SARS-CoV-2 spike promotes inflammation and apoptosis through autophagy by ROS-suppressed PI3K/AKT/mTOR signaling

• Published in: Biochimica et biophysica acta. Molecular basis of disease Vol. 1867; no. 12; p. 166260
• Main Authors: Li, Fei, Li, Jingyao, Wang, Pei-Hui, Yang, Nanyan, Huang, Junyu, Ou, Jinxin, Xu, Ting, Zhao, Xin, Liu, Taoshu, Huang, Xueying, Wang, Qinghuan, Li, Miao, Yang, Le, Lin, Yunchen, Cai, Ying, Chen, Haisheng, Zhang, Qing
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2021; The Author(s). Published by Elsevier B.V
• Subjects: Animals; Apoptosis; Apoptosis - immunology; Autophagy; Autophagy - physiology; Cell Line; Chlorocebus aethiops; COVID-19 - metabolism; Endothelial Cells - metabolism; HEK293 Cells; Humans; Inflammation; Inflammation - immunology; Inflammation - metabolism; Phosphatidylinositol 3-Kinases - metabolism; Proto-Oncogene Proteins c-akt - metabolism; Reactive oxygen species; Reactive Oxygen Species - metabolism; SARS-CoV-2; SARS-CoV-2 - pathogenicity; Signal Transduction - immunology; Spike Glycoprotein, Coronavirus - immunology; Spike Glycoprotein, Coronavirus - metabolism; TOR Serine-Threonine Kinases - metabolism; Vero Cells; Reactive oxygen species; IL; Inflammation; MERS-CoV; Co-IP; Autophagy; COVID-19; ACE2; SARS-CoV-2; DEGs; TUNEL; TNF-α; RT-PCR; ROS; KEGG; 3-MA; Apoptosis; ELISA

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection-induced inflammatory responses are largely responsible for the death of novel coronavirus disease 2019 (COVID-19) patients. However, the mechanism by which SARS-CoV-2 triggers inflammatory responses remains unclear. Here, we aime...