CLEC-2 is required for development and maintenance of lymph nodes

• Published in: Blood Vol. 123; no. 20; pp. 3200 - 3207
• Main Authors: Bénézech, Cécile, Nayar, Saba, Finney, Brenda A., Withers, David R., Lowe, Kate, Desanti, Guillaume E., Marriott, Clare L., Watson, Steve P., Caamaño, Jorge H., Buckley, Christopher D., Barone, Francesca
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.05.2014; American Society of Hematology
• Subjects: Animals; Blood Platelets - metabolism; Cell Proliferation; Cells, Cultured; Endothelium, Lymphatic - cytology; Endothelium, Lymphatic - metabolism; Gene Deletion; Lectins, C-Type - genetics; Lectins, C-Type - metabolism; Lymph Nodes - cytology; Lymph Nodes - growth & development; Lymph Nodes - metabolism; Lymphangiogenesis; Megakaryocytes - metabolism; Mice; Mice, Inbred C57BL; Vascular Biology

The importance of CLEC-2, a natural ligand/receptor for Gp38/Podoplanin, in the formation of the lymphatic vasculature has recently been demonstrated. As the development and maintenance of lymph nodes (LNs) is dependent on the formation of the lymphatic vasculature and the differentiation of Gp38/Po...