p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis
The tumor suppressor p53 transcriptionally activates target genes to suppress cellular proliferation during stress. p53 has also been implicated in the repression of the proto-oncogene Myc, but the mechanism has remained unclear. Here, we identify Pvt1b, a p53-dependent isoform of the long noncoding...
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| Published in | Molecular cell Vol. 77; no. 4; pp. 761 - 774.e8 |
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| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
20.02.2020
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| Abstract | The tumor suppressor p53 transcriptionally activates target genes to suppress cellular proliferation during stress. p53 has also been implicated in the repression of the proto-oncogene Myc, but the mechanism has remained unclear. Here, we identify Pvt1b, a p53-dependent isoform of the long noncoding RNA (lncRNA) Pvt1, expressed 50 kb downstream of Myc, which becomes induced by DNA damage or oncogenic signaling and accumulates near its site of transcription. We show that production of the Pvt1b RNA is necessary and sufficient to suppress Myc transcription in cis without altering the chromatin organization of the locus. Inhibition of Pvt1b increases Myc levels and transcriptional activity and promotes cellular proliferation. Furthermore, Pvt1b loss accelerates tumor growth, but not tumor progression, in an autochthonous mouse model of lung cancer. These findings demonstrate that Pvt1b acts at the intersection of the p53 and Myc transcriptional networks to reinforce the anti-proliferative activities of p53.
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•Pvt1b is a p53-dependent lncRNA isoform, induced by genotoxic and oncogenic stress•Production of Pvt1b RNA represses Myc transcription in cis•Pvt1b suppresses Myc transcriptional program and cellular proliferation•Pvt1b limits tumor growth, but not tumor progression, in a mouse lung tumor model
Olivero et al. identify the conserved lncRNA isoform Pvt1b as a locus-specific transcriptional regulator that serves to repress Myc transcription during the p53-mediated response to stress. Production of the Pvt1b RNA inhibits cellular proliferation and tumor growth, revealing tumor suppressor activities for this cancer-associated lncRNA. |
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| AbstractList | The tumor suppressor p53 transcriptionally activates target genes to suppress cellular proliferation during stress. p53 has also been implicated in the repression of the proto-oncogene Myc, but the mechanism has remained unclear. Here, we identify Pvt1b, a p53-dependent isoform of the long noncoding RNA (lncRNA) Pvt1, expressed 50 kb downstream of Myc, which becomes induced by DNA damage or oncogenic signaling and accumulates near its site of transcription. We show that production of the Pvt1b RNA is necessary and sufficient to suppress Myc transcription in cis without altering the chromatin organization of the locus. Inhibition of Pvt1b increases Myc levels and transcriptional activity and promotes cellular proliferation. Furthermore, Pvt1b loss accelerates tumor growth, but not tumor progression, in an autochthonous mouse model of lung cancer. These findings demonstrate that Pvt1b acts at the intersection of the p53 and Myc transcriptional networks to reinforce the anti-proliferative activities of p53.
[Display omitted]
•Pvt1b is a p53-dependent lncRNA isoform, induced by genotoxic and oncogenic stress•Production of Pvt1b RNA represses Myc transcription in cis•Pvt1b suppresses Myc transcriptional program and cellular proliferation•Pvt1b limits tumor growth, but not tumor progression, in a mouse lung tumor model
Olivero et al. identify the conserved lncRNA isoform Pvt1b as a locus-specific transcriptional regulator that serves to repress Myc transcription during the p53-mediated response to stress. Production of the Pvt1b RNA inhibits cellular proliferation and tumor growth, revealing tumor suppressor activities for this cancer-associated lncRNA. The tumor suppressor p53 transcriptionally activates target genes to suppress cellular proliferation during stress. p53 has also been implicated in the repression of the proto-oncogene Myc, but the mechanism has remained unclear. Here, we identify Pvt1b, a p53-dependent isoform of the long noncoding RNA (lncRNA) Pvt1, expressed 50 kb downstream of Myc, which becomes induced by DNA damage or oncogenic signaling and accumulates near its site of transcription. We show that production of the Pvt1b RNA is necessary and sufficient to suppress Myc transcription in cis without altering the chromatin organization of the locus. Inhibition of Pvt1b increases Myc levels and transcriptional activity and promotes cellular proliferation. Furthermore, Pvt1b loss accelerates tumor growth, but not tumor progression, in an autochthonous mouse model of lung cancer. These findings demonstrate that Pvt1b acts at the intersection of the p53 and Myc transcriptional networks to reinforce the anti-proliferative activities of p53.The tumor suppressor p53 transcriptionally activates target genes to suppress cellular proliferation during stress. p53 has also been implicated in the repression of the proto-oncogene Myc, but the mechanism has remained unclear. Here, we identify Pvt1b, a p53-dependent isoform of the long noncoding RNA (lncRNA) Pvt1, expressed 50 kb downstream of Myc, which becomes induced by DNA damage or oncogenic signaling and accumulates near its site of transcription. We show that production of the Pvt1b RNA is necessary and sufficient to suppress Myc transcription in cis without altering the chromatin organization of the locus. Inhibition of Pvt1b increases Myc levels and transcriptional activity and promotes cellular proliferation. Furthermore, Pvt1b loss accelerates tumor growth, but not tumor progression, in an autochthonous mouse model of lung cancer. These findings demonstrate that Pvt1b acts at the intersection of the p53 and Myc transcriptional networks to reinforce the anti-proliferative activities of p53. The tumor suppressor p53 transcriptionally activates target genes to suppress cellular