
  start-page: 1819
  year: 2017
  end-page: 1827
  ident: bib19
  article-title: Clots are potent triggers of inflammatory cell gene expression: indications for timely fibrinolysis
  publication-title: Arterioscler Thromb Vasc Biol
– volume: 25
  start-page: 489
  year: 2004
  end-page: 495
  ident: bib7
  article-title: Platelets: signaling cells in the immune continuum
  publication-title: Trends Immunol
– volume: 544
  start-page: 105
  year: 2017
  end-page: 109
  ident: bib62
  article-title: The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors
  publication-title: Nature
– volume: 111
  start-page: 378
  year: 2016
  end-page: 384
  ident: bib35
  article-title: Primary dengue haemorrhagic fever in patients from northeast of Brazil is associated with high levels of interferon-β during acute phase
  publication-title: Mem Inst Oswaldo Cruz
– volume: 127
  start-page: 1714
  year: 2017
  end-page: 1724
  ident: bib63
  article-title: Megakaryocytes compensate for Kit insufficiency in murine arthritis
  publication-title: J Clin Invest
– volume: 9
  start-page: e83386
  year: 2014
  ident: bib51
  article-title: The pathology of severe dengue in multiple organs of human fatal cases: histopathology, ultrastructure and virus replication
  publication-title: PLoS One
– volume: 80
  start-page: 841
  year: 2009
  end-page: 845
  ident: bib50
  article-title: Increased phagocytosis of platelets from patients with secondary dengue virus infection by human macrophages
  publication-title: Am J Trop Med Hyg
– volume: 207
  start-page: 86
  year: 2011
  end-page: 90
  ident: bib60
  article-title: Pathology of the swine-origin influenza A (H1N1) flu
  publication-title: Pathol Res Pract
– volume: 212
  start-page: 702
  year: 2015
  end-page: 710
  ident: bib14
  article-title: Robust and balanced immune responses to all 4 dengue virus serotypes following administration of a single dose of a live attenuated tetravalent dengue vaccine to healthy, flavivirus-naive adults
  publication-title: J Infect Dis
– volume: 164
  start-page: 349
  year: 2016
  end-page: 352
  ident: bib64
  article-title: Alpha and Beta Type 1 Interferon Signaling: Passage for Diverse Biologic Outcomes
  publication-title: Cell
– volume: 10
  start-page: 48
  year: 2013
  ident: bib42
  article-title: Platelet activation suppresses HIV-1 infection of T cells
  publication-title: Retrovirology
– volume: 78
  start-page: 2062
  year: 1991
  end-page: 2069
  ident: bib48
  article-title: Identification and characterization of a functional receptor for interferon-gamma on a megakaryocytic cell line
  publication-title: Blood
– volume: 4
  start-page: 1418
  year: 2013
  ident: bib37
  article-title: Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with severe influenza in Chinese individuals
  publication-title: Nat Commun
– volume: 97
  start-page: 10
  year: 2017
  end-page: 17
  ident: bib46
  article-title: Characterization of type I interferon responses in dengue and severe dengue in children in Paraguay
  publication-title: J Clin Virol
– volume: 368
  start-page: 1888
  year: 2013
  end-page: 1897
  ident: bib4
  article-title: Human infection with a novel avian-origin influenza A (H7N9) virus
  publication-title: N Engl J Med
– volume: 25
  start-page: 402
  year: 2001
  end-page: 408
  ident: bib22
  article-title: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method
  publication-title: Methods
– volume: 270
  start-page: 1811
  year: 1995
  end-page: 1815
  ident: bib43
  article-title: Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells
  publication-title: Science
– volume: 7
  start-page: e1002355
  year: 2011
  ident: bib13
  article-title: Novel anti-bacterial activities of β-defensin 1 in human platelets: suppression of pathogen growth and signaling of neutrophil extracellular trap formation
  publication-title: PLoS Pathog
– volume: 7
  start-page: e1002337
  year: 2011
  ident: bib26
