p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis

• Published in: Molecular cell Vol. 77; no. 4; pp. 761 - 774.e8
• Main Authors: Olivero, Christiane E., Martínez-Terroba, Elena, Zimmer, Joshua, Liao, Clara, Tesfaye, Ephrath, Hooshdaran, Nima, Schofield, Jeremy A., Bendor, Jordan, Fang, Dorthy, Simon, Matthew D., Zamudio, Jesse R., Dimitrova, Nadya
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 20.02.2020
• Subjects: Animals; Carcinogenesis - genetics; Cell Line; Cell Proliferation; Cells, Cultured; Chromatin - metabolism; Enhancer Elements, Genetic; Gene Expression Regulation; Humans; long noncoding RNA; lung cancer; Lung Neoplasms - genetics; Lung Neoplasms - pathology; Mice; Mice, Inbred C57BL; mouse model of cancer; MYC; p53; Promoter Regions, Genetic; Proto-Oncogene Proteins c-myc - antagonists & inhibitors; Proto-Oncogene Proteins c-myc - genetics; Proto-Oncogene Proteins c-myc - metabolism; Pvt1; RNA, Long Noncoding - antagonists & inhibitors; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; Stress, Physiological - genetics; tumor suppressor; Tumor Suppressor Protein p53 - genetics; Tumor Suppressor Protein p53 - metabolism; lung cancer; Pvt1; MYC; long noncoding RNA; tumor suppressor; mouse model of cancer; p53

The tumor suppressor p53 transcriptionally activates target genes to suppress cellular proliferation during stress. p53 has also been implicated in the repression of the proto-oncogene Myc, but the mechanism has remained unclear. Here, we identify Pvt1b, a p53-dependent isoform of the long noncoding...