proliferation during stress. p53 has also been implicated in the repression of the proto-oncogene Myc, but the mechanism has remained unclear. Here, we identify Pvt1b, a p53-dependent isoform of the long noncoding RNA (lncRNA) Pvt1, expressed 50 kb downstream of Myc, which becomes induced by DNA damage or oncogenic signaling and accumulates near its site of transcription. We show that production of the Pvt1b RNA is necessary and sufficient to suppress Myc transcription in cis without altering the chromatin organization of the locus. Inhibition of Pvt1b increases Myc levels and transcriptional activity and promotes cellular proliferation. Furthermore, Pvt1b loss accelerates tumor growth, but not tumor progression, in an autochthonous mouse model of lung cancer. These findings demonstrate that Pvt1b acts at the intersection of the p53 and Myc transcriptional networks to reinforce the anti-proliferative activities of p53. The tumor suppressor p53 transcriptionally activates target genes to suppress cellular proliferation during stress. p53 has also been implicated in the repression of the proto-oncogene Myc, but the mechanism has remained unclear. Here, we identify Pvt1b , a p53-dependent isoform of the long noncoding RNA (lncRNA) Pvt1 , expressed 50 Kb downstream of Myc , which becomes induced by DNA damage or oncogenic signaling and accumulates near its site of transcription. We show that production of the Pvt1b RNA is necessary and sufficient to suppress Myc transcription in cis without altering the chromatin organization of the locus. Inhibition of Pvt1b increases Myc levels and transcriptional activity and promotes cellular proliferation. Furthermore, Pvt1b loss accelerates tumor growth, but not tumor progression, in an autochthonous mouse model of lung cancer. These findings demonstrate that Pvt1b acts at the intersection of the p53 and Myc transcriptional networks to reinforce the anti-proliferative activities of p53. Olivero et al. identify the conserved lncRNA isoform Pvt1b as a locus-specific transcriptional regulator that serves to repress Myc transcription during the p53-mediated response to stress. Production of the Pvt1b RNA inhibits cellular proliferation and tumor growth, revealing tumor suppressor activities for this cancer-associated lncRNA. |
| Author | Dimitrova, Nadya Hooshdaran, Nima Martínez-Terroba, Elena Zamudio, Jesse R. Zimmer, Joshua Simon, Matthew D. Olivero, Christiane E. Tesfaye, Ephrath Bendor, Jordan Liao, Clara Fang, Dorthy Schofield, Jeremy A. |
| AuthorAffiliation | 1 Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511 3 Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, CA 90095 2 Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511 |
| AuthorAffiliation_xml | – name: 2 Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511 – name: 1 Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511 – name: 3 Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, CA 90095 |
| Author_xml | – sequence: 1 givenname: Christiane E. surname: Olivero fullname: Olivero, Christiane E. organization: Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA – sequence: 2 givenname: Elena surname: Martínez-Terroba fullname: Martínez-Terroba, Elena organization: Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA – sequence: 3 givenname: Joshua surname: Zimmer fullname: Zimmer, Joshua organization: Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511, USA – sequence: 4 givenname: Clara surname: Liao fullname: Liao, Clara organization: Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA – sequence: 5 givenname: Ephrath surname: Tesfaye fullname: Tesfaye, Ephrath organization: Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA – sequence: 6 givenname: Nima surname: Hooshdaran fullname: Hooshdaran, Nima organization: Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA – sequence: 7 givenname: Jeremy A. surname: Schofield fullname: Schofield, Jeremy A. organization: Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511, USA – sequence: 8 givenname: Jordan surname: Bendor fullname: Bendor, Jordan organization: Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA – sequence: 9 givenname: Dorthy surname: Fang fullname: Fang, Dorthy organization: Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA – sequence: 10 givenname: Matthew D. surname: Simon fullname: Simon, Matthew D. organization: Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511, USA – sequence: 11 givenname: Jesse R. surname: Zamudio fullname: Zamudio, Jesse R. organization: Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA – sequence: 12 givenname: Nadya surname: Dimitrova fullname: Dimitrova, Nadya email: nadya.dimitrova@yale.edu organization: Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31973890$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1074/jbc.M111.322875 10.1038/nature13311 10.1038/nmeth.3317 10.1016/j.celrep.2016.07.050 10.1016/j.molcel.2017.07.028 10.1101/gad.943001 10.1261/rna.2192803 10.1186/s12935-018-0582-3 10.1038/nature13589 10.1038/nature20149 10.1128/MCB.25.17.7423-7431.2005 10.1158/0008-5472.CAN-12-0213 10.1038/nbt.3122 10.1158/0008-5472.CAN-03-3376 10.1002/jcp.26072 10.1371/journal.pone.0052249 10.1093/bioinformatics/bts635 10.1158/1078-0432.CCR-06-2882 10.1002/j.1460-2075.1985.tb03682.x 10.4161/23723556.2014.974467 10.1002/j.1460-2075.1986.tb04578.x 10.14806/ej.17.1.200 10.1038/nmeth.4582 10.1097/JTO.0000000000000202 10.1016/j.cell.2018.01.011 10.1016/j.cell.2009.04.037 10.1016/j.bbrc.2015.12.101 10.18632/oncotarget.20634 10.1038/314740a0 10.1093/bioinformatics/btu638 10.1093/bioinformatics/btp352 10.1016/j.cell.2012.08.026 10.1038/nature11327 10.18632/oncotarget.22830 10.1186/s12943-015-0355-8 10.1007/978-1-59745-406-3_18 10.1186/s13059-014-0550-8 10.3892/ol.2016.5026 10.1038/nature19346 10.1038/nprot.2009.95 10.1038/nprot.2007.243 10.7554/eLife.03058 10.1016/j.celrep.2018.10.027 10.1038/nature05541 10.1093/bioinformatics/btp120 10.1038/onc.2013.490 10.1073/pnas.0808042106 10.1158/1078-0432.CCR-16-0742 10.1016/j.cell.2018.03.068 10.1016/j.cels.2015.12.004 10.1038/cdd.2017.172 10.1126/science.1231776 10.1038/nbt.3390 10.1016/j.molcel.2014.04.025 10.1002/gcc.22076 10.1128/MCB.13.12.7942 10.1093/bioinformatics/btp616 10.1038/nrc2723 10.1038/nature09535 10.1158/0008-5472.CAN-05-2193 10.1007/978-1-4939-4035-6_1 10.1016/j.cell.2014.09.014 |