  article-title: IFITM3 inhibits influenza A virus infection by preventing cytosolic entry
  publication-title: PLoS Pathog
– volume: 48
  start-page: 222
  year: 1993
  end-page: 229
  ident: bib56
  article-title: High levels of interferon alpha in the sera of children with dengue virus infection
  publication-title: Am J Trop Med Hyg
– volume: 385
  start-page: 453
  year: 2015
  end-page: 465
  ident: bib47
  article-title: Dengue
  publication-title: Lancet
– volume: 2
  start-page: 91
  year: 2013
  end-page: 101
  ident: bib58
  article-title: Effects of human immunodeficiency virus on the erythrocyte and megakaryocyte lineages
  publication-title: World J Virol
– volume: 8
  start-page: e33
  year: 2011
  end-page: e38
  ident: bib1
  article-title: Platelets in dengue infection
  publication-title: Drug Discov Today Dis Mech
– volume: 74
  start-page: 4957
  year: 2000
  end-page: 4966
  ident: bib23
  article-title: Modulation of dengue virus infection in human cells by alpha, beta, and gamma interferons
  publication-title: J Virol
– volume: 200
  start-page: 295
  year: 2018
  end-page: 304
  ident: bib18
  article-title: Granzyme A in human platelets regulates the synthesis of proinflammatory cytokines by monocytes in Aging
  publication-title: J Immunol
– volume: 8
  start-page: 249
  year: 1995
  end-page: 270
  ident: bib31
  article-title: Mechanisms of dengue virus-induced bone marrow suppression
  publication-title: Baillieres Clin Haematol
– volume: 12
  start-page: 426
  year: 2014
  end-page: 437
  ident: bib41
  article-title: Platelets: at the nexus of antimicrobial defence
  publication-title: Nat Rev Microbiol
– reference: Vieira-de-Abreu A, Rondina MT, Weyrich AS, Zimmerman GA,. Inflammation. In: Michelson AD, ed. Platelets. New York, NY: Elsevier; 2012:733-766.
– volume: 363
  start-page: 484
  year: 2010
  end-page: 487
  ident: bib2
  article-title: Response to dengue fever—the good, the bad, and the ugly?
  publication-title: N Engl J Med
– volume: 7
  start-page: e52902
  year: 2012
  ident: bib30
  article-title: Multiploid CD61+ cells are the pre-dominant cell lineage infected during acute dengue virus infection in bone marrow
  publication-title: PLoS One
– volume: 1
  start-page: 1773
  year: 2017
  end-page: 1785
  ident: bib40
  article-title: Mature murine megakaryocytes present antigen-MHC class I molecules to T cells and transfer them to platelets
  publication-title: Blood Adv
– volume: 40
  start-page: 250
  year: 2012
  end-page: 259.e4
  ident: bib32
  article-title: Infection of bone marrow cells by dengue virus in vivo
  publication-title: Exp Hematol
– volume: 123
  start-page: 2854
  year: 2014
  end-page: 2863
  ident: bib28
  article-title: Influenza virus H1N1 activates platelets through FcγRIIA signaling and thrombin generation
  publication-title: Blood
– volume: 38
  start-page: 801
  year: 2018
  end-page: 815
  ident: bib21
  article-title: Endogenous LINE-1 (long interspersed nuclear element-1) reverse transcriptase activity in platelets controls translational events through RNA-DNA hybrids
  publication-title: Arterioscler Thromb Vasc Biol
– volume: 14
  start-page: 1082
  year: 2016
  end-page: 1094
  ident: bib17
  article-title: Non-genomic activities of retinoic acid receptor alpha control actin cytoskeletal events in human platelets
  publication-title: J Thromb Haemost
– volume: 189
  start-page: 916
  year: 2012
  end-page: 923
  ident: bib39
  article-title: Platelets present antigen in the context of MHC class I
  publication-title: J Immunol
– volume: 139
  start-page: 1243
  year: 2009
  end-page: 1254
  ident: bib24
  article-title: The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus
  publication-title: Cell
– volume: 23
  start-page: 236
  year: 2016
  end-page: 242
  ident: bib29
  article-title: Standardization of hemagglutination inhibition assay for influenza serology allows for high reproducibility between laboratories
