The role of galectin-3 and galectin-3–binding protein in venous thrombosis

• Published in: Blood Vol. 125; no. 11; pp. 1813 - 1821
• Main Authors: DeRoo, Elise P., Wrobleski, Shirley K., Shea, Evelyn M., Al-Khalil, Ramsey K., Hawley, Angela E., Henke, Peter K., Myers, Daniel D., Wakefield, Thomas W., Diaz, Jose A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 12.03.2015; American Society of Hematology
• Subjects: Animals; Antigens, Neoplasm - blood; Biomarkers - blood; Biomarkers, Tumor - blood; Blood Platelets - metabolism; Carrier Proteins - blood; Cell Movement; Chemokine CCL2 - metabolism; Disease Models, Animal; Endothelial Cells - metabolism; Erythrocytes - metabolism; Galectin 3 - deficiency; Galectin 3 - genetics; Galectin 3 - metabolism; Glycoproteins - blood; Glycoproteins - metabolism; Humans; Interleukin-6 - deficiency; Interleukin-6 - genetics; Interleukin-6 - metabolism; Leukocytes - metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; Recombinant Proteins - blood; Recombinant Proteins - genetics; Recombinant Proteins - metabolism; RNA, Messenger - genetics; RNA, Messenger - metabolism; Thrombosis and Hemostasis; Venous Thrombosis - blood; Venous Thrombosis - etiology; Venous Thrombosis - metabolism

Galectin-3–binding protein (gal3bp) and its receptor/ligand, galectin-3 (gal3), are secreted proteins that initiate signaling cascades in several diseases, and recent human proteomic data suggest they may play a role in venous thrombosis (VT). We hypothesized that gal3bp and gal3 may promote VT. Usi...