Targeting smooth muscle cell phenotypic switching in vascular disease

• Published in: JVS-vascular science Vol. 2; pp. 79 - 94
• Main Authors: Chakraborty, Raja, Chatterjee, Payel, Dave, Jui M., Ostriker, Allison C., Greif, Daniel M., Rzucidlo, Eva M., Martin, Kathleen A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2021; Elsevier
• Subjects: Atherosclerosis; Differentiation; Intimal hyperplasia; Phenotypic modulation; Restenosis; Smooth muscle; Restenosis; Smooth muscle; Differentiation; Phenotypic modulation; Intimal hyperplasia; Atherosclerosis

The phenotypic plasticity of vascular smooth muscle cells (VSMCs) is central to vessel growth and remodeling, but also contributes to cardiovascular pathologies. New technologies including fate mapping, single cell transcriptomics, and genetic and pharmacologic inhibitors have provided fundamental n...