  publication-title: Clin Vaccine Immunol
– volume: 203
  start-page: 2433
  year: 2006
  end-page: 2440
  ident: bib15
  article-title: Signal-dependent splicing of tissue factor pre-mRNA modulates the thrombogenicity of human platelets
  publication-title: J Exp Med
– volume: 8
  start-page: 273
  year: 2010
  end-page: 276
  ident: bib5
  article-title: The dengue threat to the United States
  publication-title: Biosecur Bioterror
– volume: 9
  start-page: E223
  year: 2017
  ident: bib45
  article-title: Influenza virus infection, interferon response, viral counter-response, and apoptosis
  publication-title: Viruses
– volume: 134
  start-page: 27
  year: 2010
  end-page: 35
  ident: bib59
  article-title: Autopsy findings in eight patients with fatal H1N1 influenza
  publication-title: Am J Clin Pathol
– volume: 9
  start-page: 2477
  year: 2011
  end-page: 2485
  ident: bib49
  article-title: Expression and functionality of type I interferon receptor in the megakaryocytic lineage
  publication-title: J Thromb Haemost
– volume: 60
  start-page: 196
  year: 2014
  end-page: 199
  ident: bib36
  article-title: A strong interferon response correlates with a milder dengue clinical condition
  publication-title: J Clin Virol
– volume: 109
  start-page: 9569
  year: 2012
  end-page: 9574
  ident: bib38
  article-title: Identification of the platelet-derived chemokine CXCL4/PF-4 as a broad-spectrum HIV-1 inhibitor
  publication-title: Proc Natl Acad Sci U S A
– volume: 193
  start-page: 1864
  year: 2014
  end-page: 1872
  ident: bib54
  article-title: Platelet activation and apoptosis modulate monocyte inflammatory responses in dengue
  publication-title: J Immunol
– volume: 126
  start-page: 378
  year: 2015
  end-page: 385
  ident: bib34
  article-title: Dengue virus binding and replication by platelets
  publication-title: Blood
– volume: 7
  start-page: 41697
  year: 2017
  ident: bib52
  article-title: Platelet activation determines the severity of thrombocytopenia in dengue infection
  publication-title: Sci Rep
– volume: 40
  start-page: 250
  issue: 3
  year: 2012
  ident: 2020021109302182300_B32
  article-title: Infection of bone marrow cells by dengue virus in vivo
  publication-title: Exp Hematol
  doi: 10.1016/j.exphem.2011.11.011
– volume: 544
  start-page: 105
  issue: 7648
  year: 2017
  ident: 2020021109302182300_B62
  article-title: The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors
  publication-title: Nature
  doi: 10.1038/nature21706
– volume: 123
  start-page: 2854
  issue: 18
  year: 2014
  ident: 2020021109302182300_B28
  article-title: Influenza virus H1N1 activates platelets through FcγRIIA signaling and thrombin generation
  publication-title: Blood
  doi: 10.1182/blood-2013-07-515536
– volume: 23
  start-page: 236
  issue: 3
  year: 2016
  ident: 2020021109302182300_B29
  article-title: Standardization of hemagglutination inhibition assay for influenza serology allows for high reproducibility between laboratories
  publication-title: Clin Vaccine Immunol
  doi: 10.1128/CVI.00613-15
– volume: 127
  start-page: 1714
  issue: 5
  year: 2017
  ident: 2020021109302182300_B63
  article-title: Megakaryocytes compensate for Kit insufficiency in murine arthritis
  publication-title: J Clin Invest
  doi: 10.1172/JCI84598
– volume: 111
  start-page: 378
  issue: 6
  year: 2016
  ident: 2020021109302182300_B35
  article-title: Primary dengue haemorrhagic fever in patients from northeast of Brazil is associated with high levels of interferon-β during acute phase
  publication-title: Mem Inst Oswaldo Cruz
  doi: 10.1590/0074-02760150453
– volume: 17
  start-page: 653
  issue: 5
  year: 2015
  ident: 2020021109302182300_B65
  article-title: Blockade of interferon beta, but not interferon alpha, signaling controls persistent viral infection
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2015.04.005
– volume: 112
  start-page: 1506
  issue: 11
  year: 2013
  ident: 2020021109302182300_B11
