The Effect of Acute Physical Exercise on Natural Killer Cells Populations and Cytokine Levels in Healthy Women

Physical exercise generates a systemic response in the immune system. It has been observed that cell populations respond to exercise stimuli, especially Natural Killer cells, whose number increase within minutes of starting physical exertion. This study aimed to evaluate the acute effect of moderate...

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Published inSports (Basel) Vol. 11; no. 10; p. 189
Main Authors Quintana-Mendias, Estefania, Rodríguez-Villalobos, Judith M, Gastelum-Arellanez, Argel, Cervantes, Natanael, Carrasco-Legleu, Claudia E, Espino-Solis, Gerardo Pavel
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.10.2023
MDPI
Subjects
Antigens
Blood
Body mass index
CD3 antigen
CD56 antigen
Cell activation
Chemokines
Cloning
CXCL10 protein
cytokine profile
Cytokines
Cytotoxicity
Effector cells
Exercise
Flow cytometry
Health aspects
Immune system
Immunology
Interleukin 6
IP-10 protein
Killer cells
Lymphocytes
Lymphocytes T
Monocyte chemoattractant protein 1
Natural Killer cells
Obesity
Overweight
Physical fitness
Physiological research
RANTES
Statistical analysis
Women
Womens health
United States
United States > US
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Abstract Physical exercise generates a systemic response in the immune system. It has been observed that cell populations respond to exercise stimuli, especially Natural Killer cells, whose number increase within minutes of starting physical exertion. This study aimed to evaluate the acute effect of moderate- and high-intensity exercise on immunological markers in healthy women. As specific objectives, the percentages of CD3-CD56+ Natural Killer total cells, CD56brightCD16dim effector subpopulation, CD56dimCD16bright cytotoxic subpopulation, NKG2A inhibition receptor, NKG2D activation receptor, and NKT cells were analyzed. In addition, the levels of the cytokines IL-1β, IL-6, IL-8, IL-10, IL-12p70, and TNF and the chemokines CCL5/RANTES, CXCL9/MIG, CCL2/MCP-1, and CXCL10/IP-10 were also analyzed. Natural Killer total cells showed an increase in their percentage in both exercise protocols (p = 0.001 for the moderate-intensity group and p = 0.023 for the high-intensity group); however, only in the high-intensity exercise session was there an increase in the CD56dimCD16bright cytotoxic subpopulation (p = 0.014), as well as a decrease in CD56brightCD16dim effector subpopulation (p = 0.001) and their NKG2A inhibition receptor (p = 0.043). An increase in IL-6 was observed after the high-intensity exercise session (p = 0.025). Conclusions. Physical exercise influences immunological markers and shows an acute response to moderate- or high-intensity exercise.
AbstractList Physical exercise generates a systemic response in the immune system. It has been observed that cell populations respond to exercise stimuli, especially Natural Killer cells, whose number increase within minutes of starting physical exertion. This study aimed to evaluate the acute effect of moderate- and high-intensity exercise on immunological markers in healthy women. As specific objectives, the percentages of CD3-CD56+ Natural Killer total cells, CD56brightCD16dim effector subpopulation, CD56dimCD16bright cytotoxic subpopulation, NKG2A inhibition receptor, NKG2D activation receptor, and NKT cells were analyzed. In addition, the levels of the cytokines IL-1β, IL-6, IL-8, IL-10, IL-12p70, and TNF and the chemokines CCL5/RANTES, CXCL9/MIG, CCL2/MCP-1, and CXCL10/IP-10 were also analyzed. Natural Killer total cells showed an increase in their percentage in both exercise protocols (p = 0.001 for the moderate-intensity group and p = 0.023 for the high-intensity group); however, only in the high-intensity exercise session was there an increase in the CD56dimCD16bright cytotoxic subpopulation (p = 0.014), as well as a decrease in CD56brightCD16dim effector subpopulation (p = 0.001) and their NKG2A inhibition receptor (p = 0.043). An increase in IL-6 was observed after the high-intensity exercise session (p = 0.025). Conclusions. Physical exercise influences immunological markers and shows an acute response to moderate- or high-intensity exercise.
Physical exercise generates a systemic response in the immune system. It has been observed that cell populations respond to exercise stimuli, especially Natural Killer cells, whose number increase within minutes of starting physical exertion. This study aimed to evaluate the acute effect of moderate- and high-intensity exercise on immunological markers in healthy women. As specific objectives, the percentages of CD3 - CD56 + Natural Killer total cells, CD56 bright CD16 dim effector subpopulation, CD56 dim CD16 bright cytotoxic subpopulation, NKG2A inhibition receptor, NKG2D activation receptor, and NKT cells were analyzed. In addition, the levels of the cytokines IL-1β, IL-6, IL-8, IL-10, IL-12p70, and TNF and the chemokines CCL5/RANTES, CXCL9/MIG, CCL2/MCP-1, and CXCL10/IP-10 were also analyzed. Natural Killer total cells showed an increase in their percentage in both exercise protocols ( p = 0.001 for the moderate-intensity group and p = 0.023 for the high-intensity group); however, only in the high-intensity exercise session was there an increase in the CD56 dim CD16 bright cytotoxic subpopulation ( p = 0.014), as well as a decrease in CD56 bright CD16 dim effector subpopulation ( p = 0.001) and their NKG2A inhibition receptor ( p = 0.043). An increase in IL-6 was observed after the high-intensity exercise session ( p = 0.025). Conclusions. Physical exercise influences immunological markers and shows an acute response to moderate- or high-intensity exercise.
