Platelets mediate increased endothelium permeability in dengue through NLRP3-inflammasome activation

• Published in: Blood Vol. 122; no. 20; pp. 3405 - 3414
• Main Authors: Hottz, Eugenio D., Lopes, Juliana F., Freitas, Carla, Valls-de-Souza, Rogério, Oliveira, Marcus F., Bozza, Marcelo T., Da Poian, Andrea T., Weyrich, Andrew S., Zimmerman, Guy A., Bozza, Fernando A., Bozza, Patricia T.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 14.11.2013; American Society of Hematology
• Subjects: Adult; Blood Platelets - drug effects; Blood Platelets - metabolism; Blood Platelets - ultrastructure; Capillary Permeability - physiology; Carrier Proteins - physiology; Caspase 1 - physiology; Cell-Derived Microparticles - metabolism; Dengue - blood; Dengue - physiopathology; Endothelium, Vascular - physiopathology; Female; Flow Cytometry; Gene Expression Regulation - drug effects; Humans; Imidazoles - pharmacology; Indoles - pharmacology; Inflammasomes - physiology; Interleukin-1beta - biosynthesis; Interleukin-1beta - metabolism; Male; Mitochondria - metabolism; NLR Family, Pyrin Domain-Containing 3 Protein; Organophosphorus Compounds - pharmacology; Piperidines - pharmacology; Platelet Activation; Plenary Paper; Reactive Oxygen Species - metabolism; Tosylphenylalanyl Chloromethyl Ketone - analogs & derivatives; Tosylphenylalanyl Chloromethyl Ketone - pharmacology; Up-Regulation - drug effects

Dengue is the most frequent hemorrhagic viral disease and re-emergent infection in the world. Although thrombocytopenia is characteristically observed in mild and severe forms of dengue, the role of platelet activation in dengue pathogenesis has not been fully elucidated. We hypothesize that platele...