  article-title: Platelets as cellular effectors of inflammation in vascular diseases
  publication-title: Circ Res
  doi: 10.1161/CIRCRESAHA.113.300512
– volume: 134
  start-page: 27
  issue: 1
  year: 2010
  ident: 2020021109302182300_B59
  article-title: Autopsy findings in eight patients with fatal H1N1 influenza
  publication-title: Am J Clin Pathol
  doi: 10.1309/AJCP35KOZSAVNQZW
– volume: 122
  start-page: 3405
  issue: 20
  year: 2013
  ident: 2020021109302182300_B16
  article-title: Platelets mediate increased endothelium permeability in dengue through NLRP3-inflammasome activation
  publication-title: Blood
  doi: 10.1182/blood-2013-05-504449
– volume: 207
  start-page: 86
  issue: 2
  year: 2011
  ident: 2020021109302182300_B60
  article-title: Pathology of the swine-origin influenza A (H1N1) flu
  publication-title: Pathol Res Pract
  doi: 10.1016/j.prp.2010.11.003
– volume: 60
  start-page: 196
  issue: 3
  year: 2014
  ident: 2020021109302182300_B36
  article-title: A strong interferon response correlates with a milder dengue clinical condition
  publication-title: J Clin Virol
  doi: 10.1016/j.jcv.2014.04.002
– volume: 9
  start-page: E223
  issue: 8
  year: 2017
  ident: 2020021109302182300_B45
  article-title: Influenza virus infection, interferon response, viral counter-response, and apoptosis
  publication-title: Viruses
  doi: 10.3390/v9080223
– volume: 97
  start-page: 10
  year: 2017
  ident: 2020021109302182300_B46
  article-title: Characterization of type I interferon responses in dengue and severe dengue in children in Paraguay
  publication-title: J Clin Virol
  doi: 10.1016/j.jcv.2017.10.010
– volume: 141
  start-page: 1490
  issue: 6
  year: 2012
  ident: 2020021109302182300_B27
  article-title: In vivo platelet activation in critically ill patients with primary 2009 influenza A(H1N1)
  publication-title: Chest
  doi: 10.1378/chest.11-2860
– start-page: 733
  volume-title: Platelets
  year: 2012
  ident: 2020021109302182300_B6
  article-title: Inflammation
– volume: 368
  start-page: 1888
  issue: 20
  year: 2013
  ident: 2020021109302182300_B4
  article-title: Human infection with a novel avian-origin influenza A (H7N9) virus
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa1304459
– volume: 13
  start-page: e1006385
  issue: 5
  year: 2017
  ident: 2020021109302182300_B44
  article-title: Platelet proteome reveals novel pathways of platelet activation and platelet-mediated immunoregulation in dengue
  publication-title: PLoS Pathog
  doi: 10.1371/journal.ppat.1006385
– volume: 87
  start-page: 11648
  issue: 21
  year: 2013
  ident: 2020021109302182300_B33
  article-title: Inhibition of megakaryocyte development in the bone marrow underlies dengue virus-induced thrombocytopenia in humanized mice
  publication-title: J Virol
  doi: 10.1128/JVI.01156-13
– volume: 74
  start-page: 4957
  issue: 11
  year: 2000
  ident: 2020021109302182300_B23
  article-title: Modulation of dengue virus infection in human cells by alpha, beta, and gamma interferons
  publication-title: J Virol
  doi: 10.1128/JVI.74.11.4957-4966.2000
– volume: 139
  start-page: 1243
  issue: 7
  year: 2009
  ident: 2020021109302182300_B24
  article-title: The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus
  publication-title: Cell
  doi: 10.1016/j.cell.2009.12.017
– volume: 270
  start-page: 1811
  issue: 5243
  year: 1995
  ident: 2020021109302182300_B43
  article-title: Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells
  publication-title: Science
  doi: 10.1126/science.270.5243.1811
– volume: 127
  start-page: 1743
  issue: 14
  year: 2016
  ident: 2020021109302182300_B20
  article-title: Dicer1-mediated miRNA processing shapes the mRNA profile and function of murine platelets
  publication-title: Blood
  doi: 10.1182/blood-2015-07-661371
– volume: 193
  start-page: 1864
  issue: 4
  year: 2014
  ident: 2020021109302182300_B54