Physical exercise generates a systemic response in the immune system. It has been observed that cell populations respond to exercise stimuli, especially Natural Killer cells, whose number increase within minutes of starting physical exertion. This study aimed to evaluate the acute effect of moderate- and high-intensity exercise on immunological markers in healthy women. As specific objectives, the percentages of CD3[sup.-] CD56[sup.+] Natural Killer total cells, CD56[sup.bright] CD16[sup.dim] effector subpopulation, CD56[sup.dim] CD16[sup.bright] cytotoxic subpopulation, NKG2A inhibition receptor, NKG2D activation receptor, and NKT cells were analyzed. In addition, the levels of the cytokines IL-1β, IL-6, IL-8, IL-10, IL-12p70, and TNF and the chemokines CCL5/RANTES, CXCL9/MIG, CCL2/MCP-1, and CXCL10/IP-10 were also analyzed. Natural Killer total cells showed an increase in their percentage in both exercise protocols (p = 0.001 for the moderate-intensity group and p = 0.023 for the high-intensity group); however, only in the high-intensity exercise session was there an increase in the CD56[sup.dim] CD16[sup.bright] cytotoxic subpopulation (p = 0.014), as well as a decrease in CD56[sup.bright] CD16[sup.dim] effector subpopulation (p = 0.001) and their NKG2A inhibition receptor (p = 0.043). An increase in IL-6 was observed after the high-intensity exercise session (p = 0.025). Conclusions. Physical exercise influences immunological markers and shows an acute response to moderate- or high-intensity exercise.
Audience Academic
Author Rodríguez-Villalobos, Judith M
Carrasco-Legleu, Claudia E
Espino-Solis, Gerardo Pavel
Gastelum-Arellanez, Argel
Quintana-Mendias, Estefania
Cervantes, Natanael
AuthorAffiliation 1 Research Laboratories, Faculty of Physical Culture Sciences, Autonomous University of Chihuahua, Campus II, Periférico de la Juventud y Circuito Universitario S/N. Fracc, Campo Bello 31125, Mexico; esquintana@uach.mx (E.Q.-M.); jurodrig@uach.mx (J.M.R.-V.); ncervantes@uach.mx (N.C.); ccarrasco@uach.mx (C.E.C.-L.)
3 National Laboratory of Flow Cytometry, Faculty of Medicine, and Biomedical Sciences, Autonomous University of Chihuahua, Circuito Universitario s/n, Campus II, Chihuahua 31125, Mexico
2 Departamento de Ciencias Quimico Biologicas, Instituto de Ciencias Biomedicas, Universidad Autonoma de Ciudad Juarez, Av. Benjamín Franklin No. 4650, Zona Pronaf Condominio La Plata, Cd Juárez 32310, Mexico; argel.gastelum@gmail.com
AuthorAffiliation_xml – name: 2 Departamento de Ciencias Quimico Biologicas, Instituto de Ciencias Biomedicas, Universidad Autonoma de Ciudad Juarez, Av. Benjamín Franklin No. 4650, Zona Pronaf Condominio La Plata, Cd Juárez 32310, Mexico; argel.gastelum@gmail.com
– name: 1 Research Laboratories, Faculty of Physical Culture Sciences, Autonomous University of Chihuahua, Campus II, Periférico de la Juventud y Circuito Universitario S/N. Fracc, Campo Bello 31125, Mexico; esquintana@uach.mx (E.Q.-M.); jurodrig@uach.mx (J.M.R.-V.); ncervantes@uach.mx (N.C.); ccarrasco@uach.mx (C.E.C.-L.)
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Snippet Physical exercise generates a systemic response in the immune system. It has been observed that cell populations respond to exercise stimuli, especially...
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StartPage 189
SubjectTerms Antigens
Blood
Body mass index
CD3 antigen
CD56 antigen
Cell activation
Chemokines
Cloning
CXCL10 protein
cytokine profile
Cytokines
Cytotoxicity
Effector cells
Exercise
Flow cytometry
Health aspects
Immune system
Immunology
Interleukin 6
IP-10 protein
Killer cells
Lymphocytes
Lymphocytes T
Monocyte chemoattractant protein 1
Natural Killer cells
Obesity
Overweight
Physical fitness
Physiological research
RANTES
Statistical analysis
Women
Womens health
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Title The Effect of Acute Physical Exercise on Natural Killer Cells Populations and Cytokine Levels in Healthy Women
URI https://www.proquest.com/docview/2882818459
https://search.proquest.com/docview/2883573501
https://pubmed.ncbi.nlm.nih.gov/PMC10611276
https://doaj.org/article/bcadd345da6d41c5a422cfc1e4657f5f
Volume 11
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