Periodontitis is associated with disease severity and anti-double stranded DNA antibody and interferon-gamma levels in patients with systemic lupus erythematosus
لتحليل توافق شدة التهاب اللثة مع نشاط المرض، والأجسام المضادة لـلحمض النووي الريبي المختزل مزدوج الضفيرة والمضاد الضوئي المناعي في مرضى الذئبة الحمامية المجموعية. في هذه الدراسة الرصدية المستعرضة، اخترنا ٦١ مريضا يعانون من مرض الذئبة الحمامية المجموعية (سن ١٨-٥٥ سنة) من مستشفى إندونيسي في مالانج. وأ...
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| Published in | Journal of Taibah University Medical Sciences Vol. 14; no. 6; pp. 560 - 565 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Saudi Arabia
Elsevier Ltd
01.12.2019
Taibah University Elsevier |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1658-3612 1658-3612 |
| DOI | 10.1016/j.jtumed.2019.09.005 |
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| Abstract | لتحليل توافق شدة التهاب اللثة مع نشاط المرض، والأجسام المضادة لـلحمض النووي الريبي المختزل مزدوج الضفيرة والمضاد الضوئي المناعي في مرضى الذئبة الحمامية المجموعية.
في هذه الدراسة الرصدية المستعرضة، اخترنا ٦١ مريضا يعانون من مرض الذئبة الحمامية المجموعية (سن ١٨-٥٥ سنة) من مستشفى إندونيسي في مالانج. وأجري الفحص السريري والاختبارات المعملية لتقييم نشاط المرض. وتم قياس شدة مرض الذئبة الحمامية المجموعية باستخدام مؤشر نشاطها، وقيست شدة التهاب اللثة باستخدام معايير مؤشر اللثة. كما تم تحديد مستويات الأجسام المضادة لـلحمض النووي الريبي المختزل مزدوج الضفيرة والمضاد الضوئي المناعي باستخدام مقايسة الممتز المناعي المرتبط بالإنزيم (إلايسا). وتم قياس الكثافة البصرية على قارئ طبق آلي لـ ٤٥٠ نانومتر.
كان متوسط عمر المصابين بمرض الذئبة الحمامية المجموعية ٢٩ سنة وكانت مدة المرض ٢.٨ سنة. ووجدنا أن ٥٤/٦١ (٨٨.٥٪) من المصابين بمرض الذئبة الحمامية المجموعية لديهم التهاب اللثة، بناءً على تقييم مؤشر اللثة. وكان لدى مرضى الذئبة الحمامية المجموعية مظاهر سريرية أخرى مثل التهاب الكلية الذئبي والتهاب الأوعية الدموية والتهاب المفاصل وأعراض الجلد والأغشية المخاطية والتعب والحمى ونقص الكريات البيضاء. تم تقييم شدة مرض الذئبة الحمامية المجموعية باستخدام مؤشر نشاط الذئبة الحمامية المجموعية بنتيجة متوسطة ١٧.٧ +/- ١٢.٧، ومتوسط نتيجة الأجسام المضادة لـلحمض النووي الريبي المختزل مزدوج الضفيرة ومستوى المضاد الضوئي المناعي ١٢٢.٦ +/- ٨١ وحدة / مل، و١٤.٦+/- ١١.١٧ بيكوجرام / مل. كان هناك توافق إيجابي كبير ذو قيمة إحصائية بين درجة التهاب اللثة ونتيجة مؤشر نشاط الذئبة الحمامية المجموعية (معامل التوافق: ٠.٩٢٧) ومضادات الحمض النووي الريبي المختزل مزدوج الضفيرة (معامل التوافق: ٠.٩٤٧) ومضاد ضوئي مناعي (معامل التوافق: ٠.٩٥١).
أظهرت دراستنا أن التهاب اللثة مرتبط بنشاط مرض الذئبة الحمامية المجموعية، والمؤشر الحيوي للشيخوخة المناعية. علاوة على ذلك، يمكن أن يكون المؤشر الحيوي للشيخوخة أداة يُعتمد عليها في توقع حالات التهابات اللثة وأساليب تطورها، واختيار أفضل علاج لالتهاب اللثة في مرضى الذئبة الحمامية المجموعية.