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| Keywords | lung cancer Pvt1 MYC long noncoding RNA tumor suppressor mouse model of cancer p53 |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Lead contact: nadya.dimitrova@yale.edu Author contribution CO and ND conceived the project, analyzed data, prepared figures, and wrote the manuscript. CO performed and analyzed in vitro experiments. EM performed CRISPRa and analyzed mutagenesis in vivo. CL, JB, and ND maintained mice, performed and analyzed in vivo experiments. NH and JZ analyzed sequencing data. JZ, JS, and MS performed and analyzed nascent RNA-seq. ET performed subcellular fractionation and DF performed DNA FISH. |
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| References | Chaumeil, Augui, Chow, Heard (bib4) 2008; 463 Jackson, Willis, Mercer, Bronson, Crowley, Montoya, Jacks, Tuveson (bib26) 2001; 15 Liberzon, Birger, Thorvaldsdóttir, Ghandi, Mesirov, Tamayo (bib37) 2015; 1 Dahlman, Abudayyeh, Joung, Gootenberg, Zhang, Konermann (bib10) 2015; 33 Pertea, Pertea, Antonescu, Chang, Mendell, Salzberg (bib62) 2015; 33 Zhang, Yang, Luo (bib55) 2019; 17 Hagège, Klous, Braem, Splinter, Dekker, Cathala, de Laat, Forné (bib23) 2007; 2 Tseng, Bagchi (bib48) 2015; 2 Schofield, Duffy, Kiefer, Sullivan, Simon (bib46) 2018; 15 Love, Huber, Anders (bib64) 2014; 15 Lee (bib33) 2012; 338 Stewart, Dykxhoorn, Palliser, Mizuno, Yu, An, Sabatini, Chen, Hahn, Sharp (bib61) 2003; 9 Nagoshi, Taki, Hanamura, Nitta, Otsuki, Nishida, Okuda, Sakamoto, Kobayashi, Yamamoto-Sugitani (bib38) 2012; 72 Robinson, McCarthy, Smyth (bib44) 2010; 26 Groff, Sanchez-Gomez, Soruco, Gerhardinger, Barutcu, Li, Elcavage, Plana, Sanchez, Lee (bib20) 2016; 16 Kong, Zhang, Yin, You, Xu, Chen, Xia, Wan, Sun, Wang (bib30) 2015; 14 DuPage, Dooley, Jacks (bib13) 2009; 4 Guan, Kuo, Stilwell, Takano, Lapuk, Fridlyand, Mao, Yu, Miller, Santos (bib21) 2007; 13 Anders, Pyl, Huber (bib1) 2015; 31 Li, Handsaker, Wysoker, Fennell, Ruan, Homer, Marth, Abecasis, Durbin (bib36) 2009; 25 Jackson, Olive, Tuveson, Bronson, Crowley, Brown, Jacks (bib27) 2005; 65 Xue, Chen, Yin, Tammela, Papagiannakopoulos, Joshi, Cai, Yang, Bronson, Crowley (bib60) 2014; 514 Conrad, Ørom (bib7) 2017; 1468 Dimitrova, Zamudio, Jong, Soukup, Resnick, Sarma, Ward, Raj, Lee, Sharp, Jacks (bib11) 2014; 54 Dobin, Davis, Schlesinger, Drenkow, Zaleski, Jha, Batut, Chaisson, Gingeras (bib12) 2013; 29 Graham, Adams, Cory (bib19) 1985; 314 Porter, Fisher, Baranello, Liu, Kambach, Nie, Koh, Luo, Stommel, Levens (bib42) 2017; 67 Riquelme, Suraokar, Rodriguez, Mino, Lin, Rice, Tsao, Wistuba (bib43) 2014; 9 Ventura, Kirsch, McLaughlin, Tuveson, Grimm, Lintault, Newman, Reczek, Weissleder, Jacks (bib50) 2007; 445 Zeng, Wang, Liu, Su, Lu, Chen, Hu (bib54) 2017; 8 Feldser, Kostova, Winslow, Taylor, Cashman, Whittaker, Sanchez-Rivera, Resnick, Bronson, Hemann, Jacks (bib17) 2010; 468 Xu, Luo, Qian, Pang, Song, Qian, Chen, Chen (bib52) 2012; 7 Cui, You, Ren, Zhao, Liao, Zhao (bib9) 2016; 471 Kopp, Mendell (bib31) 2018; 172 Engreitz, Haines, Perez, Munson, Chen, Kane, McDonel, Guttman, Lander (bib16) 2016; 539 Kim, Cho, Han, Shin, Jeong, Song, Lee, Lee, Bang, Seo (bib28) 2014; 33 Trapnell, Pachter, Salzberg (bib47) 2009; 25 Xu, Wang, Weng, Wei, Qi, Zhang, Tan, Ni, Dong, Yang (bib53) 2017; 23 Kim, Langmead, Salzberg (bib29) 2015; 12 Vousden, Prives (bib51) 2009; 137 Iwakawa, Takenaka, Kohno, Shimada, Totoki, Shibata, Tsuta, Nishikawa, Noguchi, Sato-Otsubo (bib25) 2013; 52 Kotzin, Spencer, McCright, Kumar, Collet, Mowel, Elliott, Uyar, Makiya, Dunagin (bib32) 2016; 537 Tseng, Moriarity, Gong, Akiyama, Tiwari, Kawakami, Ronning, Reuland, Guenther, Beadnell (bib49) 2014; 512 Clarke, Gledhill, Hooper, Bird, Wyllie (bib6) 1994; 9 Zhu, Shuai, Yang, Zhang, Zhong, Liu, Chen, Ran, Yang, Zhou (bib58) 2017; 8 Sachdeva, Zhu, Wu, Wu, Walia, Kumar, Elble, Watabe, Mo (bib45) 2009; 106 Cory, Graham, Webb, Corcoran, Adams (bib8) 1985; 4 Levine, Oren (bib34) 2009; 9 Northcott, Shih, Peacock, Garzia, Morrissy, Zichner, Stütz, Korshunov, Reimand, Schumacher (bib40) 2012; 488 Guo, Hao, Wang, Li (bib22) 2018; 18 Barsotti, Beckerman, Laptenko, Huppi, Caplen, Prives (bib2) 2012; 287 Elling, Robinson, Shapleigh, Liapis, Covarrubias, Katzman, Groff, Jiang, Agarwal, Motwani (bib14) 2018; 25 Nikitin, Alcaraz, Anver, Bronson, Cardiff, Dixon, Fraire, Gabrielson, Gunning, Haines (bib39) 2004; 64 Cho, Xu, Sun, Mumbach, Carter, Chen, Yost, Kim, He, Nevins (bib5) 2018; 173 Ho, Ma, Mao, Benchimol (bib24) 2005; 25 Levy, Yonish-Rouach, Oren, Kimchi (bib35) 1993; 13 Zheng, Hu, Li (bib57) 2016; 12 Graham, Adams (bib18) 1986; 5 Bassett, Akhtar, Barlow, Bird, Brockdorff, Duboule, Ephrussi, Ferguson-Smith, Gingeras, Haerty (bib3) 2014; 3 Platt, Chen, Zhou, Yim, Swiech, Kempton, Dahlman, Parnas, Eisenhaure, Jovanovic (bib41) 2014; 159 Zhao, Kong, Sun, Chen, Chen, Zhou (bib56) 2018; 233 Engeland (bib15) 2018; 25 Lin, Lovén, Rahl, Paranal, Burge, Bradner, Lee, Young (bib59) 2012; 151 Martin (bib63) 2011; 17 Zheng (10.1016/j.molcel.2019.12.014_bib57) 2016; 12 Dobin (10.1016/j.molcel.2019.12.014_bib12) 2013; 29 Li (10.1016/j.molcel.2019.12.014_bib36) 2009; 25 Anders (10.1016/j.molcel.2019.12.014_bib1) 2015; 31 Jackson (10.1016/j.molcel.2019.12.014_bib26) 2001; 15 Lin (10.1016/j.molcel.2019.12.014_bib59) 2012; 151 Iwakawa (10.1016/j.molcel.2019.12.014_bib25) 2013; 52 Platt (10.1016/j.molcel.2019.12.014_bib41) 2014; 159 Martin (10.1016/j.molcel.2019.12.014_bib63) 2011; 17 Engreitz (10.1016/j.molcel.2019.12.014_bib16) 2016; 539 Levy (10.1016/j.molcel.2019.12.014_bib35) 1993; 13 Bassett (10.1016/j.molcel.2019.12.014_bib3) 2014; 3 Cory (10.1016/j.molcel.2019.12.014_bib8) 1985; 4 Elling (10.1016/j.molcel.2019.12.014_bib14) 2018; 25 DuPage (10.1016/j.molcel.2019.12.014_bib13) 2009; 4 Liberzon (10.1016/j.molcel.2019.12.014_bib37) 2015; 1 Kong (10.1016/j.molcel.2019.12.014_bib30) 2015; 14 Dahlman (10.1016/j.molcel.2019.12.014_bib10) 2015; 33 Riquelme (10.1016/j.molcel.2019.12.014_bib43) 2014; 9 Northcott (10.1016/j.molcel.2019.12.014_bib40) 2012; 488 Tseng (10.1016/j.molcel.2019.12.014_bib48) 