Potent neutralization of SARS-CoV-2 variants of concern by an antibody with an uncommon genetic signature and structural mode of spike recognition - Kramer, Kevin J.; Johnson, Nicole V.; Shiakolas, Andrea R.; Suryadevara, Naveenchandra; Periasamy, Sivakumar; Raju, Nagarajan; Williams, Jazmean K.; Wrapp, Daniel; Zost, Seth J.; Walker, Lauren M.; Wall, Steven C.; Holt, Clinton M.; et al. (Cell reports (Cambridge), 2021)
Keywords: Angiotensin-Converting Enzyme 2 - chemistry; Angiotensin-Converting Enzyme 2 - immunology; Animals; Antibodies, Monoclonal - immunology; Antibodies, Neutralizing - immunology; Antibodies, Viral - immunology; antibody discovery; Antibody Formation; Cell Line; Chlorocebus aethiops; COVID-19; COVID-19 - genetics; COVID-19 - immunology; COVID-19 - virology; cryo-EM; Cryoelectron Microscopy; Delta variant; Epitope Mapping - methods; Epitopes - chemistry; Epitopes - immunology; High-Throughput Screening Assays - methods; Humans; LIBRA-seq; Male; Middle Aged; monoclonal antibodies biology; Protein Binding; Protein Interaction Domains and Motifs; Receptors, Antigen, B-Cell - chemistry; Receptors, Antigen, B-Cell - immunology; SARS-CoV-2; SARS-CoV-2 - chemistry; SARS-CoV-2 - genetics; SARS-CoV-2 - immunology; Spike Glycoprotein, Coronavirus - chemistry; Spike Glycoprotein, Coronavirus - immunology; Vero Cells; COVID-19; SARS-CoV-2; monoclonal antibodies biology; antibody discovery; Delta variant; cryo-EM; LIBRA-seq