Glioblastoma and endothelial cells cross-talk, mediated by SDF-1, enhances tumour invasion and endothelial proliferation by increasing expression of cathepsins B, S, and MMP-9 - Kenig, Saša; Alonso, María Beatriz Durán; Mueller, Margareta M.; Lah, Tamara T. (Cancer letters, 2010)
Keywords: Angiogenesis; Base Sequence; Cancer; Cathepsin B - metabolism; Cathepsins - metabolism; Cell adhesion & migration; Cell culture; Cell Line, Tumor; Cell Proliferation - drug effects; Cells, Cultured; Chemokine CXCL12 - metabolism; Chemokines (CXCL12/SDF-1); Cysteine cathepsins; Endothelial Cells - cytology; Endothelial Cells - drug effects; Endothelial Cells - pathology; Enzyme-Linked Immunosorbent Assay; Enzymes; Gene expression; Gene Expression Regulation, Enzymologic; Glioblastoma - physiopathology; Glioblastoma invasion; Hematology, Oncology and Palliative Medicine; Humans; Matrix metalloproteases; Matrix Metalloproteinase 9 - metabolism; Molecular Sequence Data; Neoplasm Invasiveness; Paracrine Communication; Protease Inhibitors - pharmacology; Studies; Tumors; Up-Regulation; HIF; VEGF; SDF-1; Glioblastoma invasion; MIP1α; NGF; G-CSF; bFGF; Adhesion molecules: NCAM; Angiogenesis; Chemokines (CXCL12/SDF-1); GBM; Matrix metalloproteases; Cysteine cathepsins; GM-CSF; SF/HGF; TGFβ; Proteases and proteins: MMP; GAPDH; Cytokines: MCP-1; GF; TIMP; stromal-derived factor-1; transforming growth factor β; neural cell adhesion molecule; basic fibroblast growth factor; granulocyte-colony-stimulating factor; monocyte chemotactic protein-1; nerve growth factor; tissue inhibitor of metalloproteinases; growth factors; glyceraldehydes 3-phosphate dehydrogenise; scatter factor/hepatocyte growth factor; glioblastoma; vascular endothelial growth factor; hypoxia induced factor; granulocyte-macrophage colony-stimulating factor; matrix metalloproteinase; macrophage inflammatory protein 1alpha