2015; 2 Kotzin (10.1016/j.molcel.2019.12.014_bib32) 2016; 537 Cui (10.1016/j.molcel.2019.12.014_bib9) 2016; 471 Barsotti (10.1016/j.molcel.2019.12.014_bib2) 2012; 287 Cho (10.1016/j.molcel.2019.12.014_bib5) 2018; 173 Feldser (10.1016/j.molcel.2019.12.014_bib17) 2010; 468 Tseng (10.1016/j.molcel.2019.12.014_bib49) 2014; 512 Porter (10.1016/j.molcel.2019.12.014_bib42) 2017; 67 Sachdeva (10.1016/j.molcel.2019.12.014_bib45) 2009; 106 Love (10.1016/j.molcel.2019.12.014_bib64) 2014; 15 Stewart (10.1016/j.molcel.2019.12.014_bib61) 2003; 9 Nikitin (10.1016/j.molcel.2019.12.014_bib39) 2004; 64 Zhao (10.1016/j.molcel.2019.12.014_bib56) 2018; 233 Graham (10.1016/j.molcel.2019.12.014_bib18) 1986; 5 Guo (10.1016/j.molcel.2019.12.014_bib22) 2018; 18 Zhu (10.1016/j.molcel.2019.12.014_bib58) 2017; 8 Hagège (10.1016/j.molcel.2019.12.014_bib23) 2007; 2 Dimitrova (10.1016/j.molcel.2019.12.014_bib11) 2014; 54 Engeland (10.1016/j.molcel.2019.12.014_bib15) 2018; 25 Kim (10.1016/j.molcel.2019.12.014_bib29) 2015; 12 Schofield (10.1016/j.molcel.2019.12.014_bib46) 2018; 15 Pertea (10.1016/j.molcel.2019.12.014_bib62) 2015; 33 Xu (10.1016/j.molcel.2019.12.014_bib52) 2012; 7 Levine (10.1016/j.molcel.2019.12.014_bib34) 2009; 9 Jackson (10.1016/j.molcel.2019.12.014_bib27) 2005; 65 Lee (10.1016/j.molcel.2019.12.014_bib33) 2012; 338 Zhang (10.1016/j.molcel.2019.12.014_bib55) 2019; 17 Nagoshi (10.1016/j.molcel.2019.12.014_bib38) 2012; 72 Robinson (10.1016/j.molcel.2019.12.014_bib44) 2010; 26 Zeng (10.1016/j.molcel.2019.12.014_bib54) 2017; 8 Guan (10.1016/j.molcel.2019.12.014_bib21) 2007; 13 Chaumeil (10.1016/j.molcel.2019.12.014_bib4) 2008; 463 Ho (10.1016/j.molcel.2019.12.014_bib24) 2005; 25 Vousden (10.1016/j.molcel.2019.12.014_bib51) 2009; 137 Conrad (10.1016/j.molcel.2019.12.014_bib7) 2017; 1468 Kopp (10.1016/j.molcel.2019.12.014_bib31) 2018; 172 Ventura (10.1016/j.molcel.2019.12.014_bib50) 2007; 445 Clarke (10.1016/j.molcel.2019.12.014_bib6) 1994; 9 Xue (10.1016/j.molcel.2019.12.014_bib60) 2014; 514 Kim (10.1016/j.molcel.2019.12.014_bib28) 2014; 33 Graham (10.1016/j.molcel.2019.12.014_bib19) 1985; 314 Groff (10.1016/j.molcel.2019.12.014_bib20) 2016; 16 Xu (10.1016/j.molcel.2019.12.014_bib53) 2017; 23 Trapnell (10.1016/j.molcel.2019.12.014_bib47) 2009; 25 |
| References_xml | – volume: 54 start-page: 777 year: 2014 end-page: 790 ident: bib11 article-title: LincRNA-p21 activates p21 in cis to promote Polycomb target gene expression and to enforce the G1/S checkpoint publication-title: Mol. Cell – volume: 25 start-page: 1105 year: 2009 end-page: 1111 ident: bib47 article-title: TopHat: discovering splice junctions with RNA-Seq publication-title: Bioinformatics – volume: 33 start-page: 1159 year: 2015 end-page: 1161 ident: bib10 article-title: Orthogonal gene knockout and activation with a catalytically active Cas9 nuclease publication-title: Nat. Biotechnol. – volume: 33 start-page: 5434 year: 2014 end-page: 5441 ident: bib28 article-title: Novel fusion transcripts in human gastric cancer revealed by transcriptome analysis publication-title: Oncogene – volume: 9 start-page: 998 year: 2014 end-page: 1007 ident: bib43 article-title: Frequent coamplification and cooperation between C-MYC and PVT1 oncogenes promote malignant pleural mesothelioma publication-title: J. Thorac. Oncol. – volume: 338 start-page: 1435 year: 2012 end-page: 1439 ident: bib33 article-title: Epigenetic regulation by long noncoding RNAs publication-title: Science – volume: 15 start-page: 3243 year: 2001 end-page: 3248 ident: bib26 article-title: Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras publication-title: Genes Dev. – volume: 8 start-page: 113174 year: 2017 end-page: 113184 ident: bib58 article-title: Prognostic value of long non-coding RNA PVT1 as a novel biomarker in various cancers: a meta-analysis publication-title: Oncotarget – volume: 25 start-page: 2078 year: 2009 end-page: 2079 ident: bib36 article-title: The Sequence Alignment/Map format and SAMtools publication-title: Bioinformatics – volume: 233 start-page: 4044 year: 2018 end-page: 4055 ident: bib56 article-title: LncRNA-PVT1 promotes pancreatic cancer cells proliferation and migration through acting as a molecular sponge to regulate miR-448 publication-title: J. Cell. Physiol. – volume: 514 start-page: 380 year: 2014 end-page: 384 ident: bib60 article-title: CRISPR-mediated direct mutation of cancer genes in the mouse liver publication-title: Nature – volume: 31 start-page: 166 year: 2015 end-page: 169 ident: bib1 article-title: HTSeq—a Python framework to work with high-throughput sequencing data publication-title: Bioinformatics – volume: 3 start-page: e03058 year: 2014 ident: bib3 article-title: Considerations when investigating lncRNA function in vivo publication-title: eLife – volume: 9 start-page: 1767 year: 1994 end-page: 1773 ident: bib6 article-title: p53 dependence of early apoptotic and proliferative responses within the mouse intestinal epithelium following gamma-irradiation publication-title: Oncogene – volume: 65 start-page: 10280 year: 2005 end-page: 10288 ident: bib27 article-title: The differential effects of mutant p53 alleles on advanced murine lung cancer publication-title: Cancer Res. – volume: 12 start-page: 357 year: 2015 end-page: 360 ident: bib29 article-title: HISAT: a fast spliced aligner with low memory requirements publication-title: Nat. Methods – volume: 64 start-page: 2307 year: 2004 end-page: 2316 ident: bib39 article-title: Classification of proliferative pulmonary lesions of the mouse: recommendations of the mouse models of human cancers consortium publication-title: Cancer Res. – volume: 15 start-page: 221 year: 2018 end-page: 225 ident: bib46 article-title: TimeLapse-seq: adding a temporal dimension to RNA sequencing through nucleoside recoding publication-title: Nat. Methods – volume: 14 start-page: 82 year: 2015 ident: bib30 article-title: Long noncoding RNA PVT1 indicates a poor prognosis of gastric cancer and promotes cell proliferation through epigenetically regulating p15 and p16 publication-title: Mol. Cancer – volume: 17 start-page: 10 year: 2011 end-page: 12 ident: bib63 article-title: Cutadapt removes adapter sequences from high-throughput sequencing reads publication-title: