Glioblastoma and endothelial cells cross-talk, mediated by SDF-1, enhances tumour invasion and endothelial proliferation by increasing expression of cathepsins B, S, and MMP-9

• Published in: Cancer letters Vol. 289; no. 1; pp. 53 - 61
• Main Authors: Kenig, Saša, Alonso, María Beatriz Durán, Mueller, Margareta M., Lah, Tamara T.
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.03.2010; Elsevier Limited
• Subjects: Angiogenesis; Base Sequence; Cancer; Cathepsin B - metabolism; Cathepsins - metabolism; Cell adhesion & migration; Cell culture; Cell Line, Tumor; Cell Proliferation - drug effects; Cells, Cultured; Chemokine CXCL12 - metabolism; Chemokines (CXCL12/SDF-1); Cysteine cathepsins; Endothelial Cells - cytology; Endothelial Cells - drug effects; Endothelial Cells - pathology; Enzyme-Linked Immunosorbent Assay; Enzymes; Gene expression; Gene Expression Regulation, Enzymologic; Glioblastoma - physiopathology; Glioblastoma invasion; Hematology, Oncology and Palliative Medicine; Humans; Matrix metalloproteases; Matrix Metalloproteinase 9 - metabolism; Molecular Sequence Data; Neoplasm Invasiveness; Paracrine Communication; Protease Inhibitors - pharmacology; Studies; Tumors; Up-Regulation; HIF; VEGF; SDF-1; Glioblastoma invasion; MIP1α; NGF; G-CSF; bFGF; Adhesion molecules: NCAM; Angiogenesis; Chemokines (CXCL12/SDF-1); GBM; Matrix metalloproteases; Cysteine cathepsins; GM-CSF; SF/HGF; TGFβ; Proteases and proteins: MMP; GAPDH; Cytokines: MCP-1; GF; TIMP; stromal-derived factor-1; transforming growth factor β; neural cell adhesion molecule; basic fibroblast growth factor; granulocyte-colony-stimulating factor; monocyte chemotactic protein-1; nerve growth factor; tissue inhibitor of metalloproteinases; growth factors; glyceraldehydes 3-phosphate dehydrogenise; scatter factor/hepatocyte growth factor; glioblastoma; vascular endothelial growth factor; hypoxia induced factor; granulocyte-macrophage colony-stimulating factor; matrix metalloproteinase; macrophage inflammatory protein 1alpha

Malignant glioma is characterized by rapid proliferation, high invasiveness into the surrounding brain and increased vascularity. The aim of the study was to explain the observation that glioblastoma invasion often occurs along existing vasculature, suggesting interactions between the two types of c...