To analyse the correlation between periodontitis severity and disease activity, anti-double stranded DNA (anti-dsDNA) antibody, and interferon-gamma (IFN-γ) levels in patients with systemic lupus erythematous (SLE).
We selected 61 patients with SLE (age 18–55 years) selected from a hospital in Malang, Indonesia. Clinical examination and laboratory tests were performed to assess disease activity. The severity of SLE was measured using the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), while periodontitis severity was measured according to the Periodontal Index (PI) criteria. Levels of anti-dsDNA and IFN-γ were determined using an enzyme-linked immunosorbent assay. Optical density at 450 nm was measured using an automated plate reader.
The mean age of the subjects with SLE was 29 years, and mean disease duration was 2.8 years. Fifty-four of 61 (88.53%) subjects with SLE had periodontitis according to the PI. SLE subjects exhibited other clinical manifestations such as lupus nephritis, vasculitis, arthritis, mucocutaneous manifestation, fatigue, fever, and/or leukopenia. SLE severity was assessed according to the average SLEDAI score (17.70 ± 12.70), and average anti-dsDNA (122.6 ± 81.01 U/mL), and IFN-γ (14.64 ± 11.17 pg/mL) levels. There was a significantly positive correlation between periodontitis score and SLEDAI score (r = 0.927; p ≤ 0.0001), anti-dsDNA antibody (r = 0.948; p ≤ 0.0001), and IFN-γ (r = 0.951; p ≤ 0.0001) levels.
Results of the present study demonstrated that periodontitis was associated with SLE disease activity, and was a biomarker of immune aging. Furthermore, this biomarker could be a reliable predictor of periodontal condition and prognosis of periodontitis and can also help in selecting the most appropriate treatment strategy for periodontitis in patients with SLE. |
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| AbstractList | لتحليل توافق شدة التهاب اللثة مع نشاط المرض، والأجسام المضادة لـلحمض النووي الريبي المختزل مزدوج الضفيرة والمضاد الضوئي المناعي في مرضى الذئبة الحمامية المجموعية.
في هذه الدراسة الرصدية المستعرضة، اخترنا ٦١ مريضا يعانون من مرض الذئبة الحمامية المجموعية (سن ١٨-٥٥ سنة) من مستشفى إندونيسي في مالانج. وأجري الفحص السريري والاختبارات المعملية لتقييم نشاط المرض. وتم قياس شدة مرض الذئبة الحمامية المجموعية باستخدام مؤشر نشاطها، وقيست شدة التهاب اللثة باستخدام معايير مؤشر اللثة. كما تم تحديد مستويات الأجسام المضادة لـلحمض النووي الريبي المختزل مزدوج الضفيرة والمضاد الضوئي المناعي باستخدام مقايسة الممتز المناعي المرتبط بالإنزيم (إلايسا). وتم قياس الكثافة البصرية على قارئ طبق آلي لـ ٤٥٠ نانومتر.
كان متوسط عمر المصابين بمرض الذئبة الحمامية المجموعية ٢٩ سنة وكانت مدة المرض ٢.٨ سنة. ووجدنا أن ٥٤/٦١ (٨٨.٥٪) من المصابين بمرض الذئبة الحمامية المجموعية لديهم التهاب اللثة، بناءً على تقييم مؤشر اللثة. وكان لدى مرضى الذئبة الحمامية المجموعية مظاهر سريرية أخرى مثل التهاب الكلية الذئبي والتهاب الأوعية الدموية والتهاب المفاصل وأعراض الجلد والأغشية المخاطية والتعب والحمى ونقص الكريات البيضاء. تم تقييم شدة مرض الذئبة الحمامية المجموعية باستخدام مؤشر نشاط الذئبة الحمامية المجموعية بنتيجة متوسطة ١٧.٧ +/- ١٢.٧، ومتوسط نتيجة الأجسام المضادة لـلحمض النووي الريبي المختزل مزدوج الضفيرة ومستوى المضاد الضوئي المناعي ١٢٢.٦ +/- ٨١ وحدة / مل، و١٤.٦+/- ١١.١٧ بيكوجرام / مل. كان هناك توافق إيجابي كبير ذو قيمة إحصائية بين درجة التهاب اللثة ونتيجة مؤشر نشاط الذئبة الحمامية المجموعية (معامل التوافق: ٠.٩٢٧) ومضادات الحمض النووي الريبي المختزل مزدوج الضفيرة (معامل التوافق: ٠.٩٤٧) ومضاد ضوئي مناعي (معامل التوافق: ٠.٩٥١).
