Understanding the SARS-CoV-2 Virus Neutralizing Antibody Response: Lessons to Be Learned from HIV and Respiratory Syncytial Virus

• Published in: Viruses Vol. 15; no. 2; p. 504
• Main Authors: Dimmock, Nigel J., Easton, Andrew J.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 11.02.2023; MDPI
• Subjects: Antibodies; Antibodies, Neutralizing; antibody formation; Antibody response; Comparative analysis; COVID-19; Epitope mapping; epitopes; Health aspects; HIV; HIV Infections; HIV-1; host-pathogen relationships; Human immunodeficiency virus; Human immunodeficiency virus 1; human infection; Humans; Immune response; Infections; Influenza; longevity; mRNA vaccines; neutralization; neutralizing antibody; pandemic; Pandemics; Pathogens; Peptide mapping; Physiological aspects; Protein folding; Proteins; Quantitation; repeated infection; Respiratory syncytial virus; Respiratory Syncytial Virus, Human; Review; RSV; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Trimers; Vaccination; Viral antibodies; Viral envelope proteins; virion; Virions; Viruses; United Kingdom; HIV-1; SARS-CoV-2; RSV; analysis of serum antibody specificity; neutralization assay; neutralizing antibody; epitope specificity; monoclonal antibody; repeated infection; human infection

The SARS-CoV-2 pandemic commenced in 2019 and is still ongoing. Neither infection nor vaccination give long-lasting immunity and, here, in an attempt to understand why this might be, we have compared the neutralizing antibody responses to SARS-CoV-2 with those specific for human immunodeficiency vir...