Promoter-Enhancer Communication Occurs Primarily within Insulated Neighborhoods

• Published in: Molecular cell Vol. 73; no. 2; pp. 250 - 263.e5
• Main Authors: Sun, Fei, Chronis, Constantinos, Kronenberg, Michael, Chen, Xiao-Fen, Su, Trent, Lay, Fides D., Plath, Kathrin, Kurdistani, Siavash K., Carey, Michael F.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 17.01.2019
• Subjects: Animals; Binding Sites; CCCTC-Binding Factor - genetics; CCCTC-Binding Factor - metabolism; Cell Cycle Proteins - genetics; Cell Cycle Proteins - metabolism; Cell Line; chromatin looping; Chromosomal Proteins, Non-Histone - genetics; Chromosomal Proteins, Non-Histone - metabolism; Chromosomes, Mammalian; Cohesins; Databases, Genetic; Down-Regulation; enhancer; Enhancer Elements, Genetic; Esrrb; insulated neighborhood; Insulator Elements; Mice; Mouse Embryonic Stem Cells - physiology; promoter; Promoter Regions, Genetic; Protein Binding; Receptors, Estrogen - genetics; Receptors, Estrogen - metabolism; RNA, Messenger - biosynthesis; RNA, Messenger - genetics; transcription; Transcription, Genetic; enhancer; promoter; chromatin looping; transcription; Esrrb; insulated neighborhood

Metazoan chromosomes are sequentially partitioned into topologically associating domains (TADs) and then into smaller sub-domains. One class of sub-domains, insulated neighborhoods, are proposed to spatially sequester and insulate the enclosed genes through self-association and chromatin looping. Ho...