Naive-like ESRRB+ iPSCs with the Capacity for Rapid Neural Differentiation

• Published in: Stem cell reports Vol. 9; no. 6; pp. 1825 - 1838
• Main Authors: Kisa, Fumihiko, Shiozawa, Seiji, Oda, Keisuke, Yoshimatsu, Sho, Nakamura, Mari, Koya, Ikuko, Kawai, Kenji, Suzuki, Sadafumi, Okano, Hideyuki
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 12.12.2017; Elsevier
• Subjects: human iPSC; naive pluripotency; neural differentiation; reprogramming; reprogramming; human iPSC; naive pluripotency; neural differentiation

Several groups have reported the existence of a form of pluripotency that resembles that of mouse embryonic stem cells (mESCs), i.e., a naive state, in human pluripotent stem cells; however, the characteristics vary between reports. The nuclear receptor ESRRB is expressed in mESCs and plays a signif...