  article-title: Platelet activation and apoptosis modulate monocyte inflammatory responses in dengue
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1400091
– volume: 78
  start-page: 2062
  issue: 8
  year: 1991
  ident: 2020021109302182300_B48
  article-title: Identification and characterization of a functional receptor for interferon-gamma on a megakaryocytic cell line
  publication-title: Blood
  doi: 10.1182/blood.V78.8.2062.2062
– volume: 7
  start-page: 41697
  issue: 1
  year: 2017
  ident: 2020021109302182300_B52
  article-title: Platelet activation determines the severity of thrombocytopenia in dengue infection
  publication-title: Sci Rep
  doi: 10.1038/srep41697
– volume: 88
  start-page: 446
  issue: 3
  year: 2013
  ident: 2020021109302182300_B55
  article-title: Determination of viremia and concentration of circulating nonstructural protein 1 in patients infected with dengue virus in Mexico
  publication-title: Am J Trop Med Hyg
  doi: 10.4269/ajtmh.12-0023
– volume: 171
  start-page: 1368
  issue: 6
  year: 2017
  ident: 2020021109302182300_B12
  article-title: Migrating platelets are mechano-scavengers that collect and bundle bacteria
  publication-title: Cell
  doi: 10.1016/j.cell.2017.11.001
– volume: 38
  start-page: 801
  issue: 4
  year: 2018
  ident: 2020021109302182300_B21
  article-title: Endogenous LINE-1 (long interspersed nuclear element-1) reverse transcriptase activity in platelets controls translational events through RNA-DNA hybrids
  publication-title: Arterioscler Thromb Vasc Biol
  doi: 10.1161/ATVBAHA.117.310552
– volume: 25
  start-page: 489
  issue: 9
  year: 2004
  ident: 2020021109302182300_B7
  article-title: Platelets: signaling cells in the immune continuum
  publication-title: Trends Immunol
  doi: 10.1016/j.it.2004.07.003
– volume: 11
  start-page: 951
  issue: 5
  year: 2013
  ident: 2020021109302182300_B53
  article-title: Dengue induces platelet activation, mitochondrial dysfunction and cell death through mechanisms that involve DC-SIGN and caspases
  publication-title: J Thromb Haemost
  doi: 10.1111/jth.12178
– volume: 52
  start-page: e14
  issue: 2
  year: 2011
  ident: 2020021109302182300_B61
  article-title: Pandemic H1N1 influenza infection and vascular thrombosis
  publication-title: Clin Infect Dis
  doi: 10.1093/cid/ciq125
– volume: 126
  start-page: 378
  issue: 3
  year: 2015
  ident: 2020021109302182300_B34
  article-title: Dengue virus binding and replication by platelets
  publication-title: Blood
  doi: 10.1182/blood-2014-09-598029
– volume: 363
  start-page: 484
  issue: 5
  year: 2010
  ident: 2020021109302182300_B2
  article-title: Response to dengue fever—the good, the bad, and the ugly?
  publication-title: N Engl J Med
  doi: 10.1056/NEJMcibr1005904
– volume: 2
  start-page: 91
  issue: 2
  year: 2013
  ident: 2020021109302182300_B58
  article-title: Effects of human immunodeficiency virus on the erythrocyte and megakaryocyte lineages
  publication-title: World J Virol
  doi: 10.5501/wjv.v2.i2.91
– volume: 189
  start-page: 916
  issue: 2
  year: 2012
  ident: 2020021109302182300_B39
  article-title: Platelets present antigen in the context of MHC class I
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1200580
– volume: 385
  start-page: 453
  issue: 9966
  year: 2015
  ident: 2020021109302182300_B47
  article-title: Dengue
  publication-title: Lancet
  doi: 10.1016/S0140-6736(14)60572-9
– volume: 8
  start-page: 273
  issue: 3
  year: 2010
  ident: 2020021109302182300_B5
  article-title: The dengue threat to the United States
  publication-title: Biosecur Bioterror
  doi: 10.1089/bsp.2010.0032
– volume: 212
  start-page: 702
  issue: 5
  year: 2015
  ident: 2020021109302182300_B14
  article-title: Robust and balanced immune responses to all 4 dengue virus serotypes following administration of a single dose of a live attenuated tetravalent dengue vaccine to healthy, flavivirus-naive adults
  publication-title: J Infect Dis
  doi: 10.1093/infdis/jiv082
– volume: 11