EMBnet.journal – volume: 9 start-page: 493 year: 2003 end-page: 501 ident: bib61 article-title: Lentivirus-delivered stable gene silencing by RNAi in primary cells publication-title: RNA – volume: 7 start-page: e52249 year: 2012 ident: bib52 article-title: FastUniq: a fast de novo duplicates removal tool for paired short reads publication-title: PLoS ONE – volume: 137 start-page: 413 year: 2009 end-page: 431 ident: bib51 article-title: Blinded by the light: the growing complexity of p53 publication-title: Cell – volume: 5 start-page: 2845 year: 1986 end-page: 2851 ident: bib18 article-title: Chromosome 8 breakpoint far 3′ of the c-myc oncogene in a Burkitt’s lymphoma 2;8 variant translocation is equivalent to the murine pvt-1 locus publication-title: EMBO J. – volume: 8 start-page: 75455 year: 2017 end-page: 75466 ident: bib54 article-title: LncRNA PVT1 as an effective biomarker for cancer diagnosis and detection based on transcriptome data and meta-analysis publication-title: Oncotarget – volume: 29 start-page: 15 year: 2013 end-page: 21 ident: bib12 article-title: STAR: ultrafast universal RNA-seq aligner publication-title: Bioinformatics – volume: 25 start-page: 7423 year: 2005 end-page: 7431 ident: bib24 article-title: p53-dependent transcriptional repression of c-myc is required for G1 cell cycle arrest publication-title: Mol. Cell. Biol. – volume: 13 start-page: 7942 year: 1993 end-page: 7952 ident: bib35 article-title: Complementation by wild-type p53 of interleukin-6 effects on M1 cells: induction of cell cycle exit and cooperativity with c-myc suppression publication-title: Mol. Cell. Biol. – volume: 445 start-page: 661 year: 2007 end-page: 665 ident: bib50 article-title: Restoration of p53 function leads to tumour regression in vivo publication-title: Nature – volume: 287 start-page: 2509 year: 2012 end-page: 2519 ident: bib2 article-title: p53-dependent induction of PVT1 and miR-1204 publication-title: J. Biol. Chem. – volume: 1 start-page: 417 year: 2015 end-page: 425 ident: bib37 article-title: The Molecular Signatures Database (MSigDB) hallmark gene set collection publication-title: Cell Syst. – volume: 33 start-page: 290 year: 2015 end-page: 295 ident: bib62 article-title: StringTie enables improved reconstruction of a transcriptome from RNA-seq reads publication-title: Nat. Biotechnol. – volume: 16 start-page: 2178 year: 2016 end-page: 2186 ident: bib20 article-title: In vivo characterization of linc-p21 reveals functional cis-regulatory DNA elements publication-title: Cell Rep. – volume: 67 start-page: 1013 year: 2017 end-page: 1025 e9 ident: bib42 article-title: Global inhibition with specific activation: how p53 and MYC redistribute the transcriptome in the DNA double-strand break response publication-title: Mol. Cell – volume: 1468 start-page: 1 year: 2017 end-page: 9 ident: bib7 article-title: Cellular fractionation and isolation of chromatin-associated RNA publication-title: Methods Mol. Biol. – volume: 13 start-page: 5745 year: 2007 end-page: 5755 ident: bib21 article-title: Amplification of PVT1 contributes to the pathophysiology of ovarian and breast cancer publication-title: Clin. Cancer Res. – volume: 12 start-page: 2357 year: 2016 end-page: 2362 ident: bib57 article-title: High expression of lncRNA PVT1 promotes invasion by inducing epithelial-to-mesenchymal transition in esophageal cancer publication-title: Oncol. Lett. – volume: 463 start-page: 297 year: 2008 end-page: 308 ident: bib4 article-title: Combined immunofluorescence, RNA fluorescent in situ hybridization, and DNA fluorescent in situ hybridization to study chromatin changes, transcriptional activity, nuclear organization, and X-chromosome inactivation publication-title: Methods Mol. Biol. – volume: 25 start-page: 114 year: 2018 end-page: 132 ident: bib15 article-title: Cell cycle arrest through indirect transcriptional repression by p53: I have a DREAM publication-title: Cell Death Differ. – volume: 159 start-page: 440 year: 2014 end-page: 455 ident: bib41 article-title: CRISPR-Cas9 knockin mice for genome editing and cancer modeling publication-title: Cell – volume: 72 start-page: 4954 year: 2012 end-page: 4962 ident: bib38 article-title: Frequent PVT1 rearrangement and novel chimeric genes PVT1-NBEA and PVT1-WWOX occur in multiple myeloma with 8q24 abnormality publication-title: Cancer Res. – volume: 17 start-page: 1337 year: 2019 end-page: 1345 ident: bib55 article-title: Long non-coding RNA PVT1 promotes glioma cell proliferation and invasion by targeting miR-200a publication-title: Exp. Ther. Med. – volume: 26 start-page: 139 year: 2010 end-page: 140 ident: bib44 article-title: edgeR: a Bioconductor package for differential expression analysis of digital gene expression data publication-title: Bioinformatics – volume: 539 start-page: 452 year: 2016 end-page: 455 ident: bib16 article-title: Local regulation of gene expression by lncRNA promoters, transcription and splicing publication-title: Nature – volume: 488 start-page: 49 year: 2012 end-page: 56 ident: bib40 article-title: Subgroup-specific structural variation across 1,000 medulloblastoma genomes publication-title: Nature – volume: 15 start-page: 550 year: 2014 ident: bib64 article-title: Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 publication-title: Genome Biol. – volume: 23 start-page: 2071 year: 2017 end-page: 2080 ident: bib53 article-title: A positive feedback loop of lncRNA- publication-title: Clin. Cancer Res. – volume: 151 start-page: 56 year: 2012 end-page: 67 ident: bib59 article-title: Transcriptional amplification in tumor cells with elevated c-Myc publication-title: Cell – volume: 468 start-page: 572 year: 2010 end-page: 575 ident: bib17 article-title: Stage-specific sensitivity to p53 restoration during lung cancer progression publication-title: Nature – volume: 172 start-page: 393 year: 2018 end-page: 407 ident: bib31 article-title: Functional classification and experimental dissection of long noncoding RNAs publication-title: Cell – volume: 512 start-page: 82 year: 2014 end-page: 86 ident: bib49 article-title: PVT1 dependence in cancer with MYC copy-number increase publication-title: Nature – volume: 2 start-page: 1722 year: 2007 end-page: 1733 ident: bib23 