Diagnostic Value of Salivary Amino Acid Levels in Cancer

• Published in: Metabolites Vol. 13; no. 8; p. 950
• Main Authors: Bel’skaya, Lyudmila V, Sarf, Elena A, Loginova, Alexandra I
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.08.2023; MDPI
• Subjects: Algorithms; Amino acid sequence; Amino acids; Breast cancer; Cancer; Chromatography; Diagnosis; Discriminant analysis; Gastric cancer; Glioblastoma; Health aspects; Isoleucine; Liver cancer; Lung cancer; Metabolism; Metabolites; metabolome; Nanoparticles; NMR; Nuclear magnetic resonance; Oncology, Experimental; Oral cancer; Pancreatic cancer; Proteins; Review; Saliva; Salivary glands; secretions; Thyroid cancer; Thyroid gland; Valine; Russia
• ISSN: 2218-1989; 2218-1989
• DOI: 10.3390/metabo13080950

This review analyzed 21 scientific papers on the determination of amino acids in various types of cancer in saliva. Most of the studies are on oral cancer (8/21), breast cancer (4/21), gastric cancer (3/21), lung cancer (2/21), glioblastoma (2/21) and one study on colorectal, pancreatic, thyroid and liver cancer. The amino acids alanine, valine, phenylalanine, leucine and isoleucine play a leading role in the diagnosis of cancer via the saliva. In an independent version, amino acids are rarely used; the authors combine either amino acids with each other or with other metabolites, which makes it possible to obtain high values of sensitivity and specificity. Nevertheless, a logical and complete substantiation of the changes in saliva occurring in cancer, including changes in salivary amino acid levels, has not yet been formed, which makes it important to continue research in this direction.