  start-page: 264
  issue: 4
  year: 2011
  ident: 2020021109302182300_B9
  article-title: Platelets and the immune continuum
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri2956
– volume: 203
  start-page: 2433
  issue: 11
  year: 2006
  ident: 2020021109302182300_B15
  article-title: Signal-dependent splicing of tissue factor pre-mRNA modulates the thrombogenicity of human platelets
  publication-title: J Exp Med
  doi: 10.1084/jem.20061302
– volume: 14
  start-page: 1082
  issue: 5
  year: 2016
  ident: 2020021109302182300_B17
  article-title: Non-genomic activities of retinoic acid receptor alpha control actin cytoskeletal events in human platelets
  publication-title: J Thromb Haemost
  doi: 10.1111/jth.13281
– volume: 7
  start-page: e1002355
  issue: 11
  year: 2011
  ident: 2020021109302182300_B13
  article-title: Novel anti-bacterial activities of β-defensin 1 in human platelets: suppression of pathogen growth and signaling of neutrophil extracellular trap formation
  publication-title: PLoS Pathog
  doi: 10.1371/journal.ppat.1002355
– volume: 7
  start-page: e1002337
  issue: 10
  year: 2011
  ident: 2020021109302182300_B26
  article-title: IFITM3 inhibits influenza A virus infection by preventing cytosolic entry
  publication-title: PLoS Pathog
  doi: 10.1371/journal.ppat.1002337
– volume: 1
  start-page: 1773
  issue: 20
  year: 2017
  ident: 2020021109302182300_B40
  article-title: Mature murine megakaryocytes present antigen-MHC class I molecules to T cells and transfer them to platelets
  publication-title: Blood Adv
  doi: 10.1182/bloodadvances.2017007021
– volume: 484
  start-page: 519
  issue: 7395
  year: 2012
  ident: 2020021109302182300_B25
  article-title: IFITM3 restricts the morbidity and mortality associated with influenza
  publication-title: Nature
  doi: 10.1038/nature10921
– volume: 8
  start-page: 249
  issue: 1
  year: 1995
  ident: 2020021109302182300_B31
  article-title: Mechanisms of dengue virus-induced bone marrow suppression
  publication-title: Baillieres Clin Haematol
  doi: 10.1016/S0950-3536(05)80240-9
– volume: 164
  start-page: 349
  issue: 3
  year: 2016
  ident: 2020021109302182300_B64
  article-title: Alpha and Beta Type 1 Interferon Signaling: Passage for Diverse Biologic Outcomes
  publication-title: Cell
  doi: 10.1016/j.cell.2015.12.027
– volume: 4
  start-page: 1418
  issue: 1
  year: 2013
  ident: 2020021109302182300_B37
  article-title: Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with severe influenza in Chinese individuals
  publication-title: Nat Commun
  doi: 10.1038/ncomms2433
– volume: 109
  start-page: 9569
  issue: 24
  year: 2012
  ident: 2020021109302182300_B38
  article-title: Identification of the platelet-derived chemokine CXCL4/PF-4 as a broad-spectrum HIV-1 inhibitor
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1207314109
– volume: 48
  start-page: 222
  issue: 2
  year: 1993
  ident: 2020021109302182300_B56
  article-title: High levels of interferon alpha in the sera of children with dengue virus infection
  publication-title: Am J Trop Med Hyg
  doi: 10.4269/ajtmh.1993.48.222
– volume: 3
  start-page: e2985
  issue: 8
  year: 2008
  ident: 2020021109302182300_B3
  article-title: Clinical characteristics of 26 human cases of highly pathogenic avian influenza A (H5N1) virus infection in China
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0002985
– volume: 10
  start-page: 48
  issue: 1
  year: 2013
  ident: 2020021109302182300_B42
  article-title: Platelet activation suppresses HIV-1 infection of T cells
  publication-title: Retrovirology
  doi: 10.1186/1742-4690-10-48
– volume: 9
  start-page: 2477
  issue: 12
  year: 2011
  ident: 2020021109302182300_B49
  article-title: Expression and functionality of type I interferon receptor in the megakaryocytic lineage
  publication-title: J Thromb Haemost
  doi: 10.1111/j.1538-7836.2011.04530.x
– volume: 7
  start-page: e52902
  issue: 12
  year: 2012