أظهرت دراستنا أن التهاب اللثة مرتبط بنشاط مرض الذئبة الحمامية المجموعية، والمؤشر الحيوي للشيخوخة المناعية. علاوة على ذلك، يمكن أن يكون المؤشر الحيوي للشيخوخة أداة يُعتمد عليها في توقع حالات التهابات اللثة وأساليب تطورها، واختيار أفضل علاج لالتهاب اللثة في مرضى الذئبة الحمامية المجموعية.
To analyse the correlation between periodontitis severity and disease activity, anti-double stranded DNA (anti-dsDNA) antibody, and interferon-gamma (IFN-γ) levels in patients with systemic lupus erythematous (SLE).
We selected 61 patients with SLE (age 18–55 years) selected from a hospital in Malang, Indonesia. Clinical examination and laboratory tests were performed to assess disease activity. The severity of SLE was measured using the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), while periodontitis severity was measured according to the Periodontal Index (PI) criteria. Levels of anti-dsDNA and IFN-γ were determined using an enzyme-linked immunosorbent assay. Optical density at 450 nm was measured using an automated plate reader.
The mean age of the subjects with SLE was 29 years, and mean disease duration was 2.8 years. Fifty-four of 61 (88.53%) subjects with SLE had periodontitis according to the PI. SLE subjects exhibited other clinical manifestations such as lupus nephritis, vasculitis, arthritis, mucocutaneous manifestation, fatigue, fever, and/or leukopenia. SLE severity was assessed according to the average SLEDAI score (17.70 ± 12.70), and average anti-dsDNA (122.6 ± 81.01 U/mL), and IFN-γ (14.64 ± 11.17 pg/mL) levels. There was a significantly positive correlation between periodontitis score and SLEDAI score (r = 0.927; p ≤ 0.0001), anti-dsDNA antibody (r = 0.948; p ≤ 0.0001), and IFN-γ (r = 0.951; p ≤ 0.0001) levels.
Results of the present study demonstrated that periodontitis was associated with SLE disease activity, and was a biomarker of immune aging. Furthermore, this biomarker could be a reliable predictor of periodontal condition and prognosis of periodontitis and can also help in selecting the most appropriate treatment strategy for periodontitis in patients with SLE. الملخص: أهداف البحث: لتحليل توافق شدة التهاب اللثة مع نشاط المرض، والأجسام المضادة لـلحمض النووي الريبي المختزل مزدوج الضفيرة والمضاد الضوئي المناعي في مرضى الذئبة الحمامية المجموعية. طرق البحث: في هذه الدراسة الرصدية المستعرضة، اخترنا ٦١ مريضا يعانون من مرض الذئبة الحمامية المجموعية (سن ١٨-٥٥ سنة) من مستشفى إندونيسي في مالانج. وأجري الفحص السريري والاختبارات المعملية لتقييم نشاط المرض. وتم قياس شدة مرض الذئبة الحمامية المجموعية باستخدام مؤشر نشاطها، وقيست شدة التهاب اللثة باستخدام معايير مؤشر اللثة. كما تم تحديد مستويات الأجسام المضادة لـلحمض النووي الريبي المختزل مزدوج الضفيرة والمضاد الضوئي المناعي باستخدام مقايسة الممتز المناعي المرتبط بالإنزيم (إلايسا). وتم قياس الكثافة البصرية على قارئ طبق آلي لـ ٤٥٠ نانومتر. النتائج: كان متوسط عمر المصابين بمرض الذئبة الحمامية المجموعية ٢٩ سنة وكانت مدة المرض ٢.٨ سنة. ووجدنا أن ٥٤/٦١ (٨٨.٥٪) من المصابين بمرض الذئبة الحمامية المجموعية لديهم التهاب اللثة، بناءً على تقييم مؤشر اللثة. وكان لدى مرضى الذئبة الحمامية المجموعية مظاهر سريرية أخرى مثل التهاب الكلية الذئبي والتهاب الأوعية الدموية والتهاب المفاصل وأعراض الجلد والأغشية المخاطية والتعب والحمى ونقص الكريات البيضاء. تم تقييم شدة مرض الذئبة الحمامية المجموعية باستخدام مؤشر نشاط الذئبة الحمامية المجموعية بنتيجة متوسطة ١٧.٧ +/- ١٢.٧، ومتوسط نتيجة الأجسام المضادة لـلحمض النووي الريبي المختزل مزدوج الضفيرة ومستوى المضاد الضوئي المناعي ١٢٢.٦ +/- ٨١ وحدة / مل، و١٤.٦+/- ١١.١٧ بيكوجرام / مل. كان هناك توافق إيجابي كبير ذو قيمة إحصائية بين درجة التهاب اللثة ونتيجة مؤشر نشاط الذئبة الحمامية المجموعية (معامل التوافق: ٠.٩٢٧) ومضادات الحمض النووي الريبي المختزل مزدوج الضفيرة (معامل التوافق: ٠.٩٤٧) ومضاد ضوئي مناعي (معامل التوافق: ٠.