SARS-CoV-2 spike promotes inflammation and apoptosis through autophagy by ROS-suppressed PI3K/AKT/mTOR signaling - Li, Fei; Li, Jingyao; Wang, Pei-Hui; Yang, Nanyan; Huang, Junyu; Ou, Jinxin; Xu, Ting; Zhao, Xin; Liu, Taoshu; Huang, Xueying; Wang, Qinghuan; Li, Miao; et al. (Biochimica et biophysica acta. Molecular basis of disease, 2021)
Keywords: Animals; Apoptosis; Apoptosis - immunology; Autophagy; Autophagy - physiology; Cell Line; Chlorocebus aethiops; COVID-19 - metabolism; Endothelial Cells - metabolism; HEK293 Cells; Humans; Inflammation; Inflammation - immunology; Inflammation - metabolism; Phosphatidylinositol 3-Kinases - metabolism; Proto-Oncogene Proteins c-akt - metabolism; Reactive oxygen species; Reactive Oxygen Species - metabolism; SARS-CoV-2; SARS-CoV-2 - pathogenicity; Signal Transduction - immunology; Spike Glycoprotein, Coronavirus - immunology; Spike Glycoprotein, Coronavirus - metabolism; TOR Serine-Threonine Kinases - metabolism; Vero Cells; Reactive oxygen species; IL; Inflammation; MERS-CoV; Co-IP; Autophagy; COVID-19; ACE2; SARS-CoV-2; DEGs; TUNEL; TNF-α; RT-PCR; ROS; KEGG; 3-MA; Apoptosis; ELISA