Construction of a combinatorial pipeline using two somatic variant  calling  methods  for whole exome sequence data of gastric cancer

• Published in: The Journal of Medical Investigation Vol. 64; no. 3.4; pp. 233 - 240
• Main Authors: Kohmoto, Tomohiro, Masuda, Kiyoshi, Naruto, Takuya, Tange, Shoichiro, Shoda, Katsutoshi, Hamada, Junichi, Saito, Masako, Ichikawa, Daisuke, Tajima, Atsushi, Otsuji, Eigo, Imoto, Issei
• Format: Journal Article
• Language: English
• Published: Japan The University of Tokushima Faculty of Medicine 2017
• Subjects: Aged; Aged, 80 and over; Algorithms; Exome; Female; Gastric cancer; High-Throughput Nucleotide Sequencing; Humans; Male; Middle Aged; Mutation; somatic mutations; Stomach Neoplasms - genetics; variant calling algorithms; somatic mutations; exome; Gastric cancer; variant calling algorithms

High-throughput next-generation sequencing is a powerful tool to identify the genotypic landscapes of somatic variants and therapeutic targets in various cancers including gastric cancer, forming the basis for personalized medicine in the clinical setting. Although the advent of many computational a...