Aldosterone esters and the heart

• Published in: American journal of hypertension Vol. 14; no. S3; pp. 200S - 205S
• Main Authors: Gomez-Sanchez, Celso E, Foecking, Mark F, Gomez-Sanchez, Elise P
• Format: Journal Article Conference Proceeding
• Language: English
• Published: New York, NY Elsevier Inc 01.06.2001; Oxford University Press; Elsevier Science
• Subjects: Aldosterone; Aldosterone - analogs & derivatives; Aldosterone - metabolism; aldosterone acetate; Animals; Biological and medical sciences; Blood - metabolism; cardiac fibrosis; Cardiology. Vascular system; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Enzyme-Linked Immunosorbent Assay; Esters; Heart; Heart failure, cardiogenic pulmonary edema, cardiac enlargement; Hydrolysis; In Vitro Techniques; Medical sciences; Myocardium - metabolism; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Aldosterone; cardiac fibrosis; aldosterone acetate; Heart; Rat; Pathogenesis; Rodentia; Cardiovascular disease; Ester; Vertebrata; Mammalia; Heart disease; Animal; Fibrosis; Hypertrophy

There are clinical and experimental situations in which symptoms of mineralocorticoid excess are remediable with mineralocorticoid receptor antagonist treatment, in spite of paradoxically low levels of plasma renin and aldosterone. Several decades ago, a factor isolated from the heart was described...