The CD38/NAD/SIRTUIN1/EZH2 Axis Mitigates Cytotoxic CD8 T Cell Function and Identifies Patients with SLE Prone to Infections - Katsuyama, Eri; Suarez-Fueyo, Abel; Bradley, Sean J.; Mizui, Masayuki; Marin, Ana V.; Mulki, Lama; Krishfield, Suzanne; Malavasi, Fabio; Yoon, Joon; Sui, Shannan J. Ho; Kyttaris, Vasileios C.; Tsokos, George C. (Cell reports (Cambridge), 2020)
Keywords: ADP-ribosyl Cyclase 1 - metabolism; Adult; CD38; CD8 T cell; CD8-Positive T-Lymphocytes - immunology; Cell Line; cytotoxicity; Enhancer of Zeste Homolog 2 Protein - metabolism; EZH2; Female; Humans; infection; Infections - immunology; Lupus Erythematosus, Systemic - immunology; Lupus Erythematosus, Systemic - microbiology; Male; NAD - metabolism; nicotinamide adenine dinucleotide; patients; Sirtuin 1 - metabolism; Sirtuin1; systemic lupus erythematosus; T-Lymphocytes, Cytotoxic - immunology; Transcription Factors - metabolism; nicotinamide adenine dinucleotide; systemic lupus erythematosus; infection; CD8 T cell; patients; CD38; cytotoxicity; Sirtuin1; EZH2