Interstitial tumor-associated macrophages combined with tumor-derived colony-stimulating factor-1 and interleukin-6, a novel prognostic biomarker in non–small cell lung cancer

• Published in: The Journal of thoracic and cardiovascular surgery Vol. 148; no. 4; pp. 1208 - 1216.e2
• Main Authors: Pei, Bao-xiang, MD, Sun, Bing-sheng, MD, PhD, Zhang, Zhen-fa, MD, PhD, Wang, An-lei, MD, Ren, Peng, MD, PhD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2014
• Subjects: Aged; Biomarkers, Tumor - metabolism; Carcinoma, Non-Small-Cell Lung - metabolism; Carcinoma, Non-Small-Cell Lung - pathology; Cardiothoracic Surgery; Female; Humans; Immunoenzyme Techniques; Interleukin-6 - metabolism; Lung Neoplasms - metabolism; Lung Neoplasms - pathology; Macrophage Colony-Stimulating Factor - metabolism; Macrophages, Alveolar - metabolism; Male; Middle Aged; Prognosis; Risk Factors; Tissue Array Analysis; TAM; NSCLC; OS; tissue microarray; colony-stimulating factor-1; non–small cell lung cancer; tumor-associated macrophage; TMA; +; positive; CSF-1; IL-6; interleukin-6; DFS; 10.4; 11.3; −; negative; 10.2; disease-free survival; 10.1; overall survival

Objectives Recent experimental evidence has indicated that interstitial tumor-associated macrophages (TAMs), tumor-derived macrophage colony-stimulating factor (also known as CSF-1), and interleukin-6 (IL-6) interact in the pathogenesis of malignant epithelial tumors, including lung cancer. The pres...