The 3p21.31 genetic locus promotes progression to type 1 diabetes through the CCR2/CCL2 pathway

• Published in: Journal of translational autoimmunity (Online) Vol. 4; p. 100127
• Main Authors: Tran, Paul MH, Purohit, Sharad, Kim, Eileen, bin Satter, Khaled, Hopkins, Diane, Waugh, Kathleen, Dong, Fran, Onengut-Gumuscu, Suna, Rich, Stephen S., Rewers, Marian, She, Jin-Xiong
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2021; Elsevier
• Subjects: Autoimmune; CCL2; CCR2; DAISY; Fine mapping; MCP1; Research paper; T1D; MCP1; T1D; Fine mapping; CCL2; Autoimmune; DAISY; CCR2

Multiple cross-sectional and longitudinal studies have shown that serum levels of the chemokine ligand 2 (CCL-2) are associated with type 1 diabetes (T1D), although the direction of effect differs. We assessed CCL-2 serum levels in a longitudinal cohort to clarify this association, combined with gen...