Protective Effects of Glucagon-Like Peptide-1 Analog on Renal Tubular Injury in Mice on High-Fat Diet

• Published in: Cellular physiology and biochemistry Vol. 41; no. 3; pp. 1113 - 1124
• Main Authors: Guo, Honglei, Li, Hongmei, Wang, Bin, Ding, Wei, Ling, Lilu, Yang, Min, Gu, Yong, Niu, Jianying
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 01.01.2017; Cell Physiol Biochem Press GmbH & Co KG
• Subjects: Activating Transcription Factor 4 - genetics; Activating Transcription Factor 4 - metabolism; Angiotensin II - genetics; Angiotensin II - metabolism; Animals; Apoptosis; AT1R; Blood Pressure - drug effects; Body Weight - drug effects; Diabetes; Diet; Diet, High-Fat - adverse effects; Eating - drug effects; Endoplasmic reticulum; Endoplasmic Reticulum Stress - drug effects; ERS; Eukaryotic Initiation Factor-2 - genetics; Eukaryotic Initiation Factor-2 - metabolism; Fatty acids; Gene Expression - drug effects; GLP-1; Glucagon-Like Peptide 1 - analogs & derivatives; Glucagon-Like Peptide 1 - pharmacology; Heat-Shock Proteins - genetics; Heat-Shock Proteins - metabolism; Inflammation; Insulin resistance; Ischemia; Kidney diseases; Kidney Tubules, Proximal - drug effects; Kidney Tubules, Proximal - metabolism; Kidney Tubules, Proximal - pathology; Kinases; Male; Mice; Nephritis - etiology; Nephritis - genetics; Nephritis - pathology; Nephritis - prevention & control; Obesity; Organ Size - drug effects; Original Paper; Oxidative stress; Palmitic Acid - pharmacology; Peptides; Protective Agents - pharmacology; Proteins; Receptor, Angiotensin, Type 1 - genetics; Receptor, Angiotensin, Type 1 - metabolism; Renal tubular; Rodents; Transcription Factor CHOP - genetics; Transcription Factor CHOP - metabolism; Transcription factors; Weight control; United States > US; China; AT1R; GLP-1; Renal tubular; ERS; Apoptosis

Aims: The study aimed to investigate the renoprotective effect of glucagon-like peptide-1 (GLP-1) against renal tubular injury in C57BL/6 mice induced by a high-fat diet (HFD). Methods: Twenty C57BL/6 mice were fed HFD for 12 weeks. Ten of these mice were treated with GLP-1 at 200 µg/kg subcutaneous...