A human breast atlas integrating single-cell proteomics and transcriptomics

• Published in: Developmental cell Vol. 57; no. 11; pp. 1400 - 1420.e7
• Main Authors: Gray, G. Kenneth, Li, Carman Man-Chung, Rosenbluth, Jennifer M., Selfors, Laura M., Girnius, Nomeda, Lin, Jia-Ren, Schackmann, Ron C.J., Goh, Walter L., Moore, Kaitlin, Shapiro, Hana K., Mei, Shaolin, D’Andrea, Kurt, Nathanson, Katherine L., Sorger, Peter K., Santagata, Sandro, Regev, Aviv, Garber, Judy E., Dillon, Deborah A., Brugge, Joan S.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 06.06.2022
• Subjects: aging; Animals; BRCA1; BRCA2; Breast; breast cancer; Breast Neoplasms - genetics; cell state plasticity; CyTOF mass cytometry; Female; Humans; mammary biology; Mammary Glands, Animal; multi-omic single-cell atlas; multiplexed tissue staining; organoids; Pregnancy; Proteomics; scRNA-Seq; Transcriptome - genetics; multiplexed tissue staining; multi-omic single-cell atlas; scRNA-Seq; organoids; breast cancer; mammary biology; CyTOF mass cytometry; aging; BRCA1; BRCA2; cell state plasticity

The breast is a dynamic organ whose response to physiological and pathophysiological conditions alters its disease susceptibility, yet the specific effects of these clinical variables on cell state remain poorly annotated. We present a unified, high-resolution breast atlas by integrating single-cell...