High-performance silicon nanopore hemofiltration membranes

Silicon micromachining provides the precise control of nanoscale features that can be fundamentally enabling for miniaturized, implantable medical devices. Concerns have been raised regarding blood biocompatibility of silicon-based materials and their application to hemodialysis and hemofiltration....

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Published inJournal of membrane science Vol. 326; no. 1; pp. 58 - 63
Main Authors Fissell, William H., Dubnisheva, Anna, Eldridge, Abigail N., Fleischman, Aaron J., Zydney, Andrew L., Roy, Shuvo
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 05.01.2009
Subjects
Artificial kidney
Hemofiltration
MEMS
Nanotechnology
Silicon
MEMS
Silicon
Hemofiltration
Nanotechnology
Artificial kidney
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Summary:Silicon micromachining provides the precise control of nanoscale features that can be fundamentally enabling for miniaturized, implantable medical devices. Concerns have been raised regarding blood biocompatibility of silicon-based materials and their application to hemodialysis and hemofiltration. A high-performance ultrathin hemofiltration membrane with monodisperse slit-shaped pores was fabricated using a sacrificial oxide technique and then surface-modified with poly(ethylene glycol) (PEG). Fluid and macromolecular transport matched model predictions well. Protein adsorption, fouling, and thrombosis were significantly inhibited by the PEG. The membrane retained hydraulic permeability and molecular selectivity during a 90-h hemofiltration experiment with anticoagulated bovine whole blood. This is the first report of successful prolonged hemofiltration with a silicon nanopore membrane. The results demonstrate feasibility of renal replacement devices based on these membranes and materials.
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ISSN:0376-7388
1873-3123
DOI:10.1016/j.memsci.2008.09.039