article-title: Quantitative analysis of chromosome conformation capture assays (3C-qPCR) publication-title: Nat. Protoc. – volume: 471 start-page: 10 year: 2016 end-page: 14 ident: bib9 article-title: Long non-coding RNA PVT1 and cancer publication-title: Biochem. Biophys. Res. Commun. – volume: 537 start-page: 239 year: 2016 end-page: 243 ident: bib32 article-title: The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan publication-title: Nature – volume: 173 start-page: 1398 year: 2018 end-page: 1412.e22 ident: bib5 article-title: Promoter of lncRNA gene PVT1 is a tumor-suppressor DNA boundary element publication-title: Cell – volume: 4 start-page: 675 year: 1985 end-page: 681 ident: bib8 article-title: Variant (6;15) translocations in murine plasmacytomas involve a chromosome 15 locus at least 72 kb from the c-myc oncogene publication-title: EMBO J. – volume: 4 start-page: 1064 year: 2009 end-page: 1072 ident: bib13 article-title: Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase publication-title: Nat. Protoc. – volume: 52 start-page: 802 year: 2013 end-page: 816 ident: bib25 article-title: Genome-wide identification of genes with amplification and/or fusion in small cell lung cancer publication-title: Genes Chromosomes Cancer – volume: 314 start-page: 740 year: 1985 end-page: 743 ident: bib19 article-title: Murine T lymphomas with retroviral inserts in the chromosomal 15 locus for plasmacytoma variant translocations publication-title: Nature – volume: 18 start-page: 98 year: 2018 ident: bib22 article-title: Long noncoding RNA PVT1 modulates hepatocellular carcinoma cell proliferation and apoptosis by recruiting EZH2 publication-title: Cancer Cell Int. – volume: 2 start-page: e974467 year: 2015 ident: bib48 article-title: The PVT1-MYC duet in cancer publication-title: Mol. Cell. Oncol. – volume: 25 start-page: 1511 year: 2018 end-page: 1524.e6 ident: bib14 article-title: Genetic models reveal cis and trans immune-regulatory activities for lincRNA-Cox2 publication-title: Cell Rep. – volume: 106 start-page: 3207 year: 2009 end-page: 3212 ident: bib45 article-title: p53 represses c-Myc through induction of the tumor suppressor miR-145 publication-title: Proc. Natl. Acad. Sci. U S A – volume: 9 start-page: 749 year: 2009 end-page: 758 ident: bib34 article-title: The first 30 years of p53: growing ever more complex publication-title: Nat. Rev. Cancer – volume: 287 start-page: 2509 year: 2012 ident: 10.1016/j.molcel.2019.12.014_bib2 article-title: p53-dependent induction of PVT1 and miR-1204 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M111.322875 – volume: 512 start-page: 82 year: 2014 ident: 10.1016/j.molcel.2019.12.014_bib49 article-title: PVT1 dependence in cancer with MYC copy-number increase publication-title: Nature doi: 10.1038/nature13311 – volume: 12 start-page: 357 year: 2015 ident: 10.1016/j.molcel.2019.12.014_bib29 article-title: HISAT: a fast spliced aligner with low memory requirements publication-title: Nat. Methods doi: 10.1038/nmeth.3317 – volume: 16 start-page: 2178 year: 2016 ident: 10.1016/j.molcel.2019.12.014_bib20 article-title: In vivo characterization of linc-p21 reveals functional cis-regulatory DNA elements publication-title: Cell Rep. doi: 10.1016/j.celrep.2016.07.050 – volume: 67 start-page: 1013 year: 2017 ident: 10.1016/j.molcel.2019.12.014_bib42 article-title: Global inhibition with specific activation: how p53 and MYC redistribute the transcriptome in the DNA double-strand break response publication-title: Mol. Cell doi: 10.1016/j.molcel.2017.07.028 – volume: 15 start-page: 3243 year: 2001 ident: 10.1016/j.molcel.2019.12.014_bib26 article-title: Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras publication-title: Genes Dev. doi: 10.1101/gad.943001 – volume: 9 start-page: 493 year: 2003 ident: 10.1016/j.molcel.2019.12.014_bib61 article-title: Lentivirus-delivered stable gene silencing by RNAi in primary cells publication-title: RNA doi: 10.1261/rna.2192803 – volume: 18 start-page: 98 year: 2018 ident: 10.1016/j.molcel.2019.12.014_bib22 article-title: Long noncoding RNA PVT1 modulates hepatocellular carcinoma cell proliferation and apoptosis by recruiting EZH2 publication-title: Cancer Cell Int. doi: 10.1186/s12935-018-0582-3 – volume: 514 start-page: 380 year: 2014 ident: 10.1016/j.molcel.2019.12.014_bib60 article-title: CRISPR-mediated direct mutation of cancer genes in the mouse liver publication-title: Nature doi: 10.1038/nature13589 – volume: 539 start-page: 452 year: 2016 ident: 10.1016/j.molcel.2019.12.014_bib16 article-title: Local regulation of gene expression by lncRNA promoters, transcription and splicing publication-title: Nature doi: 10.1038/nature20149 – volume: 25 start-page: 7423 year: 2005 ident: 10.1016/j.molcel.2019.12.014_bib24 article-title: p53-dependent transcriptional repression of c-myc is required for G1 cell cycle arrest publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.25.17.7423-7431.2005 – volume: 72 start-page: 4954 year: 2012 ident: 10.1016/j.molcel.2019.12.014_bib38 article-title: Frequent PVT1 rearrangement and novel chimeric genes PVT1-NBEA and PVT1-WWOX occur in multiple myeloma with 8q24 abnormality publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-12-0213 – volume: 33 start-page: 290 year: 2015 ident: 10.1016/j.molcel.2019.12.014_bib62 article-title: StringTie enables improved reconstruction of a transcriptome from RNA-seq reads publication-title: Nat. Biotechnol. doi: 10.1038/nbt.3122 – volume: 64 start-page: 2307 year: 2004 ident: 10.1016/j.molcel.2019.12.014_bib39 article-title: Classification of proliferative pulmonary lesions of the mouse: recommendations of the mouse models of human cancers consortium publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-03-3376 – volume: 233 start-page: 4044 year: 2018 ident: 10.1016/j.molcel.2019.12.014_bib56 article-title: LncRNA-PVT1 promotes pancreatic cancer cells proliferation and migration through acting as a molecular sponge to regulate miR-448 publication-title: J. Cell. Physiol. doi: 10.1002/jcp.26072 – volume: 7 start-page: e52249 year: 2012 ident: 10.1016/j.molcel.2019.12.014_bib52 article-title: FastUniq: a fast de novo duplicates removal tool for paired short reads