٩٥١). الاستنتاجات: أظهرت دراستنا أن التهاب اللثة مرتبط بنشاط مرض الذئبة الحمامية المجموعية، والمؤشر الحيوي للشيخوخة المناعية. علاوة على ذلك، يمكن أن يكون المؤشر الحيوي للشيخوخة أداة يُعتمد عليها في توقع حالات التهابات اللثة وأساليب تطورها، واختيار أفضل علاج لالتهاب اللثة في مرضى الذئبة الحمامية المجموعية. Abstract: Objectives: To analyse the correlation between periodontitis severity and disease activity, anti-double stranded DNA (anti-dsDNA) antibody, and interferon-gamma (IFN-γ) levels in patients with systemic lupus erythematous (SLE). Methods: We selected 61 patients with SLE (age 18–55 years) selected from a hospital in Malang, Indonesia. Clinical examination and laboratory tests were performed to assess disease activity. The severity of SLE was measured using the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), while periodontitis severity was measured according to the Periodontal Index (PI) criteria. Levels of anti-dsDNA and IFN-γ were determined using an enzyme-linked immunosorbent assay. Optical density at 450 nm was measured using an automated plate reader. Results: The mean age of the subjects with SLE was 29 years, and mean disease duration was 2.8 years. Fifty-four of 61 (88.53%) subjects with SLE had periodontitis according to the PI. SLE subjects exhibited other clinical manifestations such as lupus nephritis, vasculitis, arthritis, mucocutaneous manifestation, fatigue, fever, and/or leukopenia. SLE severity was assessed according to the average SLEDAI score (17.70 ± 12.70), and average anti-dsDNA (122.6 ± 81.01 U/mL), and IFN-γ (14.64 ± 11.17 pg/mL) levels. There was a significantly positive correlation between periodontitis score and SLEDAI score (r = 0.927; p ≤ 0.0001), anti-dsDNA antibody (r = 0.948; p ≤ 0.0001), and IFN-γ (r = 0.951; p ≤ 0.0001) levels. Conclusion: Results of the present study demonstrated that periodontitis was associated with SLE disease activity, and was a biomarker of immune aging. Furthermore, this biomarker could be a reliable predictor of periodontal condition and prognosis of periodontitis and can also help in selecting the most appropriate treatment strategy for periodontitis in patients with SLE. الكلمات المفتاحية: الذئبة الحمامية المجموعية, التهاب اللثة, مقايسة الممتز المناعي المرتبط بالإنزيم (إلايسا), الأجسام المضادة لـلحمض النووي الريبي المختزل مزدوج الضفيرة, المضاد الضوئي المناعي, Keywords: Anti-dsDNA antibody, ELISA, IFN-γ, Periodontitis, SLE To analyse the correlation between periodontitis severity and disease activity, anti-double stranded DNA (anti-dsDNA) antibody, and interferon-gamma (IFN-γ) levels in patients with systemic lupus erythematous (SLE). We selected 61 patients with SLE (age 18-55 years) selected from a hospital in Malang, Indonesia. Clinical examination and laboratory tests were performed to assess disease activity. The severity of SLE was measured using the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), while periodontitis severity was measured according to the Periodontal Index (PI) criteria. Levels of anti-dsDNA and IFN-γ were determined using an enzyme-linked immunosorbent assay. Optical density at 450 nm was measured using an automated plate reader. The mean age of the subjects with SLE was 29 years, and mean disease duration was 2.8 years. Fifty-four of 61 (88.53%) subjects with SLE had periodontitis according to the PI. SLE subjects exhibited other clinical manifestations such as lupus nephritis, vasculitis, arthritis, mucocutaneous manifestation, fatigue, fever, and/or leukopenia. SLE severity was assessed according to the average SLEDAI score (17.70 ± 12.70), and average anti-dsDNA (122.6 ± 81.01 U/mL), and IFN-γ (14.64 ± 11.17 pg/mL) levels. There was a significantly positive correlation between periodontitis score and SLEDAI score (r = 