Naive-like ESRRB+ iPSCs with the Capacity for Rapid Neural Differentiation
Several groups have reported the existence of a form of pluripotency that resembles that of mouse embryonic stem cells (mESCs), i.e., a naive state, in human pluripotent stem cells; however, the characteristics vary between reports. The nuclear receptor ESRRB is expressed in mESCs and plays a signif...
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Published in | Stem cell reports Vol. 9; no. 6; pp. 1825 - 1838 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
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Elsevier Inc
12.12.2017
Elsevier |
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Abstract | Several groups have reported the existence of a form of pluripotency that resembles that of mouse embryonic stem cells (mESCs), i.e., a naive state, in human pluripotent stem cells; however, the characteristics vary between reports. The nuclear receptor ESRRB is expressed in mESCs and plays a significant role in their self-renewal, but its expression has not been observed in most naive-like human induced pluripotent stem cells (hiPSCs). In this study, we modified several methods for converting hiPSCs into a naive state through the transgenic expression of several reprogramming factors. The resulting cells express the components of the core transcriptional network of mESCs, including ESRRB, at high levels, which suggests the existence of naive-state hiPSCs that are similar to mESCs. We also demonstrate that these cells differentiate more readily into neural cells than do conventional hiPSCs. These features may be beneficial for their use in disease modeling and regenerative medicine.
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•Induction methods for human naive pluripotent stem cells were optimized•hiPSCs were reprogrammed to a naive-like state with six transcription factors•The resulting naive-like hiPSCs expressed naive state-related genes, including ESRRB•The naive-like hiPSCs differentiated readily into neural and glial cells
Kisa et al. modified several methods for converting human induced pluripotent stem cells (hiPSCs) into a naive state, a form of pluripotency that exists in mouse embryonic stem cells (ESCs). Converted cells express components of the core transcriptional network upregulated in mouse ESCs, including ESRRB. They also show that these cells differentiate more readily into neural cells than do conventional hiPSCs. |
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AbstractList | Several groups have reported the existence of a form of pluripotency that resembles that of mouse embryonic stem cells (mESCs), i.e., a naive state, in human pluripotent stem cells; however, the characteristics vary between reports. The nuclear receptor ESRRB is expressed in mESCs and plays a significant role in their self-renewal, but its expression has not been observed in most naive-like human induced pluripotent stem cells (hiPSCs). In this study, we modified several methods for converting hiPSCs into a naive state through the transgenic expression of several reprogramming factors. The resulting cells express the components of the core transcriptional network of mESCs, including ESRRB, at high levels, which suggests the existence of naive-state hiPSCs that are similar to mESCs. We also demonstrate that these cells differentiate more readily into neural cells than do conventional hiPSCs. These features may be beneficial for their use in disease modeling and regenerative medicine. Several groups have reported the existence of a form of pluripotency that resembles that of mouse embryonic stem cells (mESCs), i.e., a naive state, in human pluripotent stem cells; however, the characteristics vary between reports. The nuclear receptor ESRRB is expressed in mESCs and plays a significant role in their self-renewal, but its expression has not been observed in most naive-like human induced pluripotent stem cells (hiPSCs). In this study, we modified several methods for converting hiPSCs into a naive state through the transgenic expression of several reprogramming factors. The resulting cells express the components of the core transcriptional network of mESCs, including ESRRB, at high levels, which suggests the existence of naive-state hiPSCs that are similar to mESCs. We also demonstrate that these cells differentiate more readily into neural cells than do conventional hiPSCs. These features may be beneficial for their use in disease modeling and regenerative medicine. [Display omitted] •Induction methods for human naive pluripotent stem cells were optimized•hiPSCs were reprogrammed to a naive-like state with six transcription factors•The resulting naive-like hiPSCs expressed naive state-related genes, including ESRRB•The naive-like hiPSCs differentiated readily into neural and glial cells Kisa et al. modified several methods for converting human induced pluripotent stem cells (hiPSCs) into a naive state, a form of pluripotency that exists in mouse embryonic stem cells (ESCs). Converted cells express components of the core transcriptional network upregulated in mouse ESCs, including ESRRB. They also show that these cells differentiate more readily into neural cells than do conventional hiPSCs. Several groups have reported the existence of a form of pluripotency that resembles that of mouse embryonic stem cells (mESCs), i.e., a naive state, in human pluripotent stem cells; however, the characteristics vary between reports. The nuclear receptor ESRRB is expressed in mESCs and plays a significant role in their self-renewal, but its expression has not been observed in most naive-like human induced pluripotent stem cells (hiPSCs). In this study, we modified several methods for converting hiPSCs into a naive state through the transgenic expression of several reprogramming factors. The resulting cells express the components of the core transcriptional network of mESCs, including ESRRB, at high levels, which suggests the existence of naive-state hiPSCs that