publication-title: PLoS ONE doi: 10.1371/journal.pone.0052249 – volume: 29 start-page: 15 year: 2013 ident: 10.1016/j.molcel.2019.12.014_bib12 article-title: STAR: ultrafast universal RNA-seq aligner publication-title: Bioinformatics doi: 10.1093/bioinformatics/bts635 – volume: 13 start-page: 5745 year: 2007 ident: 10.1016/j.molcel.2019.12.014_bib21 article-title: Amplification of PVT1 contributes to the pathophysiology of ovarian and breast cancer publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-06-2882 – volume: 4 start-page: 675 year: 1985 ident: 10.1016/j.molcel.2019.12.014_bib8 article-title: Variant (6;15) translocations in murine plasmacytomas involve a chromosome 15 locus at least 72 kb from the c-myc oncogene publication-title: EMBO J. doi: 10.1002/j.1460-2075.1985.tb03682.x – volume: 17 start-page: 1337 year: 2019 ident: 10.1016/j.molcel.2019.12.014_bib55 article-title: Long non-coding RNA PVT1 promotes glioma cell proliferation and invasion by targeting miR-200a publication-title: Exp. Ther. Med. – volume: 2 start-page: e974467 year: 2015 ident: 10.1016/j.molcel.2019.12.014_bib48 article-title: The PVT1-MYC duet in cancer publication-title: Mol. Cell. Oncol. doi: 10.4161/23723556.2014.974467 – volume: 5 start-page: 2845 year: 1986 ident: 10.1016/j.molcel.2019.12.014_bib18 article-title: Chromosome 8 breakpoint far 3′ of the c-myc oncogene in a Burkitt’s lymphoma 2;8 variant translocation is equivalent to the murine pvt-1 locus publication-title: EMBO J. doi: 10.1002/j.1460-2075.1986.tb04578.x – volume: 17 start-page: 10 year: 2011 ident: 10.1016/j.molcel.2019.12.014_bib63 article-title: Cutadapt removes adapter sequences from high-throughput sequencing reads publication-title: EMBnet.journal doi: 10.14806/ej.17.1.200 – volume: 15 start-page: 221 year: 2018 ident: 10.1016/j.molcel.2019.12.014_bib46 article-title: TimeLapse-seq: adding a temporal dimension to RNA sequencing through nucleoside recoding publication-title: Nat. Methods doi: 10.1038/nmeth.4582 – volume: 9 start-page: 998 year: 2014 ident: 10.1016/j.molcel.2019.12.014_bib43 article-title: Frequent coamplification and cooperation between C-MYC and PVT1 oncogenes promote malignant pleural mesothelioma publication-title: J. Thorac. Oncol. doi: 10.1097/JTO.0000000000000202 – volume: 172 start-page: 393 year: 2018 ident: 10.1016/j.molcel.2019.12.014_bib31 article-title: Functional classification and experimental dissection of long noncoding RNAs publication-title: Cell doi: 10.1016/j.cell.2018.01.011 – volume: 137 start-page: 413 year: 2009 ident: 10.1016/j.molcel.2019.12.014_bib51 article-title: Blinded by the light: the growing complexity of p53 publication-title: Cell doi: 10.1016/j.cell.2009.04.037 – volume: 471 start-page: 10 year: 2016 ident: 10.1016/j.molcel.2019.12.014_bib9 article-title: Long non-coding RNA PVT1 and cancer publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2015.12.101 – volume: 8 start-page: 75455 year: 2017 ident: 10.1016/j.molcel.2019.12.014_bib54 article-title: LncRNA PVT1 as an effective biomarker for cancer diagnosis and detection based on transcriptome data and meta-analysis publication-title: Oncotarget doi: 10.18632/oncotarget.20634 – volume: 314 start-page: 740 year: 1985 ident: 10.1016/j.molcel.2019.12.014_bib19 article-title: Murine T lymphomas with retroviral inserts in the chromosomal 15 locus for plasmacytoma variant translocations publication-title: Nature doi: 10.1038/314740a0 – volume: 31 start-page: 166 year: 2015 ident: 10.1016/j.molcel.2019.12.014_bib1 article-title: HTSeq—a Python framework to work with high-throughput sequencing data publication-title: Bioinformatics doi: 10.1093/bioinformatics/btu638 – volume: 25 start-page: 2078 year: 2009 ident: 10.1016/j.molcel.2019.12.014_bib36 article-title: The Sequence Alignment/Map format and SAMtools publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp352 – volume: 151 start-page: 56 year: 2012 ident: 10.1016/j.molcel.2019.12.014_bib59 article-title: Transcriptional amplification in tumor cells with elevated c-Myc publication-title: Cell doi: 10.1016/j.cell.2012.08.026 – volume: 488 start-page: 49 year: 2012 ident: 10.1016/j.molcel.2019.12.014_bib40 article-title: Subgroup-specific structural variation across 1,000 medulloblastoma genomes publication-title: Nature doi: 10.1038/nature11327 – volume: 8 start-page: 113174 year: 2017 ident: 10.1016/j.molcel.2019.12.014_bib58 article-title: Prognostic value of long non-coding RNA PVT1 as a novel biomarker in various cancers: a meta-analysis publication-title: Oncotarget doi: 10.18632/oncotarget.22830 – volume: 14 start-page: 82 year: 2015 ident: 10.1016/j.molcel.2019.12.014_bib30 article-title: Long noncoding RNA PVT1 indicates a poor prognosis of gastric cancer and promotes cell proliferation through epigenetically regulating p15 and p16 publication-title: Mol. Cancer doi: 10.1186/s12943-015-0355-8 – volume: 463 start-page: 297 year: 2008 ident: 10.1016/j.molcel.2019.12.014_bib4 article-title: Combined immunofluorescence, RNA fluorescent in situ hybridization, and DNA fluorescent in situ hybridization to study chromatin changes, transcriptional activity, nuclear organization, and X-chromosome inactivation publication-title: Methods Mol. Biol. doi: 10.1007/978-1-59745-406-3_18 – volume: 15 start-page: 550 year: 2014 ident: 10.1016/j.molcel.2019.12.014_bib64 article-title: Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 publication-title: Genome Biol. doi: 10.1186/s13059-014-0550-8 – volume: 12 start-page: 2357 year: 2016 ident: 10.1016/j.molcel.2019.12.014_bib57 article-title: High expression of lncRNA PVT1 promotes invasion by inducing epithelial-to-mesenchymal transition in esophageal cancer publication-title: Oncol. Lett. doi: 10.3892/ol.2016.5026 – volume: 537 start-page: 239 year: 2016 ident: 10.1016/j.molcel.2019.12.014_bib32 article-title: The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan publication-title: Nature doi: 10.1038/nature19346 – volume: 4 start-page: 1064 year: 2009 ident: 10.1016/j.molcel.2019.12.014_bib13 article-title: Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase publication-title: Nat. Protoc. doi: 10.1038/nprot.2009.95 – volume: 2 start-page: 1722 year: 2007 ident: 