Built to last: lysosome remodeling and repair in health and disease

• Published in: Trends in cell biology Vol. 32; no. 7; pp. 597 - 610
• Main Authors: Zoncu, Roberto, Perera, Rushika M.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.07.2022; Elsevier BV
• Subjects: cancer; Catabolism; Damage accumulation; Humans; infection; lysosome; Lysosomes; Lysosomes - metabolism; membrane damage; Molecular modelling; Neoplasms - pathology; Neurodegeneration; Pathogens; Repair; neurodegeneration; repair; infection; cancer; membrane damage; lysosome

Lysosomes play major roles in growth regulation and catabolism and are recognized as critical mediators of cellular remodeling. An emerging theme is how the lysosome is itself subjected to extensive remodeling in order to perform specific tasks that meet the changing demands of the cell. Accordingly...