Rationally optimized generation of integrated Escherichia coli with stable and high yield lycopene biosynthesis from heterologous mevalonate (MVA) and lycopene expression pathways

• Published in: Synthetic and systems biotechnology Vol. 6; no. 2; pp. 85 - 94
• Main Authors: Hussain, Muhammad Hammad, Hong, Qi, Zaman, Waqas Qamar, Mohsin, Ali, Wei, Yanlong, Zhang, Ning, Fang, Hongqing, Wang, Zejian, Hang, Haifeng, Zhuang, Yingping, Guo, Meijin
• Format: Journal Article
• Language: English
• Published: China Elsevier B.V 01.06.2021; KeAi Publishing; KeAi Communications Co., Ltd
• Subjects: Escherichia coli; Fermentation; Integrated MVA pathway; Lycopene biosynthesis; Rational model of expression pathways; Integrated MVA pathway; Lycopene biosynthesis; Rational model of expression pathways; Fermentation; MVA pathway; Escherichia coli; MVA pathway, Mevalonate pathway

The stability and high productivity of heterogeneous terpenoid production in Escherichia coli expression system is one of the most key issues for its large scale industrialization. In the current study on taking lycopene biosynthesis as an example, an integrated Escherichia coli system has been gene...