10.1016/j.molcel.2019.12.014_bib23 article-title: Quantitative analysis of chromosome conformation capture assays (3C-qPCR) publication-title: Nat. Protoc. doi: 10.1038/nprot.2007.243 – volume: 3 start-page: e03058 year: 2014 ident: 10.1016/j.molcel.2019.12.014_bib3 article-title: Considerations when investigating lncRNA function in vivo publication-title: eLife doi: 10.7554/eLife.03058 – volume: 25 start-page: 1511 year: 2018 ident: 10.1016/j.molcel.2019.12.014_bib14 article-title: Genetic models reveal cis and trans immune-regulatory activities for lincRNA-Cox2 publication-title: Cell Rep. doi: 10.1016/j.celrep.2018.10.027 – volume: 445 start-page: 661 year: 2007 ident: 10.1016/j.molcel.2019.12.014_bib50 article-title: Restoration of p53 function leads to tumour regression in vivo publication-title: Nature doi: 10.1038/nature05541 – volume: 25 start-page: 1105 year: 2009 ident: 10.1016/j.molcel.2019.12.014_bib47 article-title: TopHat: discovering splice junctions with RNA-Seq publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp120 – volume: 33 start-page: 5434 year: 2014 ident: 10.1016/j.molcel.2019.12.014_bib28 article-title: Novel fusion transcripts in human gastric cancer revealed by transcriptome analysis publication-title: Oncogene doi: 10.1038/onc.2013.490 – volume: 106 start-page: 3207 year: 2009 ident: 10.1016/j.molcel.2019.12.014_bib45 article-title: p53 represses c-Myc through induction of the tumor suppressor miR-145 publication-title: Proc. Natl. Acad. Sci. U S A doi: 10.1073/pnas.0808042106 – volume: 23 start-page: 2071 year: 2017 ident: 10.1016/j.molcel.2019.12.014_bib53 article-title: A positive feedback loop of lncRNA-PVT1 and FOXM1 facilitates gastric cancer growth and invasion publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-16-0742 – volume: 173 start-page: 1398 year: 2018 ident: 10.1016/j.molcel.2019.12.014_bib5 article-title: Promoter of lncRNA gene PVT1 is a tumor-suppressor DNA boundary element publication-title: Cell doi: 10.1016/j.cell.2018.03.068 – volume: 1 start-page: 417 year: 2015 ident: 10.1016/j.molcel.2019.12.014_bib37 article-title: The Molecular Signatures Database (MSigDB) hallmark gene set collection publication-title: Cell Syst. doi: 10.1016/j.cels.2015.12.004 – volume: 25 start-page: 114 year: 2018 ident: 10.1016/j.molcel.2019.12.014_bib15 article-title: Cell cycle arrest through indirect transcriptional repression by p53: I have a DREAM publication-title: Cell Death Differ. doi: 10.1038/cdd.2017.172 – volume: 338 start-page: 1435 year: 2012 ident: 10.1016/j.molcel.2019.12.014_bib33 article-title: Epigenetic regulation by long noncoding RNAs publication-title: Science doi: 10.1126/science.1231776 – volume: 33 start-page: 1159 year: 2015 ident: 10.1016/j.molcel.2019.12.014_bib10 article-title: Orthogonal gene knockout and activation with a catalytically active Cas9 nuclease publication-title: Nat. Biotechnol. doi: 10.1038/nbt.3390 – volume: 54 start-page: 777 year: 2014 ident: 10.1016/j.molcel.2019.12.014_bib11 article-title: LincRNA-p21 activates p21 in cis to promote Polycomb target gene expression and to enforce the G1/S checkpoint publication-title: Mol. Cell doi: 10.1016/j.molcel.2014.04.025 – volume: 52 start-page: 802 year: 2013 ident: 10.1016/j.molcel.2019.12.014_bib25 article-title: Genome-wide identification of genes with amplification and/or fusion in small cell lung cancer publication-title: Genes Chromosomes Cancer doi: 10.1002/gcc.22076 – volume: 13 start-page: 7942 year: 1993 ident: 10.1016/j.molcel.2019.12.014_bib35 article-title: Complementation by wild-type p53 of interleukin-6 effects on M1 cells: induction of cell cycle exit and cooperativity with c-myc suppression publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.13.12.7942 – volume: 9 start-page: 1767 year: 1994 ident: 10.1016/j.molcel.2019.12.014_bib6 article-title: p53 dependence of early apoptotic and proliferative responses within the mouse intestinal epithelium following gamma-irradiation publication-title: Oncogene – volume: 26 start-page: 139 year: 2010 ident: 10.1016/j.molcel.2019.12.014_bib44 article-title: edgeR: a Bioconductor package for differential expression analysis of digital gene expression data publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp616 – volume: 9 start-page: 749 year: 2009 ident: 10.1016/j.molcel.2019.12.014_bib34 article-title: The first 30 years of p53: growing ever more complex publication-title: Nat. Rev. Cancer doi: 10.1038/nrc2723 – volume: 468 start-page: 572 year: 2010 ident: 10.1016/j.molcel.2019.12.014_bib17 article-title: Stage-specific sensitivity to p53 restoration during lung cancer progression publication-title: Nature doi: 10.1038/nature09535 – volume: 65 start-page: 10280 year: 2005 ident: 10.1016/j.molcel.2019.12.014_bib27 article-title: The differential effects of mutant p53 alleles on advanced murine lung cancer publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-05-2193 – volume: 1468 start-page: 1 year: 2017 ident: 10.1016/j.molcel.2019.12.014_bib7 article-title: Cellular fractionation and isolation of chromatin-associated RNA publication-title: Methods Mol. Biol. doi: 10.1007/978-1-4939-4035-6_1 – volume: 159 start-page: 440 year: 2014 ident: 10.1016/j.molcel.2019.12.014_bib41 article-title: CRISPR-Cas9 knockin mice for genome editing and cancer modeling publication-title: Cell doi: 10.1016/j.cell.2014.09.014 |
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| SubjectTerms | Animals Carcinogenesis - genetics Cell Line Cell Proliferation Cells, Cultured Chromatin - metabolism Enhancer Elements, Genetic Gene Expression Regulation Humans long noncoding RNA lung cancer Lung Neoplasms - genetics Lung Neoplasms - pathology Mice Mice, Inbred C57BL mouse model of cancer MYC p53 Promoter Regions, Genetic Proto-Oncogene Proteins c-myc - antagonists & inhibitors Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism Pvt1 RNA, Long Noncoding - antagonists & inhibitors RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Stress, Physiological - genetics tumor suppressor Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism |
| Title | p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis |
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