0.927; p ≤ 0.0001), anti-dsDNA antibody (r = 0.948; p ≤ 0.0001), and IFN-γ (r = 0.951; p ≤ 0.0001) levels. Results of the present study demonstrated that periodontitis was associated with SLE disease activity, and was a biomarker of immune aging. Furthermore, this biomarker could be a reliable predictor of periodontal condition and prognosis of periodontitis and can also help in selecting the most appropriate treatment strategy for periodontitis in patients with SLE. To analyse the correlation between periodontitis severity and disease activity, anti-double stranded DNA (anti-dsDNA) antibody, and interferon-gamma (IFN-γ) levels in patients with systemic lupus erythematous (SLE).OBJECTIVESTo analyse the correlation between periodontitis severity and disease activity, anti-double stranded DNA (anti-dsDNA) antibody, and interferon-gamma (IFN-γ) levels in patients with systemic lupus erythematous (SLE).We selected 61 patients with SLE (age 18-55 years) selected from a hospital in Malang, Indonesia. Clinical examination and laboratory tests were performed to assess disease activity. The severity of SLE was measured using the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), while periodontitis severity was measured according to the Periodontal Index (PI) criteria. Levels of anti-dsDNA and IFN-γ were determined using an enzyme-linked immunosorbent assay. Optical density at 450 nm was measured using an automated plate reader.METHODSWe selected 61 patients with SLE (age 18-55 years) selected from a hospital in Malang, Indonesia. Clinical examination and laboratory tests were performed to assess disease activity. The severity of SLE was measured using the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), while periodontitis severity was measured according to the Periodontal Index (PI) criteria. Levels of anti-dsDNA and IFN-γ were determined using an enzyme-linked immunosorbent assay. Optical density at 450 nm was measured using an automated plate reader.The mean age of the subjects with SLE was 29 years, and mean disease duration was 2.8 years. Fifty-four of 61 (88.53%) subjects with SLE had periodontitis according to the PI. SLE subjects exhibited other clinical manifestations such as lupus nephritis, vasculitis, arthritis, mucocutaneous manifestation, fatigue, fever, and/or leukopenia. SLE severity was assessed according to the average SLEDAI score (17.70 ± 12.70), and average anti-dsDNA (122.6 ± 81.01 U/mL), and IFN-γ (14.64 ± 11.17 pg/mL) levels. There was a significantly positive correlation between periodontitis score and SLEDAI score (r = 0.927; p ≤ 0.0001), anti-dsDNA antibody (r = 0.948; p ≤ 0.0001), and IFN-γ (r = 0.951; p ≤ 0.0001) levels.RESULTSThe mean age of the subjects with SLE was 29 years, and mean disease duration was 2.8 years. Fifty-four of 61 (88.53%) subjects with SLE had periodontitis according to the PI. SLE subjects exhibited other clinical manifestations such as lupus nephritis, vasculitis, arthritis, mucocutaneous manifestation, fatigue, fever, and/or leukopenia. SLE severity was assessed according to the average SLEDAI score (17.70 ± 12.70), and average anti-dsDNA (122.6 ± 81.01 U/mL), and IFN-γ (14.64 ± 11.17 pg/mL) levels. There was a significantly positive correlation between periodontitis score and SLEDAI score (r = 0.927; p ≤ 0.0001), anti-dsDNA antibody (r = 0.948; p ≤ 0.0001), and IFN-γ (r = 0.951; p ≤ 0.0001) levels.Results of the present study demonstrated that periodontitis was associated with SLE disease activity, and was a biomarker of immune aging. Furthermore, this biomarker could be a reliable predictor of periodontal condition and prognosis of periodontitis and can also help in selecting the most appropriate treatment strategy for periodontitis in patients with SLE.CONCLUSIONResults of the present study demonstrated that periodontitis was associated with SLE disease activity, and was a biomarker of immune aging. Furthermore, this biomarker could be a reliable predictor of periodontal condition and prognosis of periodontitis and can also help in selecting the most appropriate treatment strategy for periodontitis in patients with SLE. |
