Limited Regeneration Potential with Minimal Epicardial Progenitor Conversions in the Neonatal Mouse Heart after Injury

• Published in: Cell reports (Cambridge) Vol. 28; no. 1; pp. 190 - 201.e3
• Main Authors: Cai, Weibin, Tan, Jing, Yan, Jianyun, Zhang, Lu, Cai, Xiaoqiang, Wang, Haiping, Liu, Fang, Ye, Maoqing, Cai, Chen-Leng
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 02.07.2019; Elsevier
• Subjects: Animals; Animals, Newborn; Cell Differentiation - genetics; Cell Differentiation - physiology; Cell Lineage; cell lineage tracing; Coronary Vessels - cytology; Coronary Vessels - metabolism; Endothelial Cells - cytology; Endothelial Cells - metabolism; epicardial cells; Gene Knock-In Techniques; Heart - physiology; Heart Injuries - genetics; Heart Injuries - metabolism; heart regeneration; Mice; Myocytes, Cardiac - cytology; Myocytes, Cardiac - metabolism; neonatal mouse; Neovascularization, Physiologic; Pericardium - cytology; Pericardium - metabolism; Regeneration - genetics; Regeneration - physiology; Stem Cells - cytology; Stem Cells - metabolism; T-Box Domain Proteins - genetics; T-Box Domain Proteins - metabolism; epicardial cells; cell lineage tracing; neonatal mouse; heart regeneration

The regeneration capacity of neonatal mouse heart is controversial. In addition, whether epicardial cells provide a progenitor pool for de novo heart regeneration is incompletely defined. Following apical resection of the neonatal mouse heart, we observed limited regeneration potential. Fate-mapping...