  ident: 2020021109302182300_B30
  article-title: Multiploid CD61+ cells are the pre-dominant cell lineage infected during acute dengue virus infection in bone marrow
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0052902
– volume: 9
  start-page: e83386
  issue: 4
  year: 2014
  ident: 2020021109302182300_B51
  article-title: The pathology of severe dengue in multiple organs of human fatal cases: histopathology, ultrastructure and virus replication
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0083386
– volume: 8
  start-page: e2858
  issue: 6
  year: 2014
  ident: 2020021109302182300_B57
  article-title: The role of platelets in the pathogenesis of viral hemorrhagic fevers
  publication-title: PLoS Negl Trop Dis
  doi: 10.1371/journal.pntd.0002858
– volume: 37
  start-page: 1819
  issue: 10
  year: 2017
  ident: 2020021109302182300_B19
  article-title: Clots are potent triggers of inflammatory cell gene expression: indications for timely fibrinolysis
  publication-title: Arterioscler Thromb Vasc Biol
  doi: 10.1161/ATVBAHA.117.309794
– volume: 25
  start-page: 402
  issue: 4
  year: 2001
  ident: 2020021109302182300_B22
  article-title: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method
  publication-title: Methods
  doi: 10.1006/meth.2001.1262
– volume: 449
  start-page: 819
  issue: 7164
  year: 2007
  ident: 2020021109302182300_B10
  article-title: Recognition of microorganisms and activation of the immune response
  publication-title: Nature
  doi: 10.1038/nature06246
– volume: 80
  start-page: 841
  issue: 5
  year: 2009
  ident: 2020021109302182300_B50
  article-title: Increased phagocytosis of platelets from patients with secondary dengue virus infection by human macrophages
  publication-title: Am J Trop Med Hyg
  doi: 10.4269/ajtmh.2009.80.841
– volume: 34
  start-page: 5
  issue: 1
  year: 2012
  ident: 2020021109302182300_B8
  article-title: Platelets: versatile effector cells in hemostasis, inflammation, and the immune continuum
  publication-title: Semin Immunopathol
  doi: 10.1007/s00281-011-0286-4
– volume: 200
  start-page: 295
  issue: 1
  year: 2018
  ident: 2020021109302182300_B18
  article-title: Granzyme A in human platelets regulates the synthesis of proinflammatory cytokines by monocytes in Aging
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1700885
– volume: 12
  start-page: 426
  issue: 6
  year: 2014
  ident: 2020021109302182300_B41
  article-title: Platelets: at the nexus of antimicrobial defence
  publication-title: Nat Rev Microbiol
  doi: 10.1038/nrmicro3269
– volume: 8
  start-page: e33
  issue: 1-2
  year: 2011
  ident: 2020021109302182300_B1
  article-title: Platelets in dengue infection
  publication-title: Drug Discov Today Dis Mech
  doi: 10.1016/j.ddmec.2011.09.001
– reference: 31072959 - Blood. 2019 May 9;133(19):2001-2002. doi: 10.1182/blood-2019-02-900787
– reference: 31257735 - J Thromb Haemost. 2019 Jul;17(7):1013. doi: 10.1111/jth.14490
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Snippet Evolving evidence indicates that platelets and megakaryocytes (MKs) have unexpected activities in inflammation and infection; whether viral infections...
Publisher's Note: There is a Blood Commentary on this article in this issue. Viral infections upregulate IFITM3 in human platelets and MKs, triggering rapid...
SourceID pubmedcentral
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StartPage 2013
SubjectTerms Dengue - immunology
Dengue Vaccines - immunology
Humans
Immunity, Innate - immunology
Megakaryocytes - immunology
Membrane Proteins - immunology
Plenary Paper
RNA-Binding Proteins - immunology
Title Human megakaryocytes possess intrinsic antiviral immunity through regulated induction of IFITM3
URI https://dx.doi.org/10.1182/blood-2018-09-873984
https://www.ncbi.nlm.nih.gov/pubmed/30723081
https://www.proquest.com/docview/2211325602
https://pubmed.ncbi.nlm.nih.gov/PMC6509546
Volume 133
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