| Author | Handono, Kusworini Nurdiana, Nurdiana Kalim, Handono Gofur, Nanda R.P. |
| AuthorAffiliation | b Department of Pharmacology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia a Doctoral Program of Medical Science, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia d Department of Pathology Clinic, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia c Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia |
| AuthorAffiliation_xml | – name: c Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia – name: d Department of Pathology Clinic, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia – name: b Department of Pharmacology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia – name: a Doctoral Program of Medical Science, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia |
| Author_xml | – sequence: 1 givenname: Nanda R.P. surname: Gofur fullname: Gofur, Nanda R.P. email: nanda.gofur@gmail.com organization: Doctoral Program of Medical Science, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia – sequence: 2 givenname: Nurdiana surname: Nurdiana fullname: Nurdiana, Nurdiana organization: Department of Pharmacology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia – sequence: 3 givenname: Handono surname: Kalim fullname: Kalim, Handono organization: Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia – sequence: 4 givenname: Kusworini surname: Handono fullname: Handono, Kusworini organization: Department of Pathology Clinic, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31908645$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1101/gad.235184.113 10.1016/j.jpeds.2007.09.019 10.1111/j.2041-1014.2009.00562.x 10.1016/j.archoralbio.2014.09.002 10.1159/000358904 10.1590/1677-3225v14n2a02 10.1111/jcpe.12528 10.1016/j.celrep.2016.12.047 10.1093/rheumatology/kem112 10.1111/jcpe.12936 10.14238/sp16.4.2014.292-8 10.21776/ub.eprodenta.2018.002.01.2 10.1371/journal.pone.0170209 10.1111/j.1600-0757.2012.00446.x |
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| Keywords | مقايسة الممتز المناعي المرتبط بالإنزيم (إلايسا) IFN-γ Periodontitis المضاد الضوئي المناعي الأجسام المضادة لـلحمض النووي الريبي المختزل مزدوج الضفيرة SLE الذئبة الحمامية المجموعية التهاب اللثة Anti-dsDNA antibody ELISA |
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| Snippet | لتحليل توافق شدة التهاب اللثة مع نشاط المرض، والأجسام المضادة لـلحمض النووي الريبي المختزل مزدوج الضفيرة والمضاد الضوئي المناعي في مرضى الذئبة الحمامية... To analyse the correlation between periodontitis severity and disease activity, anti-double stranded DNA (anti-dsDNA) antibody, and interferon-gamma (IFN-γ)... الملخص: أهداف البحث: لتحليل توافق شدة التهاب اللثة مع نشاط المرض، والأجسام المضادة لـلحمض النووي الريبي المختزل مزدوج الضفيرة والمضاد الضوئي المناعي في مرضى... |
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| SubjectTerms | Anti-dsDNA antibody ELISA IFN-γ Original Periodontitis SLE الأجسام المضادة لـلحمض النووي الريبي المختزل مزدوج الضفيرة التهاب اللثة الذئبة الحمامية المجموعية المضاد الضوئي المناعي مقايسة الممتز المناعي المرتبط بالإنزيم (إلايسا) |
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| Title | Periodontitis is associated with disease severity and anti-double stranded DNA antibody and interferon-gamma levels in patients with systemic lupus erythematosus |
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