The major histocompatibility complex: a model for understanding graft-versus-host disease

• Published in: Blood Vol. 122; no. 11; pp. 1863 - 1872
• Main Author: Petersdorf, Effie W.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 12.09.2013; American Society of Hematology
• Subjects: Graft vs Host Disease - etiology; Graft vs Host Disease - genetics; Graft vs Host Disease - immunology; Hematologic Neoplasms - genetics; Hematologic Neoplasms - immunology; Hematologic Neoplasms - surgery; Hematopoietic Stem Cell Transplantation - adverse effects; Hematopoietic Stem Cell Transplantation - methods; Histocompatibility - genetics; Histocompatibility - immunology; HLA Antigens - genetics; HLA Antigens - immunology; Humans; Kaplan-Meier Estimate; Major Histocompatibility Complex - genetics; Major Histocompatibility Complex - immunology; Polymorphism, Single Nucleotide; Review

Acute graft-versus-host disease (GVHD) afflicts as much as 80% of all patients who receive an unrelated donor hematopoietic cell transplant (HCT) for the treatment of blood disorders, even with optimal donor HLA matching and use of prophylactic immunosuppressive agents. Of patients who develop acute...