Serotonin Promotes Development and Regeneration of Spinal Motor Neurons in Zebrafish

• Published in: Cell reports (Cambridge) Vol. 13; no. 5; pp. 924 - 932
• Main Authors: Barreiro-Iglesias, Antón, Mysiak, Karolina S., Scott, Angela L., Reimer, Michell M., Yang (杨宇婕), Yujie, Becker, Catherina G., Becker, Thomas
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 03.11.2015; Cell Press; Elsevier
• Subjects: Animals; Interneurons - cytology; Interneurons - drug effects; Interneurons - metabolism; Motor Neurons - cytology; Motor Neurons - drug effects; Motor Neurons - metabolism; Nerve Regeneration; Neural Stem Cells - cytology; Neural Stem Cells - drug effects; Neural Stem Cells - metabolism; Receptor, Serotonin, 5-HT1A - metabolism; Serotonin - metabolism; Serotonin - pharmacology; Spinal Cord - cytology; Spinal Cord - growth & development; Spinal Cord - physiology; Zebrafish
• ISSN: 2211-1247; 2211-1247
• DOI: 10.1016/j.celrep.2015.09.050

In contrast to mammals, zebrafish regenerate spinal motor neurons. During regeneration, developmental signals are re-deployed. Here, we show that, during development, diffuse serotonin promotes spinal motor neuron generation from pMN progenitor cells, leaving interneuron numbers unchanged. Pharmacol...