White matter brain aging in relationship to schizophrenia and its cognitive deficit

• Published in: Schizophrenia research Vol. 230; pp. 9 - 16
• Main Authors: Wang, Jingtao, Kochunov, Peter, Sampath, Hemalatha, Hatch, Kathryn S., Ryan, Meghann C., Xue, Fuzhong, Neda, Jahanshad, Paul, Thompson, Hahn, Britta, Gold, James, Waltz, James, Hong, L. Elliot, Chen, Shuo
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.2021
• Subjects: Aging; Anisotropy; Brain - diagnostic imaging; BrainAGE; Cognition; Cognitive performance; Diffusion Tensor Imaging; Humans; Prediction; Schizophrenia; Schizophrenia - complications; Schizophrenia - diagnostic imaging; White matter; White Matter - diagnostic imaging; Schizophrenia; Cognitive performance; BrainAGE; White matter; Prediction; Diffusion tensor imaging

We hypothesized that cerebral white matter deficits in schizophrenia (SZ) are driven in part by accelerated white matter aging and are associated with cognitive deficits. We used a machine learning model to predict individual age from diffusion tensor imaging features and calculated the delta age (Δ...