are similar to mESCs. We also demonstrate that these cells differentiate more readily into neural cells than do conventional hiPSCs. These features may be beneficial for their use in disease modeling and regenerative medicine. : Kisa et al. modified several methods for converting human induced pluripotent stem cells (hiPSCs) into a naive state, a form of pluripotency that exists in mouse embryonic stem cells (ESCs). Converted cells express components of the core transcriptional network upregulated in mouse ESCs, including ESRRB. They also show that these cells differentiate more readily into neural cells than do conventional hiPSCs. Keywords: naive pluripotency, human iPSC, reprogramming, neural differentiation Several groups have reported the existence of a form of pluripotency that resembles that of mouse embryonic stem cells (mESCs), i.e., a naive state, in human pluripotent stem cells; however, the characteristics vary between reports. The nuclear receptor ESRRB is expressed in mESCs and plays a significant role in their self-renewal, but its expression has not been observed in most naive-like human induced pluripotent stem cells (hiPSCs). In this study, we modified several methods for converting hiPSCs into a naive state through the transgenic expression of several reprogramming factors. The resulting cells express the components of the core transcriptional network of mESCs, including ESRRB, at high levels, which suggests the existence of naive-state hiPSCs that are similar to mESCs. We also demonstrate that these cells differentiate more readily into neural cells than do conventional hiPSCs. These features may be beneficial for their use in disease modeling and regenerative medicine. • Induction methods for human naive pluripotent stem cells were optimized • hiPSCs were reprogrammed to a naive-like state with six transcription factors • The resulting naive-like hiPSCs expressed naive state-related genes, including ESRRB • The naive-like hiPSCs differentiated readily into neural and glial cells Kisa et al. modified several methods for converting human induced pluripotent stem cells (hiPSCs) into a naive state, a form of pluripotency that exists in mouse embryonic stem cells (ESCs). Converted cells express components of the core transcriptional network upregulated in mouse ESCs, including ESRRB. They also show that these cells differentiate more readily into neural cells than do conventional hiPSCs. |
Author | Koya, Ikuko Yoshimatsu, Sho Shiozawa, Seiji Nakamura, Mari Oda, Keisuke Kawai, Kenji Kisa, Fumihiko Suzuki, Sadafumi Okano, Hideyuki |
AuthorAffiliation | 1 Department of Physiology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan 2 Discovery Research Laboratories I, Minase Research Institute, Ono Pharmaceutical Co., Ltd., 3-1-1 Sakurai, Shimamoto, Mishima, Osaka 618-8585, Japan 3 Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan 4 Pathological Analysis Center, Central Institute for Experimental Animals, 3-25-12 Tonomachi, Kawasaki, Kanagawa 210-0821, Japan |
AuthorAffiliation_xml | – name: 2 Discovery Research Laboratories I, Minase Research Institute, Ono Pharmaceutical Co., Ltd., 3-1-1 Sakurai, Shimamoto, Mishima, Osaka 618-8585, Japan – name: 4 Pathological Analysis Center, Central Institute for Experimental Animals, 3-25-12 Tonomachi, Kawasaki, Kanagawa 210-0821, Japan – name: 1 Department of Physiology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan – name: 3 Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan |
Author_xml | – sequence: 1 givenname: Fumihiko surname: Kisa fullname: Kisa, Fumihiko organization: Department of Physiology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan – sequence: 2 givenname: Seiji surname: Shiozawa fullname: Shiozawa, Seiji organization: Department of Physiology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan – sequence: 3 givenname: Keisuke surname: Oda fullname: Oda, Keisuke organization: Department of Physiology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan – sequence: 4 givenname: Sho surname: Yoshimatsu fullname: Yoshimatsu, Sho organization: Department of Physiology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan – sequence: 5 givenname: Mari surname: Nakamura fullname: Nakamura, Mari organization: Department of Physiology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan – sequence: 6 givenname: Ikuko surname: Koya fullname: Koya, Ikuko organization: Department of Physiology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan – sequence: 7 givenname: Kenji surname: Kawai fullname: Kawai, Kenji organization: Pathological Analysis Center, Central Institute for Experimental Animals, 3-25-12 Tonomachi, Kawasaki, Kanagawa 210-0821, Japan – sequence: 8 givenname: Sadafumi surname: Suzuki fullname: Suzuki, Sadafumi organization: Department of Physiology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan – sequence: 9 givenname: Hideyuki surname: Okano fullname: Okano, Hideyuki email: hidokano@a2.keio.jp organization: Department of Physiology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29129686$$D View this record in MEDLINE/PubMed |
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CitedBy_id | crossref_primary_10_1016_j_celrep_2023_112379 crossref_primary_10_1089_scd_2019_0259 crossref_primary_10_1111_gtc_13000 crossref_primary_10_1016_j_neures_2019_09_005 crossref_primary_10_1093_nar_gkac755 crossref_primary_10_1016_j_stemcr_2021_03_002 crossref_primary_10_1016_j_envpol_2022_120849 crossref_primary_10_1016_j_yexcr_2020_111924 crossref_primary_10_3389_fcell_2021_637309 crossref_primary_10_3389_fvets_2022_989670 crossref_primary_10_1016_j_bbrc_2019_05_175 crossref_primary_10_1016_j_stem_2019_05_001 |
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Keywords | reprogramming human iPSC naive pluripotency neural differentiation |
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Title | Naive-like ESRRB+ iPSCs with the Capacity for Rapid Neural Differentiation |
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